Ticagrelor contraindications: Difference between revisions
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====Active Bleeding==== | ====Active Bleeding==== | ||
BRILINTA is contraindicated in patients with active pathological bleeding such as peptic ulcer or [[intracranial hemorrhage]] [see Warnings and Precautions | BRILINTA is contraindicated in patients with active pathological bleeding such as [[peptic ulcer]] or [[intracranial hemorrhage]] ''[see [[Ticagrelor warnings and precautions|Warnings and Precautions]] and [[Ticagrelor adverse reactions|Adverse Reactions]]]''. | ||
====Severe Hepatic Impairment==== | ====Severe Hepatic Impairment==== | ||
Revision as of 22:53, 11 March 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2]
Contraindications
History of Intracranial Hemorrhage
BRILINTA is contraindicated in patients with a history of intracranial hemorrhage (ICH) because of a high risk of recurrent ICH in this population [see Clinical Studies].
Active Bleeding
BRILINTA is contraindicated in patients with active pathological bleeding such as peptic ulcer or intracranial hemorrhage [see Warnings and Precautions and Adverse Reactions].
Severe Hepatic Impairment
BRILINTA is contraindicated in patients with severe hepatic impairment because of a probable increase in exposure, and it has not been studied in these patients. Severe hepatic impairment increases the risk of bleeding because of reduced synthesis of coagulation proteins [see Clinical Pharmacology (12.3)].
Hypersensitivity
BRILINTA is contraindicated in patients with hypersensitivity (e.g. angioedema) to ticagrelor or any component of the product [see Adverse Reactions (6.2)].[1]