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| __NOTOC__
| | #Redirect [[Yersinia pestis infection future or investigational therapies]] |
| {{Pneumonic plague}}
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| {{CMG}}
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| ==Overview==
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| The main investigational technique being looked into is that of a vaccine to stop any possible plague outbreaks. Currently, there is not an available vaccine against the plague, particularly the pneumonic version. This all may be changing because there has been research conducted giving promising results for a vaccine against the pneumonic plague.
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| ==Future and Investigational Therapies==
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| ===Pneumonic Plague Vaccine===
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| Before recently, there were attempts to make a possible [[vaccine]] from a live form of the virus. Unfortunately, the live ''Y.Pestis'' strain is genetically unstable, which does not make it suitable for a vaccination.<ref name="pmid22348169">{{cite journal |author=Derbise A, Cerdà Marín A, Ave P, Blisnick T, Huerre M, Carniel E, Demeure CE |title=An Encapsulated Yersinia pseudotuberculosis Is a Highly Efficient Vaccine against Pneumonic Plague |journal=[[PLoS Neglected Tropical Diseases]] |volume=6 |issue=2 |pages=e1528 |year=2012 |month=February |pmid=22348169 |pmc=3279354 |doi=10.1371/journal.pntd.0001528 |url=http://dx.plos.org/10.1371/journal.pntd.0001528 |accessdate=2012-03-02}}</ref> Instead of using the unstable ''Y.Pestis'' a research group decided to create a strain of the ''Y. pseudotuberculosis'' gene which shares more than 95% of its genetic identity with ''Y.Pestis.'' <ref name="pmid22348169">{{cite journal |author=Derbise A, Cerdà Marín A, Ave P, Blisnick T, Huerre M, Carniel E, Demeure CE |title=An Encapsulated Yersinia pseudotuberculosis Is a Highly Efficient Vaccine against Pneumonic Plague |journal=[[PLoS Neglected Tropical Diseases]] |volume=6 |issue=2 |pages=e1528 |year=2012 |month=February |pmid=22348169 |pmc=3279354 |doi=10.1371/journal.pntd.0001528 |url=http://dx.plos.org/10.1371/journal.pntd.0001528 |accessdate=2012-03-02}}</ref>. This gene is far more stable and it has shown promising results as a an oral vaccine for the plague. This vaccine has become a good candidate for helping stop the spread and mortality of pneumonic plague.<ref name="pmid22348169">{{cite journal |author=Derbise A, Cerdà Marín A, Ave P, Blisnick T, Huerre M, Carniel E, Demeure CE |title=An Encapsulated Yersinia pseudotuberculosis Is a Highly Efficient Vaccine against Pneumonic Plague |journal=[[PLoS Neglected Tropical Diseases]] |volume=6 |issue=2 |pages=e1528 |year=2012 |month=February |pmid=22348169 |pmc=3279354 |doi=10.1371/journal.pntd.0001528 |url=http://dx.plos.org/10.1371/journal.pntd.0001528 |accessdate=2012-03-02}}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Bacterial diseases]]
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| [[Category:Infectious disease]]
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| [[Category:Epidemics]]
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| [[Category:Pandemics]]
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| [[Category:Zoonoses]]
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| [[Category:Insect-borne diseases]]
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| [[Category:Disease]]
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