DVT complete diagnostic approach resident survival guide: Difference between revisions
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==Complete Diagnostic Approach== | |||
{{ | A complete diagnostic approach should be carried out after a focused initial rapid evaluation is conducted and following initiation of any urgent intervention.<ref name="pmid22315267">{{cite journal| author=Bates SM, Jaeschke R, Stevens SM, Goodacre S, Wells PS, Stevenson MD et al.| title=Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. | journal=Chest | year= 2012 | volume= 141 | issue= 2 Suppl | pages= e351S-418S | pmid=22315267 | doi=10.1378/chest.11-2299 | pmc=PMC3278048 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22315267 }} </ref> | ||
{{familytree | | | | | | | | <span style="font-size:85%"> </span> | ||
{{Family tree/start}} | |||
{{familytree | | | | | | | A01 | | A01=<div style="float: left; text-align: left; width: 35em; padding:1em;"> '''Characterize the symptoms in the involved extremity:''' <br> | |||
❑ Swelling <br> | |||
❑ Pain <br> | |||
❑ Erythema <br> | |||
{{familytree | | | | | ❑ Warmth<br></div>}} | ||
{{familytree | | | | {{familytree | | | | | | | |!| | |}} | ||
{{familytree | | | | | | | B01 | | B01= | |||
<div style="float: left; text-align: left; width: 35em; padding:1em;"> | |||
{{familytree | | | | '''Identify possible precipitating factors:'''<br> | ||
{{familytree | | | | ❑ Recent surgery <br> | ||
❑ Hospitalization <br> | |||
{{familytree | | | | | ❑ [[Trauma]] <br> | ||
{{familytree | |,|-| | ❑ [[Pregnancy]] <br> | ||
{{ | ❑ [[Postpartum]] <br> | ||
{{ | ❑ [[Heart failure]] <br> | ||
❑ Immobility<br> | |||
❑ Obesity<br> | |||
❑ [[Malignancy]]<br> | |||
❑ [[Stroke]] <br> | |||
{ | ❑ [[Oral contraceptive]] or [[hormone replacement therapy]] | ||
---- | |||
'''Obtain a detailed history:''' <br> | |||
❑ Previous episode of VTE | |||
{{ | :❑ Age | ||
:❑ Location | |||
❑ Past medical history: | |||
:❑ [[Collagen vascular disease]] | |||
:❑ [[Myeloproliferative disease]] | |||
:❑ [[Nephrotic syndrome]] | |||
:❑ [[Atherosclerosis]] | |||
❑ Abortion at second or third trimester of pregancy (suggestive of an inherited thrombophilia or APS)<br> | |||
❑ Drugs that may induce APS | |||
:❑ [[Hydralazine]] | |||
:❑ [[Phenothiazine]] | |||
:❑ [[Procainamide]] | |||
</div>}} | |||
{{familytree | | | | | | | |!| | | }} | |||
{{familytree | | | | | | | C01 | | C01=<div style="float: left; text-align: left; width: 35em; padding:1em;">'''Examine the patient:''' <br> | |||
'''Vital signs''' <br> | |||
❑ | |||
</div>}} | |||
{{familytree | | | | | | | |!| | | }} | |||
{{familytree | | | | | | | D01 | | D01= <div style="float: left; text-align: left; width: 35em; padding:1em;">'''[[Deep vein thrombosis resident survival guide#Assessment of the Pre-Test Probability of DVT|Assess the pretest probability of DVT]]'''<br> ([[Deep vein thrombosis resident survival guide#Assessment of the Pre-Test Probability of DVT|Wells score shown below]])</div>}} | |||
{{familytree | | | | | | | |!| | | }} | |||
{{familytree | | | | | | | E01 | | E01= | |||
<div style="float: left; text-align: left; width: 35em; padding:1em;">'''Consider alternative diagnoses:''' <br> | |||
❑ [[Muscle strain]] or [[muscle tear]] <br> | |||
❑ [[Immobilization]] that led to leg swelling <br> | |||
❑ [[Lymphedema]] <br> | |||
❑ [[Lymphangitis]] <br> | |||
❑ [[Venous valvular insufficiency]] <br> | |||
❑ [[Baker's cyst]] <br> | |||
❑ [[Cellulitis]] <br> | |||
❑ [[Superficial thrombophlebitis]] | |||
</div>}} | |||
{{familytree | | | | | | | |!| | | }} | |||
{{familytree | | | | | | | F01 | | F01= | |||
<div style="float: left; text-align: left; width: 35em; padding:1em;">'''Order tests:''' <br> | |||
❑ [[CBC-D]] <br> | |||
❑ [[PT]] and [[aPTT]] | |||
❑ [[Creatinine]] (to rule out nephrotic syndrome) | |||
❑ [[Liver function test]] </div> }} | |||
{{familytree | | | | | | | |!| | | }} | |||
{{familytree | | | | | | | K01 | | | | | | K01= Is the suspected DVT a first or a recurrent episode?}} | |||
{{familytree | | | | | |,|-|^|-|.| | | | | }} | |||
{{familytree | | | | | L01 | | L02 | | |L01= First suspected episode| L02= Suspected recurrent episode}} | |||
{{familytree | | | | | |!| | | |!| | | | | }} | |||
{{familytree | | | | | M01 | | M02 | | | | M01= <div style="float: left; text-align: left; width: 35em; padding:1em;">'''[[Deep vein thrombosis resident survival guide#Assessment of the Pre-Test Probability of DVT|Assess the pretest probability of DVT]]'''<br> ([[Deep vein thrombosis resident survival guide#Assessment of the Pre-Test Probability of DVT|Wells score shown below]])| M02= ([[Deep vein thrombosis resident survival guide#Complete Diagnostic Approach for Suspected Recurrent Lower Extremity DVT|Click here for the diagnostic approach]])</div>}} | |||
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | }} | |||
{{familytree | N01 | | N02 | | N03 | | | | N01= Low pretest probability<br>([[Deep vein thrombosis resident survival guide#Low Pretest Probability|Click here for the diagnostic approach]])| N02= Moderate pretest probability<br>([[Deep vein thrombosis resident survival guide#ModeratePretest Probability|Click here for the diagnostic approach]])| N03= High pretest probability<br>([[Deep vein thrombosis resident survival guide#High Pretest Probability|Click here for the diagnostic approach]])}} | |||
{{Family tree/end}} | |||
===Assessment of the Pre-Test Probability of DVT=== | |||
====Calculation of Wells Score for DVT==== | |||
{| style="cellpadding=0; cellspacing= 0; width: 600px;" | |||
|- | |||
| style="padding: 0 5px; font-size: 100%; background: #F5F5F5;" align=center | '''Variables'''||style="padding: 0 5px; font-size: 100%; background: #F5F5F5;" align=center | '''Score'''<ref name="pmid16403932">{{cite journal| author=Wells PS, Owen C, Doucette S, Fergusson D, Tran H| title=Does this patient have deep vein thrombosis? | journal=JAMA | year= 2006 | volume= 295 | issue= 2 | pages= 199-207 | pmid=16403932 | doi=10.1001/jama.295.2.199 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16403932 }} [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17213132 Review in: Evid Based Med. 2006 Aug;11(4):119] [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16813372 Review in: ACP J Club. 2006 Jul-Aug;145(1):24] </ref> | |||
|- | |||
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Active cancer with either palliative therapy or treatment that is either ongoing or within the prior 6 months|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1 | |||
|- | |||
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Patient was recently bedridden for at least 3 days<br> OR Major surgery in the prior 12 weeks necessitating general or regional anesthesia|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1 | |||
|- | |||
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Recent plaster immobilization, paresis or paralysis of the lower extremities|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1 | |||
|- | |||
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Tenderness that is localized is the distribution of the deep veins|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1 | |||
|- | |||
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Leg is entirely swollen|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1 | |||
|- | |||
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Calf is swollen for 3 cm or move compared to the other calf|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1 | |||
|- | |||
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Pitting edema in the symptomatic leg|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1 | |||
|- | |||
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Presence of collateral superficial veins|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1 | |||
|- | |||
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Previous DVT|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1 | |||
|- | |||
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |There is an alternative diagnosis as likely as DVT|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |-2 | |||
|- | |||
|} | |||
====Interpretation of Wells Score for DVT==== | |||
{| style="cellpadding=0; cellspacing= 0; width: 600px;" | |||
|- | |||
| style="padding: 0 5px; font-size: 100%; background: #F5F5F5;" align=center | '''Score'''||style="padding: 0 5px; font-size: 100%; background: #F5F5F5;" align=center | '''Pretest probability'''<ref name="pmid16403932">{{cite journal| author=Wells PS, Owen C, Doucette S, Fergusson D, Tran H| title=Does this patient have deep vein thrombosis? | journal=JAMA | year= 2006 | volume= 295 | issue= 2 | pages= 199-207 | pmid=16403932 | doi=10.1001/jama.295.2.199 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16403932 }} [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17213132 Review in: Evid Based Med. 2006 Aug;11(4):119] [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16813372 Review in: ACP J Club. 2006 Jul-Aug;145(1):24] </ref><ref name="pmid9428249">{{cite journal| author=Wells PS, Anderson DR, Bormanis J, Guy F, Mitchell M, Gray L et al.| title=Value of assessment of pretest probability of deep-vein thrombosis in clinical management. | journal=Lancet | year= 1997 | volume= 350 | issue= 9094 | pages= 1795-8 | pmid=9428249 | doi=10.1016/S0140-6736(97)08140-3 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9428249 }} </ref> | |||
|- | |||
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |≥3 ||style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | High | |||
|- | |||
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1 or 2 ||style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Moderate | |||
|- | |||
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |0 or less ||style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Low | |||
|} | |||
====Modified Well Score==== | |||
<ref name="pmid14507948">{{cite journal| author=Wells PS, Anderson DR, Rodger M, Forgie M, Kearon C, Dreyer J et al.| title=Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. | journal=N Engl J Med | year= 2003 | volume= 349 | issue= 13 | pages= 1227-35 | pmid=14507948 | doi=10.1056/NEJMoa023153 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14507948 }} [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15122830 Review in: ACP J Club. 2004 May-Jun;140(3):67] </ref> Normal 0 false false false EN-US X-NONE X-NONE |
Revision as of 13:32, 22 May 2014
Complete Diagnostic Approach
A complete diagnostic approach should be carried out after a focused initial rapid evaluation is conducted and following initiation of any urgent intervention.[1]
Characterize the symptoms in the involved extremity: ❑ Swelling | |||||||||||||||||||||||||||||
Identify possible precipitating factors: Obtain a detailed history:
❑ Past medical history: ❑ Abortion at second or third trimester of pregancy (suggestive of an inherited thrombophilia or APS) | |||||||||||||||||||||||||||||
Examine the patient: Vital signs
| |||||||||||||||||||||||||||||
Consider alternative diagnoses: ❑ Muscle strain or muscle tear | |||||||||||||||||||||||||||||
Order tests: ❑ CBC-D | |||||||||||||||||||||||||||||
Is the suspected DVT a first or a recurrent episode? | |||||||||||||||||||||||||||||
First suspected episode | Suspected recurrent episode | ||||||||||||||||||||||||||||
(Click here for the diagnostic approach) | |||||||||||||||||||||||||||||
Low pretest probability (Click here for the diagnostic approach) | Moderate pretest probability (Click here for the diagnostic approach) | High pretest probability (Click here for the diagnostic approach) | |||||||||||||||||||||||||||
Assessment of the Pre-Test Probability of DVT
Calculation of Wells Score for DVT
Variables | Score[2] |
Active cancer with either palliative therapy or treatment that is either ongoing or within the prior 6 months | 1 |
Patient was recently bedridden for at least 3 days OR Major surgery in the prior 12 weeks necessitating general or regional anesthesia |
1 |
Recent plaster immobilization, paresis or paralysis of the lower extremities | 1 |
Tenderness that is localized is the distribution of the deep veins | 1 |
Leg is entirely swollen | 1 |
Calf is swollen for 3 cm or move compared to the other calf | 1 |
Pitting edema in the symptomatic leg | 1 |
Presence of collateral superficial veins | 1 |
Previous DVT | 1 |
There is an alternative diagnosis as likely as DVT | -2 |
Interpretation of Wells Score for DVT
Score | Pretest probability[2][3] |
≥3 | High |
1 or 2 | Moderate |
0 or less | Low |
Modified Well Score
[4] Normal 0 false false false EN-US X-NONE X-NONE
- ↑ Bates SM, Jaeschke R, Stevens SM, Goodacre S, Wells PS, Stevenson MD; et al. (2012). "Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines". Chest. 141 (2 Suppl): e351S–418S. doi:10.1378/chest.11-2299. PMC 3278048. PMID 22315267.
- ↑ 2.0 2.1 Wells PS, Owen C, Doucette S, Fergusson D, Tran H (2006). "Does this patient have deep vein thrombosis?". JAMA. 295 (2): 199–207. doi:10.1001/jama.295.2.199. PMID 16403932. Review in: Evid Based Med. 2006 Aug;11(4):119 Review in: ACP J Club. 2006 Jul-Aug;145(1):24
- ↑ Wells PS, Anderson DR, Bormanis J, Guy F, Mitchell M, Gray L; et al. (1997). "Value of assessment of pretest probability of deep-vein thrombosis in clinical management". Lancet. 350 (9094): 1795–8. doi:10.1016/S0140-6736(97)08140-3. PMID 9428249.
- ↑ Wells PS, Anderson DR, Rodger M, Forgie M, Kearon C, Dreyer J; et al. (2003). "Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis". N Engl J Med. 349 (13): 1227–35. doi:10.1056/NEJMoa023153. PMID 14507948. Review in: ACP J Club. 2004 May-Jun;140(3):67