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===[[Toprol XL indications and usage|Indications and Usage]]===
===[[Disclaimer]]===
===[[Toprol XL black box warning|Black Box Warning]]===
===[[Toprol XL dosage and administration|Dosage and Administration]]===
===[[Toprol XL dosage and administration|Dosage and Administration]]===
===[[Toprol XL dosage forms and strengths|Dosage Forms and Strengths]]===
===[[Toprol XL dosage forms and strengths|Dosage Forms and Strengths]]===
===[[Toprol XL indications and usage|Indications and Usage]]===
===[[Toprol XL contraindications|Contraindications]]===
===[[Toprol XL contraindications|Contraindications]]===
===[[Toprol XL warnings and precautions|Warnings and Precautions]]===
===[[Toprol XL warnings and precautions|Warnings and Precautions]]===
Line 29: Line 31:
===[[Toprol XL overdosage|Overdosage]]===
===[[Toprol XL overdosage|Overdosage]]===
===[[Toprol XL description|Description]]===
===[[Toprol XL description|Description]]===
===[[Toprol XL mechanism of action|Mechanism of Action]]===
===[[Toprol XL clinical pharmacology|Clinical Pharmacology]]===
===[[Toprol XL clinical pharmacology|Clinical Pharmacology]]===
===[[Toprol XL nonclinical toxicology|Nonclinical Toxicology]]===
===[[Toprol XL nonclinical toxicology|Nonclinical Toxicology]]===

Revision as of 15:05, 14 March 2014

Metoprolol
Clinical data
Trade namesLopressor, Toprol-xl
AHFS/Drugs.comMonograph
MedlinePlusa682864
[[Regulation of therapeutic goods |Template:Engvar data]]
Pregnancy
category
  • AU: C
  • US: C (Risk not ruled out)
Routes of
administration		Oral, IV
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability12%
MetabolismHepatic via CYP2D6, CYP3A4
Elimination half-life3-7 hours
ExcretionRenal
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC15H25NO3
Molar mass267.364 g/mol
3D model (JSmol)
Melting point120 °C (248 °F)
  (verify)

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

WARNING: ISCHEMIC HEART DISEASE

See full prescribing information for complete boxed warning.


Following abrupt cessation of therapy with certain beta-blocking agents, exacerbations of angina pectoris and, in some cases, myocardial infarction have occurred. When discontinuing chronically administered TOPROL-XL, particularly in patients with ischemic heart disease, the dosage should be gradually reduced over a period of 1 - 2 weeks and the patient should be carefully monitored. If angina markedly worsens or acute coronary insufficiency develops, TOPROL-XL administration should be reinstated promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. Warn patients against interruption or discontinuation of therapy without the physician’s advice. Because coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue TOPROL-XL therapy abruptly even in patients treated only for hypertension.

Disclaimer

Black Box Warning

Dosage and Administration

Dosage Forms and Strengths

Indications and Usage

Contraindications

Warnings and Precautions

Adverse Reactions

Drug Interactions

Use in Specific Populations

Overdosage

Description

Mechanism of Action

Clinical Pharmacology

Nonclinical Toxicology

Clinical Studies

How Supplied/Storage and Handling

Patient Counseling Information

Labels and Packages

Pill Images

References

Adapted from the FDA Package Insert.

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