Prochlorperazine (oral): Difference between revisions

Prochlorperazine (oral)
	File:Prochlorperazine.svg
Clinical data
Pregnancy; category	C (Au, U.S.);
Routes of; administration	Oral, buccal, rectal, IM
ATC code	N05AB04 (WHO) ;
Legal status
Legal status	OTC/POM (UK);
Pharmacokinetic data
Bioavailability	not exactly known, but substantial
Protein binding	91–99%
Metabolism	Mainly hepatic (CYP2D6 and/or CYP3A4)
Elimination half-life	4-8 hours, differs with the mode of application
Excretion	Biliary, (colored) inactive metabolites in urine
Identifiers
	IUPAC name 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-; 10H-phenothiazine;
CAS Number	58-38-8;
PubChem CID	4917;
DrugBank	APRD00624;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C20H24ClN3S
Molar mass	373.943 g/mol

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VisualWikitext

Revision as of 21:02, 12 February 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]

For patient information about Prochlorperazine, click here.

Synonyms / Brand Names: ^®,

Overview

Prochlorperazine (marketed under the names Compazine, Buccastem, Stemetil, Phenotil) is a drug that belongs to the phenothiazine class of antipsychotic agent that is used for the treatment of nausea and vertigo. It is also a typical antipsychotic drug and a highly potent neuroleptic, 10 to 20 times more potent than chlorpromazine. In Pakistan, it is marketed under the name Phenotil by Unexo Labs.

Indications

It is now relatively seldom used for the treatment of psychosis and the manic phase of bipolar disorder. It has a prominent antiemetic/antivertiginoic activity and is most often used for the (short-time) treatment of nausea and vomiting and vertigo as follows:

To alleviate the symptoms of vertigo
As an antiemetic, particularly for nausea and vomiting caused by cancer treatment, radiation and in the pre- and postoperative setting
Quite recently, in the UK prochlorperazine maleate has been made available as Buccastem M in buccal form as an over-the-counter treatment for migraine. In this indication it blocks the chemoreceptor trigger zone (CTZ) in the brain, which is responsible for causing severe nausea and vomiting. Its OTC use is strictly restricted to a maximum of 2 days, because of the potentially severe side effects of prochlorperazine, which mandate supervision by a health care provider.

Formulations and pharmacokinetics

Prochlorperazine is available as an oral liquid, tablets, and suppositories, as well as in an injectable form.

Following intramuscular injection the antiemetic action is evident within 5 to 10 minutes and lasts for 3 to 4 hours. Rapid action is also noted after buccal treatment. With oral dosing the start of action is delayed but the duration somewhat longer (approximately 6 hours).

There is an inhaled form of prochlorperazine under development by Alexza Pharmaceuticals, currently in Phase II clinical trials.

Side effects

Due to the short duration of treatment it is usually well tolerated. It shares in general all side effects of chlorpromazine, but these are seen less frequently so and are less disturbing to the patient, particularly as most patients with the aforementioned conditions are hospitalized. In the treatment of nauses/emesis it might be given together with an antiparkinsonian drug to prevent extrapyramidal side effects of prochlorperazine.

Some individuals are inherently allergic to this medicine. This medicine is known to produce seizures and seizure-like symptoms in individuals who might not have had prior seizures. In such cases, contact health-care facilities for immediate attention. Long-term delays might lead to long-term effects. In extreme cases, it has been known to produce permanent damage to the lower jaw and the jaw joint due to extended seizure symptoms.

If treating psychotic conditions on a long-term basis, the high incidence of early and late (tardive dyskinesia) extrapyramidal side effects should be considered carefully. Prochlorperazine has in the long-term treatment approximately the same incidence and severity of extrapyramidal side effects as haloperidol.

FDA Package Insert

COMPAZINE (prochlorperazine) suppository Normal 0 false false false EN-US X-NONE X-NONE

==PROCHLORPERAZINE EDISYLATE injection   Normal  0          false  false  false    EN-US  X-NONE  X-NONE                                                                                                                                                                                                                                                                                                                                                            ==

       Normal  0          false  false  false    EN-US  X-NONE  X-NONE

PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet

  Normal  0          false  false  false    EN-US  X-NONE  X-NONE                                                                                                                                                                                                                                                                                                                                                              Indications and Usage

Mechanism of Action

^[1] Normal 0 false false false EN-US X-NONE X-NONE ^[2] Normal 0 false false false EN-US X-NONE X-NONE ^[1] Normal 0 false false false EN-US X-NONE X-NONE

References

Template:Antimigraine preparations

External links

Prochlorperazine medlineplus.org article
AZ-001 (Staccato(TM) prochlorperazine) Press release pertaining to phase IIb clinical trial of inhaled prochlorperazine for migraine headache

sv:Proklorperazin sex

[dailymed.nlm.nih.gov-1] 1.0 ^1.1 "COMPAZINE (PROCHLORPERAZINE) SUPPOSITORY [PBM PHARMACEUTICALS, INC]".

[2] "PROCHLORPERAZINE EDISYLATE INJECTION [BAXTER HEALTHCARE CORPORATION]".

[1]

[2]

@@ Line 45: / Line 45: @@
 ==Side effects==
 {{see|Typical antipsychotic}}
-Due to the short duration of treatment it is usually well tolerated. It shares in general all side effects of [[chlorpromazine]], but these are seen less frequently so and are less disturbing to the patient, particularly as most patients with the aforementioned conditions are hospitalized. In the treatment of nauses/emesis it might be given together with an antiparkinsonian drug to prevent [[extrapyramidal side effects]] of prochlorperazine.
+Due to the short duration of treatment it is usually well tolerated. It shares in general all side effects of [[chlorpromazine]], but these are seen less frequently so and are less disturbing to the patient, particularly as most patients with the aforementioned conditions are hospitalized. In the treatment of nauses/emesis it might be given together with an antiparkinsonian drug to prevent extrapyramidal side effects of prochlorperazine.
 Some individuals are inherently allergic to this medicine. This medicine is known to produce [[seizures]] and seizure-like symptoms in individuals who might not have had prior seizures. In such cases, contact health-care facilities for immediate attention. Long-term delays might lead to long-term effects. In extreme cases, it has been known to produce permanent damage to the lower jaw and the jaw joint due to extended seizure symptoms.
@@ Line 53: / Line 53: @@
 ==FDA Package Insert==
-==PHENADOZ (promethazine hydrochloride) suppository==
+==COMPAZINE (prochlorperazine) suppository   Normal  0          false  false  false    EN-US  X-NONE  X-NONE                                                                                                                                                                                                                                                                                                                                                            ==
-'''  [[PHENADOZ (promethazine hydrochloride) suppository indications and usage|Indications and Usage]]'''
+'''  [[COMPAZINE (prochlorperazine) suppository indications and usage|Indications and Usage]]'''
-'''| [[PHENADOZ (promethazine hydrochloride) suppository dosage and administration|Dosage and Administration]]'''
+'''| [[COMPAZINE (prochlorperazine) suppository dosage and administration|Dosage and Administration]]'''
-'''| [[PHENADOZ (promethazine hydrochloride) suppository dosage forms and strengths|Dosage Forms and Strengths]]'''
+'''| [[COMPAZINE (prochlorperazine) suppository dosage forms and strengths|Dosage Forms and Strengths]]'''
-'''| [[PHENADOZ (promethazine hydrochloride) suppository contraindications|Contraindications]]'''
+'''| [[COMPAZINE (prochlorperazine) suppository contraindications|Contraindications]]'''
-'''| [[PHENADOZ (promethazine hydrochloride) suppository warnings and precautions|Warnings and Precautions]]'''
+'''| [[COMPAZINE (prochlorperazine) suppository warnings and precautions|Warnings and Precautions]]'''
-'''| [[PHENADOZ (promethazine hydrochloride) suppository adverse reactions|Adverse Reactions]]'''
+'''| [[COMPAZINE (prochlorperazine) suppository adverse reactions|Adverse Reactions]]'''
-'''| [[PHENADOZ (promethazine hydrochloride) suppository drug interactions|Drug Interactions]]'''
+'''| [[COMPAZINE (prochlorperazine) suppository drug interactions|Drug Interactions]]'''
-'''| [[PHENADOZ (promethazine hydrochloride) suppository use in specific populations|Use in Specific Populations]]'''
+'''| [[COMPAZINE (prochlorperazine) suppository use in specific populations|Use in Specific Populations]]'''
-'''| [[PHENADOZ (promethazine hydrochloride) suppository overdosage|Overdosage]]'''
+'''| [[COMPAZINE (prochlorperazine) suppository overdosage|Overdosage]]'''
-'''| [[PHENADOZ (promethazine hydrochloride) suppository description|Description]]'''
+'''| [[COMPAZINE (prochlorperazine) suppository description|Description]]'''
-'''| [[PHENADOZ (promethazine hydrochloride) suppository clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[COMPAZINE (prochlorperazine) suppository clinical pharmacology|Clinical Pharmacology]]'''
-'''| [[PHENADOZ (promethazine hydrochloride) suppository nonclinical toxicology|Nonclinical Toxicology]]'''
+'''| [[COMPAZINE (prochlorperazine) suppository nonclinical toxicology|Nonclinical Toxicology]]'''
-'''| [[PHENADOZ (promethazine hydrochloride) suppository clinical studies|Clinical Studies]]'''
+'''| [[COMPAZINE (prochlorperazine) suppository clinical studies|Clinical Studies]]'''
-'''| [[PHENADOZ (promethazine hydrochloride) suppository how supplied storage and handling|How Supplied/Storage and Handling]]'''
+'''| [[COMPAZINE (prochlorperazine) suppository how supplied storage and handling|How Supplied/Storage and Handling]]'''
-'''| [[PHENADOZ (promethazine hydrochloride) suppository patient counseling information|Patient Counseling Information]]'''
+'''| [[COMPAZINE (prochlorperazine) suppository patient counseling information|Patient Counseling Information]]'''
-'''| [[PHENADOZ (promethazine hydrochloride) suppository labels and packages|Labels and Packages]]'''
+'''| [[COMPAZINE (prochlorperazine) suppository labels and packages|Labels and Packages]]'''
-==PHENERGAN (promethazine hydrochloride) injection==
+ ==PROCHLORPERAZINE EDISYLATE injection   Normal  0          false  false  false    EN-US  X-NONE  X-NONE                                                                                                                                                                                                                                                                                                                                                            ==
-'''  [[PHENERGAN (promethazine hydrochloride) injection indications and usage|Indications and Usage]]'''
-'''| [[PHENERGAN (promethazine hydrochloride) injection dosage and administration|Dosage and Administration]]'''
-'''| [[PHENERGAN (promethazine hydrochloride) injection dosage forms and strengths|Dosage Forms and Strengths]]'''
-'''| [[PHENERGAN (promethazine hydrochloride) injection contraindications|Contraindications]]'''
-'''| [[PHENERGAN (promethazine hydrochloride) injection warnings and precautions|Warnings and Precautions]]'''
-'''| [[PHENERGAN (promethazine hydrochloride) injection adverse reactions|Adverse Reactions]]'''
-'''| [[PHENERGAN (promethazine hydrochloride) injection drug interactions|Drug Interactions]]'''
-'''| [[PHENERGAN (promethazine hydrochloride) injection use in specific populations|Use in Specific Populations]]'''
-'''| [[PHENERGAN (promethazine hydrochloride) injection overdosage|Overdosage]]'''
-'''| [[PHENERGAN (promethazine hydrochloride) injection description|Description]]'''
-'''| [[PHENERGAN (promethazine hydrochloride) injection clinical pharmacology|Clinical Pharmacology]]'''
-'''| [[PHENERGAN (promethazine hydrochloride) injection nonclinical toxicology|Nonclinical Toxicology]]'''
-'''| [[PHENERGAN (promethazine hydrochloride) injection clinical studies|Clinical Studies]]'''
-'''| [[PHENERGAN (promethazine hydrochloride) injection how supplied storage and handling|How Supplied/Storage and Handling]]'''
-'''| [[PHENERGAN (promethazine hydrochloride) injection patient counseling information|Patient Counseling Information]]'''
-'''| [[PHENERGAN (promethazine hydrochloride) injection labels and packages|Labels and Packages]]'''
-==PROMETHAZINE HYDROCHLORIDE solution==
+'''  [[PROCHLORPERAZINE EDISYLATE injection indications and usage|Indications and Usage]]'''
+'''| [[PROCHLORPERAZINE EDISYLATE injection dosage and administration|Dosage and Administration]]'''
+'''| [[PROCHLORPERAZINE EDISYLATE injection dosage forms and strengths|Dosage Forms and Strengths]]'''
+'''| [[PROCHLORPERAZINE EDISYLATE injection contraindications|Contraindications]]'''
+'''| [[PROCHLORPERAZINE EDISYLATE injection warnings and precautions|Warnings and Precautions]]'''
+'''| [[PROCHLORPERAZINE EDISYLATE injection adverse reactions|Adverse Reactions]]'''
+'''| [[PROCHLORPERAZINE EDISYLATE injection drug interactions|Drug Interactions]]'''
+'''| [[PROCHLORPERAZINE EDISYLATE injection use in specific populations|Use in Specific Populations]]'''
+'''| [[PROCHLORPERAZINE EDISYLATE injection overdosage|Overdosage]]'''
+'''| [[PROCHLORPERAZINE EDISYLATE injection description|Description]]'''
+'''| [[PROCHLORPERAZINE EDISYLATE injection clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[PROCHLORPERAZINE EDISYLATE injection nonclinical toxicology|Nonclinical Toxicology]]'''
+'''| [[PROCHLORPERAZINE EDISYLATE injection clinical studies|Clinical Studies]]'''
+'''| [[PROCHLORPERAZINE EDISYLATE injection how supplied storage and handling|How Supplied/Storage and Handling]]'''
+'''| [[PROCHLORPERAZINE EDISYLATE injection patient counseling information|Patient Counseling Information]]'''
+'''| [[PROCHLORPERAZINE EDISYLATE injection labels and packages|Labels and Packages]]'''
+        Normal  0          false  false  false    EN-US  X-NONE  X-NONE
+==PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet==
+   Normal  0          false  false  false    EN-US  X-NONE  X-NONE                                                                                                                                                                                                                                                                                                                                                            '''  [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet indications and usage|Indications and Usage]]'''
+'''| [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet dosage and administration|Dosage and Administration]]'''
+'''| [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet dosage forms and strengths|Dosage Forms and Strengths]]'''
+'''| [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet contraindications|Contraindications]]'''
+'''| [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet warnings and precautions|Warnings and Precautions]]'''
+'''| [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet adverse reactions|Adverse Reactions]]'''
+'''| [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet drug interactions|Drug Interactions]]'''
+'''| [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet use in specific populations|Use in Specific Populations]]'''
+'''| [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet overdosage|Overdosage]]'''
+'''| [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet description|Description]]'''
+'''| [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet nonclinical toxicology|Nonclinical Toxicology]]'''
+'''| [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet clinical studies|Clinical Studies]]'''
+'''| [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet how supplied storage and handling|How Supplied/Storage and Handling]]'''
+'''| [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet patient counseling information|Patient Counseling Information]]'''
+'''| [[PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet labels and packages|Labels and Packages]]'''
-'''  [[PROMETHAZINE HYDROCHLORIDE solution indications and usage|Indications and Usage]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE solution dosage and administration|Dosage and Administration]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE solution dosage forms and strengths|Dosage Forms and Strengths]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE solution contraindications|Contraindications]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE solution warnings and precautions|Warnings and Precautions]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE solution adverse reactions|Adverse Reactions]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE solution drug interactions|Drug Interactions]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE solution use in specific populations|Use in Specific Populations]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE solution overdosage|Overdosage]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE solution description|Description]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE solution clinical pharmacology|Clinical Pharmacology]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE solution nonclinical toxicology|Nonclinical Toxicology]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE solution clinical studies|Clinical Studies]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE solution how supplied storage and handling|How Supplied/Storage and Handling]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE solution patient counseling information|Patient Counseling Information]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE solution labels and packages|Labels and Packages]]'''
-==PROMETHAZINE HYDROCHLORIDE tablet==
-'''  [[PROMETHAZINE HYDROCHLORIDE tablet indications and usage|Indications and Usage]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE tablet dosage and administration|Dosage and Administration]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE tablet dosage forms and strengths|Dosage Forms and Strengths]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE tablet contraindications|Contraindications]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE tablet warnings and precautions|Warnings and Precautions]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE tablet adverse reactions|Adverse Reactions]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE tablet drug interactions|Drug Interactions]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE tablet use in specific populations|Use in Specific Populations]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE tablet overdosage|Overdosage]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE tablet description|Description]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE tablet clinical pharmacology|Clinical Pharmacology]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE tablet nonclinical toxicology|Nonclinical Toxicology]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE tablet clinical studies|Clinical Studies]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE tablet how supplied storage and handling|How Supplied/Storage and Handling]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE tablet patient counseling information|Patient Counseling Information]]'''
-'''| [[PROMETHAZINE HYDROCHLORIDE tablet labels and packages|Labels and Packages]]'''
 ==Mechanism of Action==
- <ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = PHENADOZ (PROMETHAZINE HYDROCHLORIDE) SUPPOSITORY [PADDOCK LABORATORIES, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9aa7b3f2-4429-4a61-ad8e-876afb14cc45 | publisher =  | date =  | accessdate = }}</ref><ref>{{Cite web  | last =  | first =  | title = PHENERGAN (PROMETHAZINE HYDROCHLORIDE) INJECTION [WEST-WARD PHARMACEUTICAL CORP.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=481866da-a712-48a5-853f-8e84aacaab6d | publisher =  | date =  | accessdate = }}</ref><ref>{{Cite web  | last =  | first =  | title = PROMETHAZINE HYDROCHLORIDE SOLUTION [HI-TECH PHARMACAL CO., INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bd8d1f9a-242c-440b-a5eb-a50f64a1c1d9 | publisher =  | date =  | accessdate = }}</ref><ref>{{Cite web  | last =  | first =  | title = PROMETHAZINE HYDROCHLORIDE TABLET [AMNEAL PHARMACEUTICALS] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=05907a49-537f-4bf2-8a5f-5e905f19fece | publisher =  | date =  | accessdate = }}</ref>
+<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = COMPAZINE (PROCHLORPERAZINE) SUPPOSITORY [PBM PHARMACEUTICALS, INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9bdba30b-53b4-427a-af74-7a39b52130b2 | publisher =  | date =  | accessdate = }}</ref>   Normal  0          false  false  false    EN-US  X-NONE  X-NONE                                                                                                                                                                                                                                                                                                                                                            <ref >{{Cite web  | last =  | first =  | title = PROCHLORPERAZINE EDISYLATE INJECTION [BAXTER HEALTHCARE CORPORATION] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5e771ba7-983f-49b4-a1f2-0f335b637433 | publisher =  | date =  | accessdate = }}</ref>   Normal  0          false  false  false    EN-US  X-NONE  X-NONE                                                                                                                                                                                                                                                                                                                                                            <ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = PROCHLORPERAZINE EDISYLATE INJECTION [BAXTER HEALTHCARE CORPORATION] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5e771ba7-983f-49b4-a1f2-0f335b637433 | publisher =  | date =  | accessdate = }}</ref>   Normal  0          false  false  false    EN-US  X-NONE  X-NONE
 ==References==

v t e Antipsychotics (neuroleptics) (N05A)
Typical	Benzamides: Levosulpiride • Nemonapride • Sulpiride • Sultopride • Tiapride • Veralipride; Butyrophenones: Azaperone • Benperidol • Bromperidol • Droperidol • Fluanisone • Haloperidol • Lenperone • Moperone • Pipamperone • Spiperone • Timiperone • Trifluperidol; Diphenylbutylpiperidines: Clopimozide • Fluspirilene • Penfluridol • Pimozide; Phenothiazines: Acepromazine • Acetophenazine • Butaperazine • Carphenazine • Chloracizine • Chlorproethazine • Chlorpromazine • Cyamemazine • Dixyrazine • Fluacizine • Fluphenazine • Levomepromazine/Methotrimeprazine • Mesoridazine • Perazine • Periciazine • Perphenazine • Piperacetazine • Pipotiazine • Prochlorperazine • Promazine • Promethazine • Propiomazine • Sulforidazine • Thiethylperazine • Thiopropazate • Thioproperazine • Thioridazine • Trifluoperazine • Triflupromazine; Thioxanthenes: Chlorprothixene • Clopenthixol • Flupentixol • Thiothixene • Zuclopenthixol; Tricyclics: Amoxapine • Butaclamol • Fluotracen • Loxapine • Metitepine/Methiothepin • Octoclothiepin • Trimipramine; Others: Prothipendyl
Atypical	Benzamides: Amisulpride • Remoxipride; Butyrophenones: Cinuperone • Setoperone; Benzo(iso)oxazole piperidines: Iloperidone • Ocaperidone • Paliperidone • Risperidone; Benzo(iso)thiazole piperazines: Lurasidone • Perospirone • Revospirone • Tiospirone • Ziprasidone; Diphenylbutylpiperazines: Amperozide; Phenylpiperazines: Aripiprazole • Bifeprunox • Elopiprazole • Umespirone; Tricyclics: Asenapine • Carpipramine • Clocapramine • Clotiapine • Clozapine • Fluperlapine • Gevotroline • Metitepine/Methiothepin • Mosapramine • NDMC • Olanzapine • Piquindone • Quetiapine • Tenilapine • Zotepine; Others: Blonanserin • Cariprazine • Molindone • Pimavanserin • Roxindole • Sarizotan • Sertindole • Spiramide
Others	Azacyclonol • Cannabidiol • D-Cycloserine • Lithium • Mifepristone • Oxypertine • Reserpine • Rimcazole • Secretin • Talnetant • Tetrabenazine • Vabicaserin
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III Template:Psychology navs

Prochlorperazine (oral): Difference between revisions

Revision as of 21:02, 12 February 2014

Overview

Indications

Formulations and pharmacokinetics

Side effects

Category

FDA Package Insert

COMPAZINE (prochlorperazine) suppository Normal 0 false false false EN-US X-NONE X-NONE

PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet

Mechanism of Action

References

External links

Navigation menu

Clinical data
File:Prochlorperazine.svg
Pregnancy category	C (Au, U.S.)
Routes of administration	Oral, buccal, rectal, IM
ATC code	N05AB04 (WHO)
Legal status
Legal status	OTC/POM (UK)
Pharmacokinetic data
Bioavailability	not exactly known, but substantial
Protein binding	91–99%
Metabolism	Mainly hepatic (CYP2D6 and/or CYP3A4)
Elimination half-life	4-8 hours, differs with the mode of application
Excretion	Biliary, (colored) inactive metabolites in urine
Identifiers
IUPAC name 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]- 10H-phenothiazine
CAS Number	58-38-8
PubChem CID	4917
DrugBank	APRD00624
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₀H₂₄ClN₃S
Molar mass	373.943 g/mol

Prochlorperazine (oral): Difference between revisions

Revision as of 21:02, 12 February 2014

Overview

Indications

Formulations and pharmacokinetics

Side effects

Category

FDA Package Insert

COMPAZINE (prochlorperazine) suppository Normal 0 false false false EN-US X-NONE X-NONE

PROCHLORPERAZINE MALEATE (prochlorperazine maleate) tablet

Mechanism of Action

References

External links

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