Acetazolamide drug interactions: Difference between revisions
Created page with "__NOTOC__ {{Acetazolamide}} {{CMG}}; {{AE}} {{SS}} ==Drug Interactions== ===Aspirin - See WARNINGS=== DIAMOX modifies phenytoin metabolism with increased serum levels of ph..." |
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===Aspirin - See WARNINGS=== | ===Aspirin - See WARNINGS=== | ||
DIAMOX modifies phenytoin metabolism with increased serum levels of phenytoin. This may increase or enhance the occurrence of osteomalacia in some patients receiving chronic phenytoin therapy. Caution is advised in patients receiving chronic concomitant therapy. By decreasing the gastrointestinal absorption of primidone, DIAMOX may decrease serum concentrations of primidone and its metabolites, with a consequent possible decrease in anticonvulsant effect. Caution is advised when beginning, discontinuing, or changing the dose of DIAMOX in patients receiving primidone. | DIAMOX modifies phenytoin metabolism with increased serum levels of [[phenytoin]]. This may increase or enhance the occurrence of [[osteomalacia]] in some patients receiving chronic phenytoin therapy. Caution is advised in patients receiving chronic concomitant therapy. By decreasing the gastrointestinal absorption of primidone, DIAMOX may decrease serum concentrations of [[primidone]] and its metabolites, with a consequent possible decrease in anticonvulsant effect. Caution is advised when beginning, discontinuing, or changing the dose of DIAMOX in patients receiving [[primidone]]. | ||
Because of possible additive effects with other carbonic anhydrase inhibitors, concomitant use is not advisable. | Because of possible additive effects with other carbonic anhydrase inhibitors, concomitant use is not advisable. | ||
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Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of their effect. | Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of their effect. | ||
Acetazolamide reduces urinary excretion of quinidine and may enhance its effect. | Acetazolamide reduces urinary excretion of [[quinidine]] and may enhance its effect. | ||
Acetazolamide may prevent the urinary antiseptic effect of methenamine. Acetazolamide increases lithium excretion and the lithium may be decreased. | Acetazolamide may prevent the urinary antiseptic effect of [[methenamine]]. Acetazolamide increases [[lithium]] excretion and the [[lithium]] may be decreased. | ||
Acetazolamide and sodium bicarbonate used concurrently increase the risk of renal calculus formation. | Acetazolamide and sodium bicarbonate used concurrently increase the risk of renal calculus formation. | ||
Acetazolamide may elevate cyclosporine levels. | Acetazolamide may elevate [[cyclosporine]] levels. | ||
===Drug/laboratory test interactions=== | ===Drug/laboratory test interactions=== | ||
Sulfonamides may give false negative or decreased values for urinary phenolsulfonphthalein and phenol red elimination values for urinary protein, serum non-protein, and serum uric acid. Acetazolamide may produce an increased level of crystals in the urine. | [[Sulfonamides]] may give false negative or decreased values for urinary phenolsulfonphthalein and phenol red elimination values for urinary protein, serum non-protein, and serum uric acid. Acetazolamide may produce an increased level of crystals in the urine. | ||
Acetazolamide interferes with the HPLC method of assay for theophylline. Interference with the theophylline assay by acetazolamide depends on the solvent used in the extraction; acetazolamide may not interfere with other assay methods for theophylline.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = DIAMOX SEQUELS (ACETAZOLAMIDE) CAPSULE, EXTENDED RELEASE [DURAMED PHARMACEUTICALS, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=74e47451-2bc8-496e-88ad-c10002ee8e22 | publisher = | date = | accessdate = 25 February 2014 }}</ref> | Acetazolamide interferes with the HPLC method of assay for [[theophylline]]. Interference with the [[theophylline]] assay by [[acetazolamide]] depends on the solvent used in the extraction; acetazolamide may not interfere with other assay methods for [[theophylline]].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = DIAMOX SEQUELS (ACETAZOLAMIDE) CAPSULE, EXTENDED RELEASE [DURAMED PHARMACEUTICALS, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=74e47451-2bc8-496e-88ad-c10002ee8e22 | publisher = | date = | accessdate = 25 February 2014 }}</ref> | ||
==References== | ==References== | ||
Revision as of 02:36, 26 February 2014
| Acetazolamide |
|---|
| DIAMOX SEQUELS® FDA Package Insert |
| Indications and Usage |
| Dosage and Administration |
| Contraindications |
| Warnings and Precautions |
| Adverse Reactions |
| Drug Interactions |
| Use in Specific Populations |
| Overdosage |
| Description |
| Clinical Pharmacology |
| Nonclinical Toxicology |
| How Supplied/Storage and Handling |
| Labels and Packages |
| Clinical Trials on Acetazolamide |
| ClinicalTrials.gov |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]
Drug Interactions
Aspirin - See WARNINGS
DIAMOX modifies phenytoin metabolism with increased serum levels of phenytoin. This may increase or enhance the occurrence of osteomalacia in some patients receiving chronic phenytoin therapy. Caution is advised in patients receiving chronic concomitant therapy. By decreasing the gastrointestinal absorption of primidone, DIAMOX may decrease serum concentrations of primidone and its metabolites, with a consequent possible decrease in anticonvulsant effect. Caution is advised when beginning, discontinuing, or changing the dose of DIAMOX in patients receiving primidone.
Because of possible additive effects with other carbonic anhydrase inhibitors, concomitant use is not advisable.
Acetazolamide may increase the effects of other folic acid antagonists.
Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of their effect.
Acetazolamide reduces urinary excretion of quinidine and may enhance its effect.
Acetazolamide may prevent the urinary antiseptic effect of methenamine. Acetazolamide increases lithium excretion and the lithium may be decreased.
Acetazolamide and sodium bicarbonate used concurrently increase the risk of renal calculus formation.
Acetazolamide may elevate cyclosporine levels.
Drug/laboratory test interactions
Sulfonamides may give false negative or decreased values for urinary phenolsulfonphthalein and phenol red elimination values for urinary protein, serum non-protein, and serum uric acid. Acetazolamide may produce an increased level of crystals in the urine.
Acetazolamide interferes with the HPLC method of assay for theophylline. Interference with the theophylline assay by acetazolamide depends on the solvent used in the extraction; acetazolamide may not interfere with other assay methods for theophylline.[1]
References
- ↑ "DIAMOX SEQUELS (ACETAZOLAMIDE) CAPSULE, EXTENDED RELEASE [DURAMED PHARMACEUTICALS, INC.]". Retrieved 25 February 2014.
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