Sandbox/intraabdominal

Pediatric patients   ▸  Single agent   ▸  Combination Adults, mild-to-moderate severity   ▸  Single agent   ▸  Combination Adults, high risk or severity   ▸  Single agent   ▸  Combination

Single agent ▸ Ertapenem 3 months to 12 years 15 mg/kg IV q12h; >13 years 1 g IV q24h OR ▸ Meropenem 60 mg/kg/day IV q8h OR ▸ Imipenem/Cilastatin 60-100 mg/kg/day IV q4-6h OR ▸ Ticarcillin-Clavulanate 200-300 mg/kg/day IV q12h OR ▸ Piperacillin-Tazobactam 200-300 mg/kg/day IV q6-8h Combination ▸ Ceftriaxone 50-70 mg/kg/day IV q12-24h OR ▸ Cefotaxime 150-200 mg/kg/day IV q6-8h OR ▸ Cefepime 100 mg/kg/day IV q12h OR ▸ Ceftazidime 150 mg/kg/day IV q8h PLUS ▸ Metronidazole 30-40 mg/kg/day IV q8h OR ▸ Gentamicin 3-7.5 mg/kg/day IV q2-4h OR ▸ tobramycin 3-7.5 mg/kg/day IV q8-24h PLUS ▸ Metronidazole 30-40 mg/kg/day IV q8h OR ▸ Clindamycin 20-40 mg/kg/day IV q6-8h WITH OR WITHOUT ▸ Ampicillin 200 mg/kg/day IV q8-24h Single agent ▸ Cefoxitin 2 g IV q6h OR ▸ Ertapenem 1 g IV q24h OR ▸ Moxifloxacin 400 mg IV q24h OR ▸ Tigecycline 100 mg initial dose, then 50 mg IV q12h OR ▸ Ticarcillin-Clavulanic acid 200 mg/kg/day IV q6h Combination ▸ Cefazolin 1-2 g IV q8h OR ▸ Cefuroxime 1.5 g IV q8h OR ▸ Ceftriaxone 1-2 g IV q12-24h OR ▸ Cefotaxime 1-2 g IV q6-8h OR ▸ Ciprofloxacin 400 mg IV q12h OR ▸ Levofloxacin 750 mg IV q24h PLUS ▸ Metronidazole 500 mg IV q8-12h or 1.5 g q24h Sequential therapy First 7 days ▸ Lansoprazole 30 mg q12h OR ▸ Omeprazole 20 mg q12h OR ▸ Esomeprazole 40 mg q24h OR ▸ Rabeprazole 20 mg q12h PLUS ▸ Amoxicillin 1 g q12h Next 7 days ▸ PPI standard dose PLUS ▸ Amoxicillin 1 g q12h PLUS ▸ Clarithromycin 500 mg q12h PLUS ▸ Metronidazol 500 mg q12h Third line treatment ▸ Rifabutin 150 mg q2h PLUS ▸ Amoxicillin 1 g IV q12h PLUS ▸ Ciprofloxacin 500 mg/kg IV q12h