Hydralazine tablet overdosage: Difference between revisions
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==OVERDOSAGE== | |||
===Acute Toxicity=== | |||
No deaths due to acute poisoning have been reported. Highest known dose survived: adults, 10 g orally. | |||
Oral LD50 in rats: 173 and 187 mg/kg. | |||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = HYDRALAZINE HYDROCHLORIDE TABLET [PLIVA INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ddbbdb09-3202-42d7-bbb0-08331dde2f54 | publisher = | date = | accessdate = 10 March 2014 }}</ref> | ====Signs and Symptoms==== | ||
Signs and symptoms of overdosage include [[hypotension]], [[tachycardia]], [[headache]], and generalized skin [[flushing]]. | |||
Complications can include [[myocardial ischemia]] and subsequent [[myocardial infarction]], cardiac [[arrhythmia]], and profound [[shock]]. | |||
====Treatment==== | |||
There is no specific antidote. | |||
The gastric contents should be evacuated, taking adequate precautions against aspiration and for protection of the airway. An activated charcoal slurry may be instilled if conditions permit. These manipulations may have to be omitted or carried out after cardiovascular status has been stabilized, since they might precipitate [[cardiac arrhythmias]] or increase the depth of shock. | |||
Support of the cardiovascular system is of primary importance. Shock should be treated with plasma expanders. If possible, [[vasopressors ]]should not be given, but if a vasopressor is required, care should be taken not to precipitate or aggravate cardiac arrhythmia. | |||
[[Tachycardia ]]responds to [[beta blockers]]. Digitalization may be necessary, and renal function should be monitored and supported as required. | |||
No experience has been reported with extracorporeal or [[peritoneal dialysis]].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = HYDRALAZINE HYDROCHLORIDE TABLET [PLIVA INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ddbbdb09-3202-42d7-bbb0-08331dde2f54 | publisher = | date = | accessdate = 10 March 2014 }}</ref> | |||
==References== | ==References== | ||
Revision as of 21:46, 10 March 2014
| Hydralazine |
|---|
| HYDRALAZINE tablet® FDA Package Insert |
| Indications and Usage |
| Dosage and Administration |
| Contraindications |
| Warnings |
| Precautions |
| Adverse Reactions |
| Drug Interactions |
| Use in Specific Populations |
| Overdosage |
| Description |
| Clinical Pharmacology |
| Nonclinical Toxicology |
| How Supplied/Storage and Handling |
| Labels and Packages |
| HYDRALAZINE injection® FDA Package Insert |
| Indications and Usage |
| Dosage and Administration |
| Contraindications |
| Warnings |
| Precautions |
| Adverse Reactions |
| Drug Interactions |
| Use in Specific Populations |
| Overdosage |
| Description |
| Clinical Pharmacology |
| Nonclinical Toxicology |
| How Supplied/Storage and Handling |
| Labels and Packages |
| Clinical Trials on Hydralazine |
| ClinicalTrials.gov |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdurahman Khalil, M.D. [2]
OVERDOSAGE
Acute Toxicity
No deaths due to acute poisoning have been reported. Highest known dose survived: adults, 10 g orally.
Oral LD50 in rats: 173 and 187 mg/kg.
Signs and Symptoms
Signs and symptoms of overdosage include hypotension, tachycardia, headache, and generalized skin flushing.
Complications can include myocardial ischemia and subsequent myocardial infarction, cardiac arrhythmia, and profound shock.
Treatment
There is no specific antidote.
The gastric contents should be evacuated, taking adequate precautions against aspiration and for protection of the airway. An activated charcoal slurry may be instilled if conditions permit. These manipulations may have to be omitted or carried out after cardiovascular status has been stabilized, since they might precipitate cardiac arrhythmias or increase the depth of shock.
Support of the cardiovascular system is of primary importance. Shock should be treated with plasma expanders. If possible, vasopressors should not be given, but if a vasopressor is required, care should be taken not to precipitate or aggravate cardiac arrhythmia.
Tachycardia responds to beta blockers. Digitalization may be necessary, and renal function should be monitored and supported as required.
No experience has been reported with extracorporeal or peritoneal dialysis.[1]
References
- ↑ "HYDRALAZINE HYDROCHLORIDE TABLET [PLIVA INC.]". Retrieved 10 March 2014.