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====Classification of Disease Severity====
{| style="border: 2px solid #DCDCDC; font-size: 90%; width: 80%;"
! style="background: #DCDCDC;" | Severity
! style="background: #DCDCDC;" | Definition
|-
! style="background: #F5F5F5; padding: 10px 10px;" | Mild
| style="background: #F5F5F5; padding: 10px 10px;" valign=top | CDI with diarrhea as the only symptom.
|-
! style="background: #F5F5F5; padding: 10px 10px;" | Moderate
| style="background: #F5F5F5; padding: 10px 10px;" valign=top | CDI with diarrhea but without additional symptoms/signs meeting the definition of severe or complicated CDI.
|-
! style="background: #F5F5F5; padding: 10px 10px;" | Severe
| style="background: #F5F5F5; padding: 10px 10px;" valign=top | CDI that presents with or develops during the course of the disease with hypoalbuminemia (serum albumin < 3 g/dl) '''<u>and</u>''' either of the following:
* A white blood cell (WBC) count ≥15,000 cells/mm<sup>3</sup>
* Abdominal tenderness without criteria of complicated disease
|-
! style="background: #F5F5F5; padding: 10px 10px;" | Complicated
| style="background: #F5F5F5; padding: 10px 10px;" valign=top | CDI that presents with or develops at least one of the following signs or symptoms:
* Admission to intensive care unit
* Hypotension with or without required use of vasopressors
* Fever ≥38.5°C
* Ileus or significant abdominal distention
* Mental status changes
* WBC ≥35,000 cells/mm3 or &lt;2,000 cells/ mm3
* Serum lactate levels &gt;2.2 mmol/l
* Any evidence of end organ failure
|}

Revision as of 20:11, 4 June 2014


Classification of Disease Severity

Severity Definition
Mild CDI with diarrhea as the only symptom.
Moderate CDI with diarrhea but without additional symptoms/signs meeting the definition of severe or complicated CDI.
Severe CDI that presents with or develops during the course of the disease with hypoalbuminemia (serum albumin < 3 g/dl) and either of the following:
  • A white blood cell (WBC) count ≥15,000 cells/mm3
  • Abdominal tenderness without criteria of complicated disease
Complicated CDI that presents with or develops at least one of the following signs or symptoms:
  • Admission to intensive care unit
  • Hypotension with or without required use of vasopressors
  • Fever ≥38.5°C
  • Ileus or significant abdominal distention
  • Mental status changes
  • WBC ≥35,000 cells/mm3 or <2,000 cells/ mm3
  • Serum lactate levels >2.2 mmol/l
  • Any evidence of end organ failure
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