Bumetanide (injection)

Bumetanide (injection)
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]

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Black Box Warning

WARNING See full prescribing information for complete Boxed Warning. Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required, and dose and dosage schedule have to be adjusted to the individual patient’s needs (see DOSAGE AND ADMINISTRATION).

Overview

Bumetanide (injection) is {{{aOrAn}}} loop diuretic that is FDA approved for the {{{indicationType}}} of edema associated with congestive heart failure, hepatic and renal disease, including the nephrotic syndrome,. There is a Black Box Warning for this drug as shown here. Common adverse reactions include Hypotension, hyperuricemia, hypochloremia, hypokalemia, nausea, cramp, dizziness, headache, azotemia.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Dosage should be individualized with careful monitoring of patient response.

Oral Administration

• Dosing Information

• Usual dosage: 0.5-2 mg PO qd {maximum daily dose of 10 mg}

Parenteral Administration

• Dosing Information

• usual initial dosage: 0.5 to 1 mg IV or IM

Off-Label Use and Dosage (Adult)

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding Bumetanide (injection) FDA-Labeled Indications and Dosage (Pediatric) in the drug label.

Off-Label Use and Dosage (Pediatric)

Contraindications

There is limited information regarding Bumetanide (injection) Contraindications in the drug label.

Warnings

WARNING See full prescribing information for complete Boxed Warning. Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required, and dose and dosage schedule have to be adjusted to the individual patient’s needs (see DOSAGE AND ADMINISTRATION).

There is limited information regarding Bumetanide (injection) Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Bumetanide (injection) Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Bumetanide (injection) Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Bumetanide (injection) Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Bumetanide (injection) in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Bumetanide (injection) in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Bumetanide (injection) during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Bumetanide (injection) in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Bumetanide (injection) in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Bumetanide (injection) in geriatric settings.

Gender

There is no FDA guidance on the use of Bumetanide (injection) with respect to specific gender populations.

Race

There is no FDA guidance on the use of Bumetanide (injection) with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Bumetanide (injection) in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Bumetanide (injection) in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Bumetanide (injection) in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Bumetanide (injection) in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Bumetanide (injection) Administration in the drug label.

Monitoring

There is limited information regarding Bumetanide (injection) Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Bumetanide (injection) and IV administrations.

Overdosage

There is limited information regarding Bumetanide (injection) overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Bumetanide (injection) Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Bumetanide (injection) Mechanism of Action in the drug label.

Structure

There is limited information regarding Bumetanide (injection) Structure in the drug label.

Pharmacodynamics

There is limited information regarding Bumetanide (injection) Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Bumetanide (injection) Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Bumetanide (injection) Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Bumetanide (injection) Clinical Studies in the drug label.

How Supplied

There is limited information regarding Bumetanide (injection) How Supplied in the drug label.

Storage

There is limited information regarding Bumetanide (injection) Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Bumetanide (injection) Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Bumetanide (injection) interaction has not been established. Talk to your doctor regarding the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Bumetanide (injection) Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Bumetanide (injection) Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.