Esmolol contraindications: Difference between revisions
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BREVIBLOC (Esmolol Hydrochloride) is contraindicated in patients with: | BREVIBLOC (Esmolol Hydrochloride) is contraindicated in patients with: | ||
* '''Severe [[sinus bradycardia]]''': May precipitate or worsen bradycardia resulting in cardiogenic shock and cardiac arrest | * '''Severe [[sinus bradycardia]]''': May precipitate or worsen [[bradycardia]] resulting in [[cardiogenic shock]] and [[cardiac arrest]] | ||
* '''[[Heart block]]''' greater than first degree: Second- or third-degree [[atrioventricular block]] may precipitate or worsen [[bradycardia]] resulting in cardiogenic shock | * '''[[Heart block]]''' greater than first degree: Second- or third-degree [[atrioventricular block]] may precipitate or worsen [[bradycardia]] resulting in [[cardiogenic shock]] | ||
* '''[[ | * '''[[Cardiac arrest]]''' | ||
* '''[[Sick sinus syndrome]]''': May precipitate or worsen bradycardia resulting in [[cardiogenic shock]] and [[cardiac arrest]] | * '''[[Sick sinus syndrome]]''': May precipitate or worsen [[bradycardia]] resulting in [[cardiogenic shock]] and [[cardiac arrest]] | ||
* '''Decompensated [[heart failure]]''': May worsen [[heart failure]] | * '''Decompensated [[heart failure]]''': May worsen [[heart failure]] | ||
* '''[[Cardiogenic shock]]''': May precipitate further cardiovascular collapse and cause [[cardiac arrest]] | * '''[[Cardiogenic shock]]''': May precipitate further cardiovascular collapse and cause [[cardiac arrest]] | ||
* '''IV administration of cardiodepressant''' [[calcium-channel antagonists]] (e.g., [[verapamil]]) and BREVIBLOC in close proximity (i.e., while cardiac effects from the other are still present); fatal cardiac arrests have occurred in patients receiving BREVIBLOC and intravenous verapamil | * '''IV administration of cardiodepressant''' [[calcium-channel antagonists]] (e.g., [[verapamil]]) and BREVIBLOC in close proximity (i.e., while cardiac effects from the other are still present); fatal cardiac arrests have occurred in patients receiving BREVIBLOC and intravenous verapamil | ||
* '''[[Pulmonary hypertension]]''': May precipitate cardiorespiratory compromise. | * '''[[Pulmonary hypertension]]''': May precipitate cardiorespiratory compromise. | ||
* '''[[Hypersensitivity reactions]]''', including [[anaphylaxis]], to esmolol or any of the inactive ingredients of the product ([[cross-sensitivity]] between beta | * '''[[Hypersensitivity reactions]]''', including [[anaphylaxis]], to esmolol or any of the inactive ingredients of the product ([[cross-sensitivity]] between [[beta blocker]]s is possible).<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = BREVIBLOC (ESMOLOL HYDROCHLORIDE) INJECTION [BAXTER HEALTHCARE CORPORATION] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=595cc3d5-1306-4828-aefa-5595219ffd62 | publisher = | date = | accessdate = }}</ref> | ||
==References== | ==References== | ||
Revision as of 22:48, 20 February 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]
Contraindications
BREVIBLOC (Esmolol Hydrochloride) is contraindicated in patients with:
- Severe sinus bradycardia: May precipitate or worsen bradycardia resulting in cardiogenic shock and cardiac arrest
- Heart block greater than first degree: Second- or third-degree atrioventricular block may precipitate or worsen bradycardia resulting in cardiogenic shock
- Cardiac arrest
- Sick sinus syndrome: May precipitate or worsen bradycardia resulting in cardiogenic shock and cardiac arrest
- Decompensated heart failure: May worsen heart failure
- Cardiogenic shock: May precipitate further cardiovascular collapse and cause cardiac arrest
- IV administration of cardiodepressant calcium-channel antagonists (e.g., verapamil) and BREVIBLOC in close proximity (i.e., while cardiac effects from the other are still present); fatal cardiac arrests have occurred in patients receiving BREVIBLOC and intravenous verapamil
- Pulmonary hypertension: May precipitate cardiorespiratory compromise.
- Hypersensitivity reactions, including anaphylaxis, to esmolol or any of the inactive ingredients of the product (cross-sensitivity between beta blockers is possible).[1]
References
Adapted from the FDA Package Insert.