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==Historical Perspective==
==Historical Perspective==
It has long been assumed
Recent evidence suggests that the different thymic epithelial populations all develop from a common thymic epithelial stem cell of endodermal origin. Not as assumed before that thymic epithelial cells originate from both the ectodermal and endodermal germ cell layers. This concept does not exclude the occurrence of more differentiated “committed stem cells” with medullary, cortical or other phenotypes. The different types of thymomas develop from the thymic epithelium.<ref>{{Cite web  | last =  | first =  | title = http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/BB10.pdf | url = http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/BB10.pdf | publisher =  | date =  | accessdate = }}</ref>
that thymic epithelial cells originate from
both the ectodermal and endodermal
germ cell layers. However, a growing
body of evidence suggests that the
diverse thymic epithelial populations all
develop from a common thymic epithelial
stem cell of endodermal origin {181, 684}.
This concept does not exclude the occurrence
of more differentiated “committed
stem cells” with medullary, cortical or
other phenotypes {1671}. Tumours that
we know as thymomas derive from thymic
epithelium. In spite of morphological and
immunological evidence for tumour differentiation
towards a medullary or cortical
epithelial phenotype, available data do
not allow to unequivocally assign thymic
tumours to defined functional and
anatomical compartments of the normal
thymus {1691}.
<ref>{{Cite web  | last =  | first =  | title = http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/BB10.pdf | url = http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/BB10.pdf | publisher =  | date =  | accessdate = }}</ref>
 
 


==References==
==References==

Revision as of 20:30, 21 February 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Amr Marawan, M.D. [2]

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Historical Perspective

Recent evidence suggests that the different thymic epithelial populations all develop from a common thymic epithelial stem cell of endodermal origin. Not as assumed before that thymic epithelial cells originate from both the ectodermal and endodermal germ cell layers. This concept does not exclude the occurrence of more differentiated “committed stem cells” with medullary, cortical or other phenotypes. The different types of thymomas develop from the thymic epithelium.[1]

References

  1. "http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/BB10.pdf" (PDF). External link in |title= (help)


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