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__NOTOC__
{{DrugProjectFormSinglePage
{{Mexiletine}}
|authorTag=


{{CMG}}; {{AE}} {{SS}}; {{AZ}}
Gerald Chi


'''''For patient information about Mexiletine, click [[Mexiletine (patient information)|here]].'''''
<!--Overview-->


{{SB}} MEXILETINE HYDROCHLORIDE<sup>®</sup>
|genericName=


==Overview==


'''Mexiletine''' ([[International Nonproprietary Name|INN]], sold under the trade name '''Mexitil®''') belongs to the [[Class IB anti-arrhythmic]] group of medicines. It is used to treat [[arrhythmia]]s within the [[heart]] - or seriously irregular heartbeats. It slows nerve impulses in the heart and makes the heart tissue less sensitive. Dizziness, heartburn, nausea, nervousness, trembling, unsteadiness are common side effects. It is available in injection and capsule form.


Class IB [[antiarrhythmic]]s decrease action potential duration by shortening the repolarization phase.  This is achieved by blocking sodium channels[http://www.rxlist.com/cgi/generic/mexiletine_cp.htm].
|aOrAn=


Mexiletine may also be of use in patients experiencing refractory pain. (Sweetman, 2002) and is also effective for treating muscle stiffness resulting from [[myotonia congenita]] ([[Thomsen disease]])
a


==Category==
|drugClass=


Sodium channel blockers; Phenol ethers; Cardiovascular Drugs


==FDA Package Insert==


====MEXILETINE HYDROCHLORIDE capsule====
|indication=


'''  [[Mexiletine indications and usage|Indications and Usage]]'''
'''| [[Mexiletine dosage and administration|Dosage and Administration]]'''
'''| [[Mexiletine contraindications|Contraindications]]'''
'''| [[Mexiletine warnings and precautions|Warnings and Precautions]]'''
'''| [[Mexiletine adverse reactions|Adverse Reactions]]'''
'''| [[Mexiletine drug interactions|Drug Interactions]]'''
'''| [[Mexiletine use in specific populations|Use in Specific Populations]]'''
'''| [[Mexiletine overdosage|Overdosage]]'''
'''| [[Mexiletine description|Description]]'''
'''| [[Mexiletine clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Mexiletine nonclinical toxicology|Nonclinical Toxicology]]'''
'''| [[Mexiletine clinical studies|Clinical Studies]]'''
'''| [[Mexiletine how supplied storage and handling|How Supplied/Storage and Handling]]'''
'''| [[Mexiletine labels and packages|Labels and Packages]]'''


{|
|[[File:Mexiletine02.jpg|thumb|800px]]
|}


==Mechanism of Action==
|hasBlackBoxWarning=


Mexiletine hydrochloride is a local anesthetic, antiarrhythmic agent, structurally similar to lidocaine, but orally active. In animal studies, mexiletine has been shown to be effective in the suppression of induced ventricular arrhythmias, including those induced by glycoside toxicity and coronary artery ligation. Mexiletine, like lidocaine, inhibits the inward sodium current, thus reducing the rate of rise of the action potential, Phase 0. Mexiletine decreased the effective refractory period (ERP) in Purkinje fibers. The decrease in ERP was of lesser magnitude than the decrease in action potential duration (APD), with a resulting increase in the ERP/APD ratio.
Yes


==References==
|adverseReactions=


{{Reflist|2}}




{{Antiarrhythmic agents}}
<!--Black Box Warning-->
 
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<!--Category-->


[[Category:Sodium channel blockers]]
[[Category:Phenol ethers]]
[[Category:Cardiovascular Drugs]]
[[Category:Cardiovascular Drugs]]
[[Category:Drugs]]
[[Category:Drug]]

Revision as of 23:40, 12 July 2014

Mexiletine
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gerald Chi

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Black Box Warning

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Mexiletine is a that is FDA approved for the {{{indicationType}}} of . There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Mexiletine in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Mexiletine in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Mexiletine in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Mexiletine in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Mexiletine in pediatric patients.

Contraindications

  • Condition1

Warnings

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Mexiletine in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Mexiletine in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Mexiletine in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Mexiletine during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Mexiletine with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Mexiletine with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Mexiletine with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Mexiletine with respect to specific gender populations.

Race

There is no FDA guidance on the use of Mexiletine with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Mexiletine in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Mexiletine in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Mexiletine in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Mexiletine in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Mexiletine in the drug label.

Condition1
  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Mexiletine in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Mexiletine in the drug label.

Pharmacology

There is limited information regarding Mexiletine Pharmacology in the drug label.

Mechanism of Action

Structure

This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Mexiletine in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Mexiletine in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Mexiletine in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Mexiletine in the drug label.

Condition1
  • Description

How Supplied

Storage

There is limited information regarding Mexiletine Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Mexiletine |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Mexiletine |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Mexiletine in the drug label.

Precautions with Alcohol

  • Alcohol-Mexiletine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)


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