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| __NOTOC__
| | #REDIRECT [[Amiloride#Drug Interactions]] |
| {{Amiloride}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Drug Interactions==
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| When amiloride HCl is administered concomitantly with an angiotensin-converting enzyme inhibitor, an [[angiotensin II receptor antagonist]], [[cyclosporine]] or [[tacrolimus]], the risk of [[hyperkalemia]]may be increased. Therefore, if concomitant use of these agents is indicated because of demonstrated [[hypokalemia]], they should be used with caution and with frequent monitoring of serum potassium. (See WARNINGS.)
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| Lithium generally should not be given with [[diuretics ]]because they reduce its renal clearance and add a high risk of [[lithium]] toxicity. Read circulars for [[lithium]] preparations before use of such concomitant therapy.
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| In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the [[diuretic]], natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide [[diuretics]]. Therefore, when MIDAMOR and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the [[diuretic]] is obtained. Since indomethacin and potassium-sparing [[diuretics]], including MIDAMOR, may each be associated with increased serum potassium levels, the potential effects on potassium kinetics and renal function should be considered when these agents are administered concurrently.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = MIDAMOR (AMILORIDE HYDROCHLORIDE) TABLET [PADDOCK LABORATORIES, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f4cde6e4-12cb-4e30-920f-5b94576b4863 | publisher = | date = | accessdate = 26 February 2014 }}</ref>
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| ==References==
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| {{reflist|2}}
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| {{Sodium channel blockers}}
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| {{Diuretics}}
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| [[Category:Potassium-sparing diuretics]]
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| [[Category:Aminopyrazines]]
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| [[Category:Guanidines]]
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| [[Category:World Health Organization essential medicines]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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