Mecamylamine precautions: Difference between revisions
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==PRECAUTIONS== | |||
===General=== | |||
The patient's condition should be evaluated carefully, particularly as to renal and cardiovascular function. When renal, cerebral, or coronary blood flow is deficient, any additional impairment, which might result from added [[hypotension]], must be avoided. The use of Mecamylamine HCl in patients with marked cerebral and coronary [[arteriosclerosis ]]or after a recent cerebral accident requires caution. | |||
The action of Mecamylamine HCl may be potentiated by excessive heat, fever, infection, hemorrhage, pregnancy, [[anesthesia]], surgery, vigorous exercise, other antihypertensive drugs, [[alcohol]], and salt depletion as a result of diminished intake or increased excretion due to diarrhea, vomiting, excessive sweating, or diuretics. | |||
During therapy with Mecamylamine HCl, sodium intake should not be restricted but, if necessary, the dosage of the ganglion blocker must be adjusted. | |||
Since urinary retention may occur in patients on ganglion blockers, caution is required in patients with [[prostatic hypertrophy]], bladder neck obstruction, and [[urethral stricture]]. | |||
Frequent loose bowel movements with abdominal distention and decreased [[borborygmi ]]may be the first signs of paralytic [[ileus]]. If these are present, Mecamylamine HCl should be discontinued immediately and remedial steps taken. | |||
===Information for Patients=== | |||
Mecamylamine HCl may cause [[dizziness]], [[lightheadedness]], or fainting, especially when rising from a lying or sitting position. This effect may be increased by [[alcoholic beverages]], exercise, or during hot weather. Getting up slowly may help alleviate such a reaction.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = VECAMYL (MECAMYLAMINE HYDROCHLORIDE) TABLET [MANCHESTER PHARMACEUTICALS] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c6822ce4-e741-4366-b72a-5f5146354f97 | publisher = | date = | accessdate = 10 March 2014 }}</ref> | |||
==References== | ==References== | ||
Revision as of 14:44, 10 March 2014
| Mecamylamine |
|---|
| Mecamylamine tablet®, Vecamyl® FDA Package Insert |
| Indications and Usage |
| Dosage and Administration |
| Contraindications |
| Warnings |
| Precautions |
| Adverse Reactions |
| Drug Interactions |
| Use in Specific Populations |
| Overdosage |
| Description |
| Clinical Pharmacology |
| Nonclinical Toxicology |
| How Supplied/Storage and Handling |
| Patient Counseling Information |
| Labels and Packages |
| Clinical Trials on Mecamylamine |
| ClinicalTrials.gov |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdurahman Khalil, M.D. [2]
PRECAUTIONS
General
The patient's condition should be evaluated carefully, particularly as to renal and cardiovascular function. When renal, cerebral, or coronary blood flow is deficient, any additional impairment, which might result from added hypotension, must be avoided. The use of Mecamylamine HCl in patients with marked cerebral and coronary arteriosclerosis or after a recent cerebral accident requires caution.
The action of Mecamylamine HCl may be potentiated by excessive heat, fever, infection, hemorrhage, pregnancy, anesthesia, surgery, vigorous exercise, other antihypertensive drugs, alcohol, and salt depletion as a result of diminished intake or increased excretion due to diarrhea, vomiting, excessive sweating, or diuretics.
During therapy with Mecamylamine HCl, sodium intake should not be restricted but, if necessary, the dosage of the ganglion blocker must be adjusted.
Since urinary retention may occur in patients on ganglion blockers, caution is required in patients with prostatic hypertrophy, bladder neck obstruction, and urethral stricture.
Frequent loose bowel movements with abdominal distention and decreased borborygmi may be the first signs of paralytic ileus. If these are present, Mecamylamine HCl should be discontinued immediately and remedial steps taken.
Information for Patients
Mecamylamine HCl may cause dizziness, lightheadedness, or fainting, especially when rising from a lying or sitting position. This effect may be increased by alcoholic beverages, exercise, or during hot weather. Getting up slowly may help alleviate such a reaction.[1]
References
- ↑ "VECAMYL (MECAMYLAMINE HYDROCHLORIDE) TABLET [MANCHESTER PHARMACEUTICALS]". Retrieved 10 March 2014.