Reserpine use in specific populations: Difference between revisions
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==Use In Specific Populations== | |||
===Pregnancy Category C=== | |||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = RESERPINE TABLET [EON LABS, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3a4d74d7-2e63-4789-b50e-af17ced92462 | publisher = | date = | accessdate = 7 March 2014 }}</ref> | Reserpine administered parenterally has been shown to be teratogenic in rats at doses up to 2 mg/kg and to have an embryocidal effect in guinea pigs given dosages of 0.5 mg daily. | ||
There are no adequate and well-controlled studies of reserpine in pregnant women. Reserpine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. | |||
====Nonteratogenic Effects==== | |||
Reserpine crosses the placental barrier, and increased respiratory tract secretions, [[nasal congestion]], [[cyanosis]], and [[anorexia ]]may occur in [[neonates ]]of reserpine-treated mothers. | |||
===Nursing Mothers=== | |||
Reserpine is excreted in maternal breast milk, and increased respiratory tract secretions, nasal congestion, [[cyanosis]], and [[anorexia ]]may occur in breast-fed infants. Because of the potential for adverse reactions in nursing infants and the potential for tumorigenicity shown for reserpine in animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. | |||
===Pediatric Use=== | |||
Safety and effectiveness in children have not been established by means of controlled clinical trials, although there is experience with the use of reserpine in children (see [[Reserpine dosage and administration|DOSAGE AND ADMINISTRATION]].) Because of adverse effects such as emotional depression and lability, sedation, and stuffy nose, reserpine is not usually recommended as a step-2 drug in the treatment of hypertension in children.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = RESERPINE TABLET [EON LABS, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3a4d74d7-2e63-4789-b50e-af17ced92462 | publisher = | date = | accessdate = 7 March 2014 }}</ref> | |||
Revision as of 17:54, 12 March 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdurahman Khalil, M.D. [2]
Use In Specific Populations
Pregnancy Category C
Reserpine administered parenterally has been shown to be teratogenic in rats at doses up to 2 mg/kg and to have an embryocidal effect in guinea pigs given dosages of 0.5 mg daily.
There are no adequate and well-controlled studies of reserpine in pregnant women. Reserpine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Nonteratogenic Effects
Reserpine crosses the placental barrier, and increased respiratory tract secretions, nasal congestion, cyanosis, and anorexia may occur in neonates of reserpine-treated mothers.
Nursing Mothers
Reserpine is excreted in maternal breast milk, and increased respiratory tract secretions, nasal congestion, cyanosis, and anorexia may occur in breast-fed infants. Because of the potential for adverse reactions in nursing infants and the potential for tumorigenicity shown for reserpine in animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Pediatric Use
Safety and effectiveness in children have not been established by means of controlled clinical trials, although there is experience with the use of reserpine in children (see DOSAGE AND ADMINISTRATION.) Because of adverse effects such as emotional depression and lability, sedation, and stuffy nose, reserpine is not usually recommended as a step-2 drug in the treatment of hypertension in children.[1]
References
- ↑ "RESERPINE TABLET [EON LABS, INC.]". Retrieved 7 March 2014.