Chikungunya causes: Difference between revisions
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==Overview== | ==Overview== | ||
Chikungunya virus is an [[alphavirus]] with a positive sense single-stranded RNA genome of approximately 11.6kb. It is a member of the Semliki Forest Virus complex and is closely related to Ross River Virus, O’Nyong Nyong virus and [[Semliki Forest Virus]].<ref>{{cite journal|last=Powers|first=AM|coauthors=Brault, AC; Shirako, Y; Strauss, EG; Kang, W; Strauss, JH; Weaver, SC|title=Evolutionary relationships and systematics of the alphaviruses.|journal=Journal of Virology|date=Nov 2001|volume=75|issue=21|pages=10118–31|pmid=11581380|doi=10.1128/JVI.75.21.10118-10131.2001|pmc=114586}}</ref> In the United States it is classified as a Category C priority pathogen<ref>{{cite web|title=NIAID Category A, B, and C Priority Pathogens|url=http://www.niaid.nih.gov/topics/biodefenserelated/biodefense/pages/cata.aspx|accessdate=1 January 2014}}</ref> and work requires Biosafety Level III precautions.<ref>{{cite web|title=Biosafety in Microbiological and Biomedical Laboratories (BMBL) 5th Edition|url=http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5_sect_VIII_f.pdf|accessdate=1 January 2014}}</ref> | Chikungunya virus is an [[alphavirus]] with a positive sense single-stranded RNA genome of approximately 11.6kb. It is a member of the Semliki Forest Virus complex and is closely related to Ross River Virus, O’Nyong Nyong virus and [[Semliki Forest Virus]].<ref>{{cite journal|last=Powers|first=AM|coauthors=Brault, AC; Shirako, Y; Strauss, EG; Kang, W; Strauss, JH; Weaver, SC|title=Evolutionary relationships and systematics of the alphaviruses.|journal=Journal of Virology|date=Nov 2001|volume=75|issue=21|pages=10118–31|pmid=11581380|doi=10.1128/JVI.75.21.10118-10131.2001|pmc=114586}}</ref> In the United States it is classified as a Category C priority pathogen<ref>{{cite web|title=NIAID Category A, B, and C Priority Pathogens|url=http://www.niaid.nih.gov/topics/biodefenserelated/biodefense/pages/cata.aspx|accessdate=1 January 2014}}</ref> and work requires Biosafety Level III precautions.<ref>{{cite web|title=Biosafety in Microbiological and Biomedical Laboratories (BMBL) 5th Edition|url=http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5_sect_VIII_f.pdf|accessdate=1 January 2014}}</ref> | ||
Revision as of 17:06, 6 June 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]
Overview
Chikungunya virus is an alphavirus with a positive sense single-stranded RNA genome of approximately 11.6kb. It is a member of the Semliki Forest Virus complex and is closely related to Ross River Virus, O’Nyong Nyong virus and Semliki Forest Virus.[1] In the United States it is classified as a Category C priority pathogen[2] and work requires Biosafety Level III precautions.[3]
Human epithelial, endothelial, primary fibroblasts and monocyte-derived macrophages are permissive for chikungunya virus in vitro and viral replication is highly cytopathic but susceptible to type I and II interferon.[4] In vivo, chikungunya virus appears to replicate in fibroblasts, skeletal muscle progenitor cells and myofibers.[5][6]
References
- ↑ Powers, AM (Nov 2001). "Evolutionary relationships and systematics of the alphaviruses". Journal of Virology. 75 (21): 10118–31. doi:10.1128/JVI.75.21.10118-10131.2001. PMC 114586. PMID 11581380. Unknown parameter
|coauthors=ignored (help) - ↑ "NIAID Category A, B, and C Priority Pathogens". Retrieved 1 January 2014.
- ↑ "Biosafety in Microbiological and Biomedical Laboratories (BMBL) 5th Edition" (PDF). Retrieved 1 January 2014.
- ↑ Sourisseau, M (Jun 2007). "Characterization of reemerging chikungunya virus". PLoS Pathogens. 3 (6): e89. doi:10.1371/journal.ppat.0030089. PMC 1904475. PMID 17604450. Unknown parameter
|coauthors=ignored (help) - ↑ Schilte, C (Feb 15, 2010). "Type I IFN controls chikungunya virus via its action on nonhematopoietic cells". The Journal of experimental medicine. 207 (2): 429–42. doi:10.1084/jem.20090851. PMC 2822618. PMID 20123960. Unknown parameter
|coauthors=ignored (help) - ↑ Rohatgi, A (Dec 11, 2013). "Infection of myofibers contributes to the increased pathogenicity during infection with an epidemic strain of Chikungunya Virus". Journal of Virology. 88 (5): 2414–25. doi:10.1128/JVI.02716-13. PMID 24335291. Unknown parameter
|coauthors=ignored (help)