Vitiligo other diagnostic studies: Difference between revisions
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==Other Diagnosis Studies== | ==Other Diagnosis Studies== | ||
===Biopsy=== | ===Biopsy=== | ||
Frequently not required, since the diagnosis is often suggested by the history and characteristics of the lesions. However, an [[electron microscopy]] study of the skin lesions will show the previously mentioned microscopical changes, thereby confirming:<ref>{{cite book | last = Rook | first = Arthur | title = Rook's textbook of dermatology | publisher = Blackwell Science | location = Malden, Mass | year = 2004 | isbn = 0-632-06429-3 }}</ref> | Frequently not required, since the diagnosis is often suggested by the history and characteristics of the lesions. However, an [[electron microscopy]] study of the skin lesions will show the previously mentioned microscopical changes, thereby confirming:<ref>{{cite book | last = Rook | first = Arthur | title = Rook's textbook of dermatology | publisher = Blackwell Science | location = Malden, Mass | year = 2004 | isbn = 0-632-06429-3 }}</ref><ref name="pmid5448375">{{cite journal| author=Dawber RP| title=Clinical associations of vitiligo. | journal=Postgrad Med J | year= 1970 | volume= 46 | issue= 535 | pages= 276-7 | pmid=5448375 | doi= | pmc=PMC2467025 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=5448375 }} </ref><ref name="BirbeckBreathnach1961">{{cite journal|last1=Birbeck|first1=Michael S|last2=Breathnach|first2=Aodán S|last3=Everall|first3=John D|title=An Electron Microscope Study of Basal Melanocytes and High-Level Clear Cells (Langerhans Cells) in Vitiligo1|journal=The Journal of Investigative Dermatology|volume=37|issue=1|year=1961|pages=51–64|issn=0022-202X|doi=10.1038/jid.1961.80}}</ref> | ||
*Melanocyte loss. | *Melanocyte loss. | ||
*Melanocyte degeneration on the margins of the lesions. | *Melanocyte degeneration on the margins of the lesions. | ||
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*Occasional dermal hypercellularity may be found. | *Occasional dermal hypercellularity may be found. | ||
*In inflammatory vitiligo, the study of the cells from the erythematous margins will show the lymphocitic infiltrates. | *In inflammatory vitiligo, the study of the cells from the erythematous margins will show the lymphocitic infiltrates. | ||
Electron microscopy studies [9,26,27] confirm the loss of melanocytes, which appear to be replaced by Langerhans’ cells. In the epidermis of areas around the margins of vitiligo are abnormalities of keratinocytes [9] as well as degenerating melanocytes. There is increased cellularity of the dermis and occasional colloid amyloid bodies are found. In inflammatory vitiligo, where there is a raised erythematous border, there is an infiltrate of lymphocytes and histiocytes. | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
The cellular mechanism beneath the vitiligo lesion is the destruction of melanocytes. Therefore, on an histological study, it will be noted the absence of melanocytes on the region of the lesion and possibly lymphocytic infiltrates on its periphery, consistent with the destruction of melanocytes by the immune system.
Other Diagnosis Studies
Biopsy
Frequently not required, since the diagnosis is often suggested by the history and characteristics of the lesions. However, an electron microscopy study of the skin lesions will show the previously mentioned microscopical changes, thereby confirming:[1][2][3]
- Melanocyte loss.
- Melanocyte degeneration on the margins of the lesions.
- Keratinocyte abnormalities.
- Occasional dermal hypercellularity may be found.
- In inflammatory vitiligo, the study of the cells from the erythematous margins will show the lymphocitic infiltrates.
Electron microscopy studies [9,26,27] confirm the loss of melanocytes, which appear to be replaced by Langerhans’ cells. In the epidermis of areas around the margins of vitiligo are abnormalities of keratinocytes [9] as well as degenerating melanocytes. There is increased cellularity of the dermis and occasional colloid amyloid bodies are found. In inflammatory vitiligo, where there is a raised erythematous border, there is an infiltrate of lymphocytes and histiocytes.
References
- ↑ Rook, Arthur (2004). Rook's textbook of dermatology. Malden, Mass: Blackwell Science. ISBN 0-632-06429-3.
- ↑ Dawber RP (1970). "Clinical associations of vitiligo". Postgrad Med J. 46 (535): 276–7. PMC 2467025. PMID 5448375.
- ↑ Birbeck, Michael S; Breathnach, Aodán S; Everall, John D (1961). "An Electron Microscope Study of Basal Melanocytes and High-Level Clear Cells (Langerhans Cells) in Vitiligo1". The Journal of Investigative Dermatology. 37 (1): 51–64. doi:10.1038/jid.1961.80. ISSN 0022-202X.