Template:Cystitis medical therapy

Empiric Therapy for Acute Cystitis

Acute Bacterial Uncomplicated Cystitis Preferred Regimen ▸ Nitrofurantoin 100 mg PO q12h × 5 days OR ▸ TMP 100 mg PO q12h ×3 days OR ▸ Fosfomycin 3 gm PO single dose OR If resistence<20% or if used for UTI >3 months ▸ TMP-SMX ‡ 1 DS tab PO q12h × 3 days OR Not FDA approved but used in some European countries ▸ Pivmecillinam 400 mg PO q12h 3-7 days Alternative Regimen ▸ Fluoroquinolones for 3 days ▸Ofloxacin 200–400 mg PO bid OR ▸Ciprofloxacin 250 mg bid PO or Cipro XR 500 mg q24h OR ▸Levofloxacin 250–750 mg PO q24 OR ▸ β-lactam agents for 3-7 days ▸Amoxicillin-clavulanate 500/125 mg PO q8h or 875/125 mg PO q8h OR ▸Cefdinir 300 mg PO q12h or 600 mg PO q24 OR Cefaclor 250-500 mg PO q8h OR ▸Cefpodoxime proxetil 100-200 mg PO q12h OR Cephalexin250-500 mg PO q6h not studied well but effective.

Complicated/Catheter Associated Cystitis Preferred Regimen Mild Infection ▸ Levofloxacin 750 mg PO q24 × 5 days Delayed Response ▸ Levofloxacin 750 mg PO q24 × 10-14 days After Catheter Removal ▸ Levofloxacin 750 mg PO q24 × 3 days Acute Cystitis in Pregnancy Preferred Regimen ▸Nitrofurantoin 100 mg PO q12h × 3-5 days OR ▸ Fosfomycin 3 g PO single dose OR ▸Amoxicillin-clavulanate 500/125 mg PO q12h × 3-5 days OR ▸ Amoxicillin 500 mg PO q12h × 3-5 days OR ▸Cephalexin 500 mg PO q12h × 3-5 days OR ▸ TMP-SMX DS 1 tab PO q12h × 3-5 days avoid in first trimester(TMP) and third trimester (SMX).