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|Prompt=A 6-year-old African American male is brought to the emergency room for severe abdominal pain. On examination, his abdomen is stiff and bloated with diffuse pain, but most severe in the upper left quadrant. This is the second time such episode happens for this patient and one of his older sisters suffered a similar disease. After supportive treatment, this patient must receive a vaccine for a certain encapsulated, catalase-positive gram negative rod. What moiety is used in this vaccine? | |Prompt=A 6-year-old African American male is brought to the emergency room for severe abdominal pain. On examination, his abdomen is stiff and bloated with diffuse pain, but most severe in the upper left quadrant. This is the second time such episode happens for this patient and one of his older sisters suffered a similar disease. After supportive treatment, this patient must receive a vaccine for a certain encapsulated, catalase-positive gram negative rod. What moiety is used in this vaccine? | ||
|Explanation=The patient in this vignette suffers from [[sickle-cell anemia]]. Sickle-cell anemia is an [[autosomal recessive]] condition mainly affecting patients of African American and Middle-Eastern ancestry. Patients with sickle-cell anemia suffer from vaso-occlusive crisis, splenic sequestration crisis, [[aplastic crisis]] and hemolytic crisis. All of these clinical scenarios are caused by aggregation of sickled red cells and tend to be brought on by conditions of stress or infection. In this vignette, the patient is suffering from a splenic sequestration crisis. Because of its narrow vessels and function in clearing defective [[red blood cells]], the [[spleen]] is frequently affected. It is usually infarcted before the end of childhood in individuals suffering from [[sickle-cell anemia]]. Splenic sequestration crises are acute, painful enlargements of the spleen. The sinusoids and gates would open at the same time resulting in sudden pooling of the blood into the spleen and circulatory defect leading to sudden [[hypovolemia]]. The abdomen becomes bloated and very hard. Splenic sequestration crises are considered an emergency. | |Explanation=The patient in this vignette suffers from [[sickle-cell anemia]]. Sickle-cell anemia is an [[autosomal recessive]] condition mainly affecting patients of African American and Middle-Eastern ancestry. Patients with sickle-cell anemia suffer from vaso-occlusive crisis, splenic sequestration crisis, [[aplastic crisis]] and hemolytic crisis. All of these clinical scenarios are caused by aggregation of sickled red cells and tend to be brought on by conditions of stress or infection. In this vignette, the patient is suffering from a splenic sequestration crisis. Because of its narrow vessels and function in clearing defective [[red blood cells]], the [[spleen]] is frequently affected. It is usually infarcted before the end of childhood in individuals suffering from [[sickle-cell anemia]]. Splenic sequestration crises are acute, painful enlargements of the spleen. The sinusoids and gates would open at the same time resulting in sudden pooling of the blood into the spleen and circulatory defect leading to sudden [[hypovolemia]]. The abdomen becomes bloated and very hard. Splenic sequestration crises are considered an emergency. | ||
After [[splenectomy]], sickle cell patients must receive [[vaccine]]s to prevent infection with encapsulated organisms including [[Streptococcus pneumoniae]], [[Neisseria meningitidis]] and [[Haemophilus | After [[splenectomy]], sickle cell patients must receive [[vaccine]]s to prevent infection with encapsulated organisms including [[Streptococcus pneumoniae]], [[Neisseria meningitidis]] and [[Haemophilus influenzae]] type B. [[Haemophilus influenzae]] type B is an encapsulated, [[gram negative]] rod which can cause severe [[meningitis]] in infants and children. The vaccine for this organism is a conjugate vaccine that uses the bacterial capsular polysaccharide polyribosylribitol phosphate conjugated with a protein to stimulate long term [[humoral immunity]]. | ||
|AnswerA=Polyribosylribitol phosphate | |AnswerA=Polyribosylribitol phosphate | ||
|AnswerAExp=The vaccine for [[Haemophilus | |AnswerAExp=The vaccine for [[Haemophilus influenzae]] type B is a conjugate vaccine that uses the bacterial capsular polysaccharide polyribosylribitol phosphate conjugated with a protein to stimulate long term [[humoral immunity]]. | ||
|AnswerB=Peptidoglycan | |AnswerB=Peptidoglycan | ||
|AnswerBExp=[[Peptidoglycan]] composes the membrane of most bacteria. It is not used in the [[Haemophilus | |AnswerBExp=[[Peptidoglycan]] composes the membrane of most bacteria. It is not used in the [[Haemophilus influenzae]] type B vaccine. | ||
|AnswerC=Protein A | |AnswerC=Protein A | ||
|AnswerCExp=[[Protein A]] is a virulence factor of [[S. aureus]] which binds to the Fc portion of Ig and helps to prevent opsonization and phagocytosis. It is not used in the [[Haemophilus | |AnswerCExp=[[Protein A]] is a virulence factor of [[S. aureus]] which binds to the Fc portion of Ig and helps to prevent opsonization and phagocytosis. It is not used in the [[Haemophilus influenzae]] type B vaccine. | ||
|AnswerD=Lipid A | |AnswerD=Lipid A | ||
|AnswerDExp=[[Lipid A]] is a part of [[endotoxin]], a lipopolysaccharide which is a highly immunogenic component of the cell wall of gram-negative bacteria. It is not used in the [[Haemophilus | |AnswerDExp=[[Lipid A]] is a part of [[endotoxin]], a lipopolysaccharide which is a highly immunogenic component of the cell wall of gram-negative bacteria. It is not used in the [[Haemophilus influenzae]] type B vaccine. | ||
|AnswerE=M protein | |AnswerE=M protein | ||
|AnswerEExp=[[M protein]] is a virulence factor of [[Strep pyogenes]] that helps prevent [[phagocytosis]]. It is not used in the [[Haemophilus | |AnswerEExp=[[M protein]] is a virulence factor of [[Strep pyogenes]] that helps prevent [[phagocytosis]]. It is not used in the [[Haemophilus influenzae]] type B vaccine. | ||
|EducationalObjectives=The vaccine for this [[Haemophilus | |EducationalObjectives=The vaccine for this [[Haemophilus influenzae]] B is a conjugate vaccine that uses the bacterial capsular polysaccharide polyribosylribitol phosphate conjugated with a [[protein]] to stimulate long term humoral immunity. | ||
|References=First Aid 2014 page 137 | |References=First Aid 2014 page 137 | ||
Revision as of 22:27, 15 March 2014
| Author | [[PageAuthor::William J Gibson (Reviewed by Rim Halaby, M.D. [1])]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Genetics, MainCategory::Immunology, MainCategory::Microbiology |
| Sub Category | SubCategory::Vascular, SubCategory::General Principles, SubCategory::Infectious Disease |
| Prompt | [[Prompt::A 6-year-old African American male is brought to the emergency room for severe abdominal pain. On examination, his abdomen is stiff and bloated with diffuse pain, but most severe in the upper left quadrant. This is the second time such episode happens for this patient and one of his older sisters suffered a similar disease. After supportive treatment, this patient must receive a vaccine for a certain encapsulated, catalase-positive gram negative rod. What moiety is used in this vaccine?]] |
| Answer A | AnswerA::Polyribosylribitol phosphate |
| Answer A Explanation | [[AnswerAExp::The vaccine for Haemophilus influenzae type B is a conjugate vaccine that uses the bacterial capsular polysaccharide polyribosylribitol phosphate conjugated with a protein to stimulate long term humoral immunity.]] |
| Answer B | AnswerB::Peptidoglycan |
| Answer B Explanation | [[AnswerBExp::Peptidoglycan composes the membrane of most bacteria. It is not used in the Haemophilus influenzae type B vaccine.]] |
| Answer C | AnswerC::Protein A |
| Answer C Explanation | [[AnswerCExp::Protein A is a virulence factor of S. aureus which binds to the Fc portion of Ig and helps to prevent opsonization and phagocytosis. It is not used in the Haemophilus influenzae type B vaccine.]] |
| Answer D | AnswerD::Lipid A |
| Answer D Explanation | [[AnswerDExp::Lipid A is a part of endotoxin, a lipopolysaccharide which is a highly immunogenic component of the cell wall of gram-negative bacteria. It is not used in the Haemophilus influenzae type B vaccine.]] |
| Answer E | AnswerE::M protein |
| Answer E Explanation | [[AnswerEExp::M protein is a virulence factor of Strep pyogenes that helps prevent phagocytosis. It is not used in the Haemophilus influenzae type B vaccine.]] |
| Right Answer | RightAnswer::A |
| Explanation | [[Explanation::The patient in this vignette suffers from sickle-cell anemia. Sickle-cell anemia is an autosomal recessive condition mainly affecting patients of African American and Middle-Eastern ancestry. Patients with sickle-cell anemia suffer from vaso-occlusive crisis, splenic sequestration crisis, aplastic crisis and hemolytic crisis. All of these clinical scenarios are caused by aggregation of sickled red cells and tend to be brought on by conditions of stress or infection. In this vignette, the patient is suffering from a splenic sequestration crisis. Because of its narrow vessels and function in clearing defective red blood cells, the spleen is frequently affected. It is usually infarcted before the end of childhood in individuals suffering from sickle-cell anemia. Splenic sequestration crises are acute, painful enlargements of the spleen. The sinusoids and gates would open at the same time resulting in sudden pooling of the blood into the spleen and circulatory defect leading to sudden hypovolemia. The abdomen becomes bloated and very hard. Splenic sequestration crises are considered an emergency.
After splenectomy, sickle cell patients must receive vaccines to prevent infection with encapsulated organisms including Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae type B. Haemophilus influenzae type B is an encapsulated, gram negative rod which can cause severe meningitis in infants and children. The vaccine for this organism is a conjugate vaccine that uses the bacterial capsular polysaccharide polyribosylribitol phosphate conjugated with a protein to stimulate long term humoral immunity. First Aid 2012 page 150]] |
| Approved | Approved::Yes |
| Keyword | WBRKeyword::Microbiology, WBRKeyword::Bacteria, WBRKeyword::Vaccine, WBRKeyword::Sickle, WBRKeyword::Sickle cell, WBRKeyword::Sickle cell anemia, WBRKeyword::Sickle cell disease |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |