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| __NOTOC__
| | #REDIRECT [[Olmesartan#Drug Interactions]] |
| {{Olmesartan}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Drug Interactions==
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| No significant drug interactions were reported in studies in which Benicar was co-administered with [[digoxin]] or [[warfarin]] in healthy volunteers.
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| The bioavailability of olmesartan was not significantly altered by the co-administration of antacids [Al(OH)3/Mg(OH)2].
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| Olmesartan medoxomil is not metabolized by the cytochrome P450 system and has no effects on P450 enzymes; thus, interactions with drugs that inhibit, induce, or are metabolized by those enzymes are not expected.
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| ===Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors)===
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| In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, co-administration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists, including olmesartan medoxomil, may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Monitor renal function periodically in patients receiving olmesartan medoxomil and [[NSAID]] therapy.
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| The [[antihypertensive effect]] of angiotensin II receptor antagonists, including olmesartan medoxomil may be attenuated by [[NSAIDs]] including selective COX-2 inhibitors.
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| ===Dual Blockade of the Renin-Angiotensin System (RAS)===
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| Dual blockade of the RAS with [[angiotensin]] receptor blockers, ACE inhibitors, or [[aliskiren ]]is associated with increased risks of [[hypotension]], [[hyperkalemia]], and changes in renal function (including [[acute renal failure]]) compared to monotherapy. Closely monitor blood pressure, renal function and electrolytes in patients on Benicar and other agents that affect the RAS.
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| Do not co-administer [[aliskiren ]]with Benicar in patients with diabetes [see Contraindications (4)]. Avoid use of [[aliskiren ]]with Benicar in patients with renal impairment (GFR <60 ml/min).
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| ===Colesevelam hydrochloride===
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| Concurrent administration of bile acid sequestering agent colesevelam hydrochloride reduces the systemic exposure and peak plasma concentration of olmesartan. Administration of olmesartan at least 4 hours prior to colesevelam hydrochloride decreased the drug interaction effect. Consider administering olmesartan at least 4 hours before the colesevelam hydrochloride dose [see Clinical Pharmacology (12.3)].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = BENICAR (OLMESARTAN MEDOXOMIL) TABLET, FILM COATED [DAIICHI SANKYO, INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=33770d80-754f-11de-8dba-0002a5d5c51b | publisher = | date = | accessdate = 21 February 2014 }}</ref>
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| ==References==
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| {{Reflist}}
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| {{Angiotensin II receptor antagonists}}
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| [[Category:Angiotensin II receptor antagonists]]
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| [[Category:Imidazoles]]
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| [[Category:Tetrazoles]]
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| [[Category:Carboxylate esters]]
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| [[Category:Alcohols]]
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| [[Category:Biphenyls]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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