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| __NOTOC__
| | #REDIRECT [[Felodipine#Overdosage]] |
| {{Felodipine}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Overdosage==
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| Oral doses of 240 mg/kg and 264 mg/kg in male and female mice, respectively, and 2390 mg/kg and 2250 mg/kg in male and female rats, respectively, caused significant lethality.
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| In a suicide attempt, one patient took 150 mg felodipine together with 15 tablets each of [[atenolol]] and [[spironolactone]] and 20 tablets of nitrazepam. The patient's blood pressure and heart rate were normal on admission to hospital; he subsequently recovered without significant sequelae.
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| Overdosage might be expected to cause excessive peripheral vasodilation with marked [[hypotension]] and possibly [[bradycardia]]. | |
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| If severe [[hypotension]]occurs, symptomatic treatment should be instituted. The patient should be placed supine with the legs elevated. The administration of intravenous fluids may be useful to treat [[hypotension]]due to overdosage with [[calcium antagonists]]. In case of accompanying [[bradycardia]], [[atropine]] (0.5−1 mg) should be administered intravenously. Sympathomimetic drugs may also be given if the physician feels they are warranted.
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| It has not been established whether felodipine can be removed from the circulation by [[hemodialysis]].
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| To obtain up-to-date information about the treatment of overdose, consult your Regional Poison-Control Center. Telephone numbers of certified poison-control centers are listed in the Physicians’ Desk Reference (PDR). In managing overdose, consider the possibilities of multiple-drug overdoses, drug-drug interactions, and unusual drug kinetics in your patient.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = PLENDIL (FELODIPINE) TABLET, EXTENDED RELEASE [ASTRAZENECA LP] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2aad9cdf-6431-4661-5cb4-f69e735f47e4 | publisher = | date = | accessdate = 28 February 2014 }}</ref>
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| ==References ==
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| {{Reflist|2}}
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| {{Calcium channel blockers}}
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| [[Category:Calcium channel blockers]]
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| [[Category:Dihydropyridines]]
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| [[Category:Carboxylate esters]]
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| [[Category:Organochlorides]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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