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| __NOTOC__
| | #REDIRECT [[Colesevelam#Patient Counseling Information]] |
| {{Colesevelam}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Patient Counseling Information==
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| '''Dosing''': Patients should be advised to take WELCHOL Tablets with a meal and liquid. WELCHOL can be taken as 6 tablets once daily or 3 tablets twice daily. Patients should be advised to take WELCHOL for Oral Suspension as one 3.75 gram packet once daily or one 1.875 gram packet twice daily. To prepare, empty the entire contents of one packet into a glass or cup. Add ½ to 1 cup (4 to 8 ounces) of water, fruit juice, or diet soft drinks. Stir well and drink. WELCHOL for Oral Suspension should be taken with meals. To avoid esophageal distress, WELCHOL for Oral Suspension should not be taken in its dry form. Always mix WELCHOL for Oral Suspension with water, fruit juice, or diet soft drinks before ingesting [See Dosage and Administration(2)]
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| '''Drug interactions''': Drugs with a known interaction with colesevelam (e.g., [[cyclosporine]],[[ glimepiride]],[[ glipizide]], [[glyburide]], [[levothyroxine]], [[olmesartan medoxomil]], [[oral contraceptives]]) should be administered at least 4 hours prior to WELCHOL. In an in vivo drug interaction study, there was no significant effect on the bioavailability of [[phenytoin]]; however, due to its narrow therapeutic index and post-marketing reports consistent with potential drug-drug interactions, phenytoin should be administered at least 4 hours prior to WELCHOL. Drugs that have not been tested for interaction with colesevelam, especially those with a narrow therapeutic index, should also be administered at least 4 hours prior to WELCHOL. Alternatively the physician should monitor blood levels of the coadministered drug. Patients receiving concomitant metformin ER and colesevelam should be monitored for clinical response as is usual for the use of anti-diabetes drugs [See Drug Interactions (7)]
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| '''Gastrointestinal''': WELCHOL can cause [[constipation]]. WELCHOL is contraindicated in patients with a history of [[bowel obstruction]]. WELCHOL is not recommended in patients who may be at risk of [[bowel obstruction]], including patients with gastroparesis, other gastrointestinal motility disorders, or a history of major gastrointestinal surgery. Patients should be instructed to consume a diet that promotes bowel regularity. Patients should be instructed to promptly discontinue WELCHOL and seek medical attention if severe abdominal pain or severe constipation occurs. Because of the tablet size, WELCHOL Tablets can cause dysphagia or esophageal obstruction and should be used with caution in patients with [[dysphagia]] or swallowing disorders. To avoid esophageal distress, WELCHOL for Oral Suspension should not be taken in its dry form. Always mix WELCHOL for Oral Suspension with water, fruit juice, or diet soft drinks before ingesting [See Warnings and Precautions (5.4)]
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| '''Hypertriglyceridemia and pancreatitis''': Patients should be instructed to discontinue WELCHOL and seek prompt medical attention if the hallmark symptoms of [[acute pancreatitis]] occur (e.g., severe abdominal pain with or without nausea and vomiting). [See Warnings and Precautions (5.2)]<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = WELCHOL (COLESEVELAM HYDROCHLORIDE) TABLET, FILM COATED WELCHOL (COLESEVELAM HYDROCHLORIDE) FOR SUSPENSION [DAIICHI SANKYO, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4a06d3b2-7229-4398-baba-5d0a72f63821 | publisher = | date = | accessdate = 10 February 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| {{Lipid modifying agents}}
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| [[Category:Hepatology]]
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| [[Category:Bile acid sequestrants]]
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| [[Category:Cardiovasuclar Drugs]]
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| [[Category:Drugs]]
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