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| __NOTOC__
| | #REDIRECT [[Quinapril#Use in Specific Populations]] |
| {{Quinapril}}
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| {{CMG}}; {{AE}} {{AM}}
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| ==Use in specific population==
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| ====Nursing Mothers====
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| Because ACCUPRIL is secreted in human milk, caution should be exercised when this drug is administered to a nursing woman.
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| ====Pediatric Use====
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| Neonates with a history of in utero exposure to ACCUPRIL
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| If [[oliguria]] or [[hypotension]] occurs, direct attention toward support of blood pressure and renal perfusion. Exchange transfusions or dialysis may be required as a means of reversing hypotension and/or substituting for disordered renal function. Removal of ACCUPRIL, which crosses the placenta, from the neonatal circulation is not significantly accelerated by these means.
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| The safety and effectiveness of ACCUPRIL in pediatric patients have not been established.
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| ====Geriatric Use====
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| Clinical studies of ACCUPRIL did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.
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| This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
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| Elderly patients exhibited increased area under the plasma concentration time curve and peak levels for quinaprilat compared to values observed in younger patients; this appeared to relate to decreased renal function rather than to age itself.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = ACCUPRIL (QUINAPRIL HYDROCHLORIDE) TABLET, FILM COATED [PARKE-DAVIS DIV OF PFIZER INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=63cf5651-d52c-4d27-9fd4-ed9cd9724dff | publisher = | date = | accessdate = }}</ref>
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| ==References==
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| {{Reflist}}
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| {{FDA}}
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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