Hydralazine (injection): Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
mNo edit summary
Line 1: Line 1:
__NOTOC__
{{DrugProjectFormSinglePage
{{Hydralazine}}
|authorTag=
{{CMG}}; {{AE}}


'''''For patient information about Hydralazine, click [[Hydralazine (patient information)|here]].'''''


{{SB}}
<!--Overview-->
HYDRALAZINE<sup>®</sup>
==Overview==
'''Hydralazine''' ('''apresoline''') is a direct-acting [[smooth muscle]] relaxant used to treat [[hypertension]] by acting as a [[vasodilator]] primarily in [[arteries]] and [[arterioles]].  By relaxing [[vascular smooth muscle]], vasodilators act to decrease [[peripheral resistance]], thereby lowering [[blood pressure]] and decreasing afterload.<ref name=Harvey>Harvey, Richard A., Pamela A. Harvey, and Mark J. Mycek. Lippincott's Illustrated Reviews: Pharmacology. 2nd ed. Philadelphia: Lipincott, Williams & Wilkins, 2000. 190.</ref>


However, this only has a short term effect on blood pressure, as the system will reset to the previous, high blood pressure necessary to maintain pressure in the kidney necessary for [[natriuresis]]. The long term effect of antihypertensive drugs comes from their effects on the pressure natriuresis curve.
|genericName=
==Category==
Nonsympatholytic nitrovasodilators.
==FDA Package Insert==


====HYDRALAZINE tablet<sup>®</sup>====


'''  [[Hydralazine tablet indications and usage|Indications and Usage]]'''
|aOrAn=
'''| [[Hydralazine tablet dosage and administration|Dosage and Administration]]'''
a
'''| [[Hydralazine tablet contraindications|Contraindications]]'''
'''| [[Hydralazine tablet warnings |Warnings]]'''
'''| [[Hydralazine tablet  precautions| Precautions]]'''
'''| [[Hydralazine tablet adverse reactions|Adverse Reactions]]'''
'''| [[Hydralazine tablet drug interactions|Drug Interactions]]'''
'''| [[Hydralazine tablet use in specific populations|Use in Specific Populations]]'''
'''| [[Hydralazine tablet overdosage|Overdosage]]'''
'''| [[Hydralazine tablet description|Description]]'''
'''| [[Hydralazine tablet clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Hydralazine tablet nonclinical toxicology|Nonclinical Toxicology]]'''
'''| [[Hydralazine tablet how supplied storage and handling|How Supplied/Storage and Handling]]'''
'''| [[Hydralazine tablet labels and packages|Labels and Packages]]'''


|drugClass=


====HYDRALAZINE injecton<sup>®</sup>====
'''  [[Hydralazine injection indications and usage|Indications and Usage]]'''
'''| [[Hydralazine injection dosage and administration|Dosage and Administration]]'''
'''| [[Hydralazine injection contraindications|Contraindications]]'''
'''| [[Hydralazine injection warnings |Warnings]]'''
'''| [[Hydralazine injection  precautions| Precautions]]'''
'''| [[Hydralazine injection adverse reactions|Adverse Reactions]]'''
'''| [[Hydralazine injection drug interactions|Drug Interactions]]'''
'''| [[Hydralazine injection use in specific populations|Use in Specific Populations]]'''
'''| [[Hydralazine injection overdosage|Overdosage]]'''
'''| [[Hydralazine injection description|Description]]'''
'''| [[Hydralazine injection clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Hydralazine injection nonclinical toxicology|Nonclinical Toxicology]]'''
'''| [[Hydralazine injection how supplied storage and handling|How Supplied/Storage and Handling]]'''
'''| [[Hydralazine injection labels and packages|Labels and Packages]]'''
==Mechanism of Action==
Although the precise mechanism of action of hydralazine is not fully understood, the major effects are on the cardiovascular system. Hydralazine apparently lowers blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle. Hydralazine, by altering cellular calcium metabolism, interferes with the calcium movements within the vascular smooth muscle that are responsible for initiating or maintaining the contractile state.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = HYDRALAZINE HYDROCHLORIDE TABLET [PLIVA INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ddbbdb09-3202-42d7-bbb0-08331dde2f54 | publisher =  | date =  | accessdate = 10 March 2014 }}</ref>
==References==


{{Reflist|2}}
|indication=
 
 
|hasBlackBoxWarning=
Yes
 
|adverseReactions=
 
 
<!--Black Box Warning-->
 
|blackBoxWarningTitle=
Title
 
|blackBoxWarningBody=
<i><span style="color:#FF0000;">ConditionName: </span></i>Content
 
 
<!--Adult Indications and Dosage-->
 
<!--FDA-Labeled Indications and Dosage (Adult)-->
 
|fdaLIADAdult=
 
=====Condition1=====
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
* Dosing Information
 
:* Dosage
 
=====Condition3=====
 
* Dosing Information
 
:* Dosage
 
=====Condition4=====
 
* Dosing Information
 
:* Dosage
 
<!--Off-Label Use and Dosage (Adult)-->
 
<!--Guideline-Supported Use (Adult)-->
 
|offLabelAdultGuideSupport=
 
=====Condition1=====
 
* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
 
<!--Non–Guideline-Supported Use (Adult)-->
 
|offLabelAdultNoGuideSupport=
 
=====Condition1=====
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
 
<!--Pediatric Indications and Dosage-->
 
<!--FDA-Labeled Indications and Dosage (Pediatric)-->
 
|fdaLIADPed=
 
=====Condition1=====
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>FDA-Labeled Use</i> of {{PAGENAME}} in pediatric patients.
 
 
<!--Off-Label Use and Dosage (Pediatric)-->
 
<!--Guideline-Supported Use (Pediatric)-->
 
|offLabelPedGuideSupport=
 
=====Condition1=====
 
* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
 
<!--Non–Guideline-Supported Use (Pediatric)-->
 
|offLabelPedNoGuideSupport=
 
=====Condition1=====
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
 
<!--Contraindications-->
 
|contraindications=
 
* Condition1
 
<!--Warnings-->
 
|warnings=
 
Description
 
<!--Adverse Reactions-->
 
<!--Clinical Trials Experience-->
 
|clinicalTrials=
 
There is limited information regarding <i>Clinical Trial Experience</i> of {{PAGENAME}} in the drug label.
 
======Central Nervous System======
 
 
 
======Cardiovascular======
 
 
 
======Respiratory======
 
 
 
======Gastrointestinal======
 
 
 
======Hypersensitivity======
 
 
 
======Miscellaneous======
 
 
 
<!--Postmarketing Experience-->
 
|postmarketing=
 
There is limited information regarding <i>Postmarketing Experience</i> of {{PAGENAME}} in the drug label.
 
======Central Nervous System======
 
 
 
======Cardiovascular======
 
 
 
======Respiratory======
 
 
 
======Gastrointestinal======
 
 
 
======Hypersensitivity======
 
 
 
======Miscellaneous======
 
 
 
<!--Drug Interactions-->
 
|drugInteractions=
 
* Drug
:* Description
 
<!--Use in Specific Populations-->
 
|useInPregnancyFDA=
* '''Pregnancy Category'''
 
|useInPregnancyAUS=
* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''
 
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of {{PAGENAME}} in women who are pregnant.
 
|useInLaborDelivery=
There is no FDA guidance on use of {{PAGENAME}} during labor and delivery.
 
 
|useInNursing=
There is no FDA guidance on the use of {{PAGENAME}} with respect to nursing mothers.
 
 
|useInPed=
There is no FDA guidance on the use of {{PAGENAME}} with respect to pediatric patients.
 
 
|useInGeri=
There is no FDA guidance on the use of {{PAGENAME}} with respect to geriatric patients.
 
 
|useInGender=
There is no FDA guidance on the use of {{PAGENAME}} with respect to specific gender populations.
 
 
|useInRace=
There is no FDA guidance on the use of {{PAGENAME}} with respect to specific racial populations.
 
 
|useInRenalImpair=
There is no FDA guidance on the use of {{PAGENAME}} in patients with renal impairment.
 
 
|useInHepaticImpair=
There is no FDA guidance on the use of {{PAGENAME}} in patients with hepatic impairment.
 
 
|useInReproPotential=
There is no FDA guidance on the use of {{PAGENAME}} in women of reproductive potentials and males.
 
 
|useInImmunocomp=
There is no FDA guidance one the use of {{PAGENAME}} in patients who are immunocompromised.
 
<!--Administration and Monitoring-->
 
|administration=
Oral
 
Intravenous
 
|monitoring=
 
There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.
 
=====Condition1=====
 
Description
 
<!--IV Compatibility-->
 
|IVCompat=
 
There is limited information regarding <i>IV Compatibility</i> of {{PAGENAME}} in the drug label.
 
<!--Overdosage-->
 
|overdose=
 
===Acute Overdose===
 
====Signs and Symptoms====
 
Description
 
====Management====
 
Description
 
===Chronic Overdose===
 
There is limited information regarding <i>Chronic Overdose</i> of {{PAGENAME}} in the drug label.
 
<!--Pharmacology-->
 
<!--Drugbox2-->
 
|drugBox=
 
<!--Mechanism of Action-->
 
|mechAction=
 
<!--Structure-->
 
|structure=
 
There is limited information regarding <i>Structure</i> of {{PAGENAME}} in the drug label.
 
<!--Pharmacodynamics-->
 
|PD=
There is limited information regarding <i>Pharmacodynamics</i> of {{PAGENAME}} in the drug label.
 
 
<!--Pharmacokinetics-->
 
|PK=
There is limited information regarding <i>Pharmacokinetics</i> of {{PAGENAME}} in the drug label.
 
<!--Nonclinical Toxicology-->
 
|nonClinToxic=
 
There is limited information regarding <i>Nonclinical Toxicology</i> of {{PAGENAME}} in the drug label.
 
<!--Clinical Studies-->
 
|clinicalStudies=
 
There is limited information regarding <i>Clinical Studies</i> of {{PAGENAME}} in the drug label.
 
=====Condition1=====
 
Description
 
<!--How Supplied-->
 
|howSupplied=
 
<!--Patient Counseling Information-->
 
|fdaPatientInfo=
 
There is limited information regarding <i>Patient Counseling Information</i> of {{PAGENAME}} in the drug label.
 
<!--Precautions with Alcohol-->
 
|alcohol=
Alcohol-{{PAGENAME}} interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
 
<!--Brand Names-->
 
|brandNames=
 
<!--Look-Alike Drug Names-->
 
|lookAlike=
* A® — B®<ref name="www.ismp.org">{{Cite web  | last =  | first =  | title = http://www.ismp.org | url = http://www.ismp.org | publisher =  | date =  }}</ref>
 
<!--Drug Shortage Status-->
 
|drugShortage=
}}
 
<!--Pill Image-->
 
{{PillImage
|fileName=No image.jpg|This image is provided by the National Library of Medicine.
|drugName=
|NDC=
|drugAuthor=
|ingredients=
|pillImprint=
|dosageValue=
|dosageUnit=
|pillColor=
|pillShape=
|pillSize=
|pillScore=
}}
 
<!--Label Display Image-->
 
{{LabelImage
|fileName=No image.jpg|This image is provided by the National Library of Medicine.
}}
 
<!--Category-->


[[Category:Cardiovascular Drugs]]
[[Category:Cardiovascular Drugs]]
[[Category:Drugs]]
[[Category:Drug]]

Revision as of 15:14, 4 July 2014

Hydralazine (injection)
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Black Box Warning

Title
See full prescribing information for complete Boxed Warning.
ConditionName: Content

Overview

Hydralazine (injection) is a that is FDA approved for the {{{indicationType}}} of . There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Hydralazine (injection) in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Hydralazine (injection) in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Hydralazine (injection) in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Hydralazine (injection) in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Hydralazine (injection) in pediatric patients.

Contraindications

  • Condition1

Warnings

Title
See full prescribing information for complete Boxed Warning.
ConditionName: Content

Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Hydralazine (injection) in the drug label.

Central Nervous System
Cardiovascular
Respiratory
Gastrointestinal
Hypersensitivity
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Hydralazine (injection) in the drug label.

Central Nervous System
Cardiovascular
Respiratory
Gastrointestinal
Hypersensitivity
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Hydralazine (injection) in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Hydralazine (injection) during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Hydralazine (injection) with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Hydralazine (injection) with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Hydralazine (injection) with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Hydralazine (injection) with respect to specific gender populations.

Race

There is no FDA guidance on the use of Hydralazine (injection) with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Hydralazine (injection) in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Hydralazine (injection) in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Hydralazine (injection) in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Hydralazine (injection) in patients who are immunocompromised.

Administration and Monitoring

Administration

Oral

Intravenous

Monitoring

There is limited information regarding Monitoring of Hydralazine (injection) in the drug label.

Condition1

Description

IV Compatibility

There is limited information regarding IV Compatibility of Hydralazine (injection) in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

Description

Management

Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Hydralazine (injection) in the drug label.

Pharmacology

There is limited information regarding Hydralazine (injection) Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Hydralazine (injection) Mechanism of Action in the drug label.

Structure

There is limited information regarding Structure of Hydralazine (injection) in the drug label.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Hydralazine (injection) in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Hydralazine (injection) in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Hydralazine (injection) in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Hydralazine (injection) in the drug label.

Condition1

Description

How Supplied

There is limited information regarding Hydralazine (injection) How Supplied in the drug label.

Storage

There is limited information regarding Hydralazine (injection) Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Hydralazine (injection) |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Hydralazine (injection) |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Hydralazine (injection) in the drug label.

Precautions with Alcohol

Alcohol-Hydralazine (injection) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Hydralazine (injection) Brand Names in the drug label.

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ "http://www.ismp.org". External link in |title= (help)


{{#subobject: 

 |Page Name=Hydralazine (injection)
 |Pill Name=No image.jpg
 |Drug Name=
 |Pill Ingred=|+sep=;
 |Pill Imprint=
 |Pill Dosage=
 |Pill Color=|+sep=;
 |Pill Shape=
 |Pill Size (mm)=
 |Pill Scoring=
 |Pill Image=
 |Drug Author=
 |NDC=

}}


{{#subobject: 

 |Label Page=Hydralazine (injection)
 |Label Name=No image.jpg

}}

Retrieved from "https://www.wikidoc.org/index.php?title=Hydralazine_(injection)&oldid=988302"