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| __NOTOC__
| | #REDIRECT [[Losartan#Drug Interactions]] |
| {{Losartan}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Drug Interactions==
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| Losartan, administered for 12 days, did not affect the pharmacokinetics or pharmacodynamics of a single dose of [[warfarin]]. Losartan did not affect the pharmacokinetics of oral or intravenous [[digoxin]]. There is no pharmacokinetic interaction between losartan and [[hydrochlorothiazide]]. Coadministration of losartan and [[cimetidine]] led to an increase of about 18% in AUC of losartan but did not affect the pharmacokinetics of its active metabolite. Coadministration of losartan and [[phenobarbital]] led to a reduction of about 20% in the AUC of losartan and that of its active metabolite. A somewhat greater interaction (approximately 40% reduction in the AUC of active metabolite and approximately 30% reduction in the AUC of losartan) has been reported with [[rifampin]]. [[Fluconazole]], an inhibitor of cytochrome P450 2C9, decreased the AUC of the active metabolite by approximately 40%, but increased the AUC of losartan by approximately 70% following multiple doses. Conversion of losartan to its active metabolite after intravenous administration is not affected by [[ketoconazole]], an inhibitor of P450 3A4. The AUC of active metabolite following oral losartan was not affected by [[erythromycin]], another inhibitor of P450 3A4, but the AUC of losartan was increased by 30%.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = COZAAR (LOSARTAN POTASSIUM) TABLET, FILM COATED [MERCK SHARP & DOHME CORP.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5ac32c20-169d-475a-fc8a-934f758d6ab0 | publisher = | date = | accessdate = 20 February 2014 }}</ref>
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| ==References==
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| {{Reflist}}
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| {{Angiotensin II receptor antagonists}}
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| [[Category:Alcohols]]
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| [[Category:Angiotensin II receptor antagonists]]
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| [[Category:Imidazoles]]
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| [[Category:Organochlorides]]
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| [[Category:Tetrazoles]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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