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| __NOTOC__
| | #REDIRECT [[Fenoldopam#Use in Specific Populations]] |
| {{Fenoldopam}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Use in Specific Populations==
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| '''Pregnancy: Pregnancy Category B'''. Oral reproduction studies have been performed in rats and rabbits at doses of 12.5 to 200 mg/kg/day and 6.25 to 25 mg/kg/day, respectively. Studies have revealed maternal toxicity at the highest doses tested but no evidence of impaired fertility or harm to the fetus due to fenoldopam. However, there are no adequate and well-controlled studies in pregnant women. Since animal reproduction studies are not always predictive of human response, fenoldopam should be used in pregnancy only if clearly needed.
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| '''Nursing Mothers''': Fenoldopam is excreted in milk in rats. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when fenoldopam is administered to a nursing woman.
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| '''Pediatric Use''': Anti-hypertensive effects of fenoldopam have been studied in pediatric patients age < 1 month (at least 2 kg or full term) to 12 years old requiring blood pressure reduction
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| (see Pharmacodynamics and Clinical Studies, Pediatric Patients).
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| Clinical studies of fenoldopam did not include subjects ages 12 to 16 years of age to determine if they respond differently from younger subjects or adults. The pharmacokinetics of fenoldopam are independent of age when corrected for body weight. Dose selection for patients 12 to 16 years of age should consider the patient's clinical condition and concomitant drug therapy.
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| '''Geriatric Use''': Clinical studies of fenoldopam did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = CORLOPAM (FENOLDOPAM MESYLATE) INJECTION, SOLUTION [HOSPIRA, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=df4cd207-c3b8-4008-5290-02f296c2b4a6 | publisher = | date = | accessdate = 26 February 2014 }}</ref>
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| == References ==
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| {{Reflist|2}}
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| {{Sympatholytic antihypertensives}}
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| {{Dopaminergics}}
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| [[Category:Benzazepines]]
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| [[Category:D1-receptor agonists]]
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| [[Category:Phenols]]
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| [[Category:Organochlorides]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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