Lopressor/contraindications: Difference between revisions

Metoprolol
Clinical data
Trade names	Lopressor, Toprol-xl
AHFS/Drugs.com	Monograph
MedlinePlus	a682864
[[Regulation of therapeutic goods \|Template:Engvar data]]	US FDA: Metoprolol;
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	Oral, IV
ATC code	C07AB02 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	12%
Metabolism	Hepatic via CYP2D6, CYP3A4
Elimination half-life	3-7 hours
Excretion	Renal
Identifiers
	IUPAC name (RS)-1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol;
CAS Number	51384-51-1 ;
PubChem CID	4171;
IUPHAR/BPS	553;
DrugBank	DB00264 ;
ChemSpider	4027 ;
UNII	GEB06NHM23;
KEGG	D02358 ;
ChEBI	CHEBI:6904 ;
ChEMBL	ChEMBL13 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C15H25NO3
Molar mass	267.364 g/mol
3D model (JSmol)	Interactive image;
Melting point	120 °C (248 °F)
	SMILES O(c1ccc(cc1)CCOC)CC(O)CNC(C)C;
	InChI InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3 ; Key:IUBSYMUCCVWXPE-UHFFFAOYSA-N ;
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Revision as of 03:52, 13 March 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Lopressor is contraindicated in the following (see Warnings):

Hypersensitivity to Lopressor and related derivatives, or to any of the excipients; hypersensitivity to other beta blockers (cross sensitivity between beta blockers can occur).

Severe peripheral arterial circulatory disorders.

Lopressor is contraindicated in patients with the followings(see WARNINGS).^[1]:

Adapted from the FDA Package Insert.

@@ Line 5: / Line 5: @@
 ===Hypertension and Angina===
-Lopressor is contraindicated in the following (see WARNINGS):
+Lopressor is contraindicated in the following ''(see [[Lopressor warnings and precautions|Warnings]])'':
 * [[Sinus bradycardia]]
 * [[Heart block]] greater than [[First degree AV block|first degree]]
 * [[Cardiogenic shock]]
 * Overt [[cardiac failure]]
 * [[Hypersensitivity]] to Lopressor and related derivatives, or to any of the excipients; [[hypersensitivity]] to other [[beta blocker]]s (cross sensitivity between beta blockers can occur).