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| ==Overview== | | ==Overview== |
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| ==Future Therapies==
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| {| style="border: 0px; font-size: 85%; margin: 3px;" align=center
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| ! style="background: #4479BA; width: 120px;" | {{fontcolor|#FFF|}}
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| ! style="background: #4479BA; width: 160px;" | {{fontcolor|#FFF|Chloroquine}}
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| ! style="background: #4479BA; width: 160px;" | {{fontcolor|#FFF|Ribavirin}}
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| ! style="background: #4479BA; width: 160px;" | {{fontcolor|#FFF|6-Azauridine}}
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| ! style="background: #4479BA; width: 160px;" | {{fontcolor|#FFF|Arbidol}}
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| ! style="background: #4479BA; width: 160px;" | {{fontcolor|#FFF|Harringtonine}}
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| | style="padding: 5px 5px; background: #DCDCDC;" | Assay type
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| | style="padding: 5px 5px; background: #F5F5F5;" |In vitro (vero cells)
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| | style="padding: 5px 5px; background: #F5F5F5;" |Human
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| | style="padding: 5px 5px; background: #F5F5F5;" |In vitro (vero cells)
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| | style="padding: 5px 5px; background: #F5F5F5;" |In vitro (vero and primary human fibroblast cells)
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| | style="padding: 5px 5px; background: #F5F5F5;" |In vitro (BHK21 cells)
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| | style="padding: 5px 5px; background: #DCDCDC;" | Hypothesized target
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| | style="padding: 5px 5px; background: #F5F5F5;" | Disrupted endosome-mediated CHIKV internalization, possibly through the prevention of endosomal acidification.
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| | style="padding: 5px 5px; background: #F5F5F5;" |Can interact with the intracellular viral RNA production.
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| | style="padding: 5px 5px; background: #F5F5F5;" |Inhibition of orotidine monophosphate decarboxylase, an enzyme involved in the de novo biosynthesis of pyrimidine, cytidine, and thymidine.
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| | style="padding: 5px 5px; background: #F5F5F5;" |Inhibition of virus mediated fusion and blocking of the viral entry into the target cells through inhibition of glycoprotein conformational changes that are essential for the fusion process.
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| | style="padding: 5px 5px; background: #F5F5F5;" |Affects CHIKV RNA production inside the infected cell as well as viral protein expression such as the nsP3 and the E2 proteins.
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| | style="padding: 5px 5px; background: #DCDCDC;" | Advantages
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| | style="padding: 5px 5px; background: #DCDCDC;" | Disadvantages
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| | style="padding: 5px 5px; background: #DCDCDC;" | References
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| | style="padding: 5px 5px; background: #FFF;" colspan="6"| <SMALL>Table adapted from </SMALL>
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| |}
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| ==References== | | ==References== |