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__NOTOC__ | __NOTOC__ | ||
{{ | {{Rosuvastatin}} | ||
{{CMG}}; {{AE | {{CMG}}; {{AE}} | ||
'''''For patient information about | '''''For patient information about Rosuvastatin, click [[Rosuvastatin (patient information)|here]].''''' | ||
{{SB}} | {{SB}} CRESTOR<sup>®</sup> | ||
==Overview== | ==Overview== | ||
''' | '''Rosuvastatin''' is a member of the [[medication|drug]] class of [[statin]]s, used to treat [[hypercholesterolemia]] and related conditions, and to prevent [[cardiovascular disease]]. It is currently being marketed by the [[pharmaceutical company]] [[AstraZeneca]] as '''Crestor'''. | ||
==Category== | |||
Statins,Diols,Carboxylic acids,Sulfonamides,Pyrimidines,Organofluorides,Cardiovasular drugs. | |||
==FDA Package Insert== | ==FDA Package Insert== | ||
''' [[Rosuvastatin indications and usage|Indications and Usage]]''' | |||
''' [[ | '''| [[Rosuvastatin dosage and administration|Dosage and Administration]]''' | ||
'''| [[ | '''| [[Rosuvastatin dosage forms and strengths|Dosage Forms and Strengths]]''' | ||
'''| [[ | '''| [[Rosuvastatin contraindications|Contraindications]]''' | ||
'''| [[ | '''| [[Rosuvastatin warnings and precautions|Warnings and Precautions]]''' | ||
'''| [[ | '''| [[Rosuvastatin adverse reactions|Adverse Reactions]]''' | ||
'''| [[ | '''| [[Rosuvastatin drug interactions|Drug Interactions]]''' | ||
'''| [[ | '''| [[Rosuvastatin use in specific populations|Use in Specific Populations]]''' | ||
'''| [[ | '''| [[Rosuvastatin overdosage|Overdosage]]''' | ||
'''| [[ | '''| [[Rosuvastatin description|Description]]''' | ||
'''| [[ | '''| [[Rosuvastatin clinical pharmacology|Clinical Pharmacology]]''' | ||
'''| [[ | '''| [[Rosuvastatin nonclinical toxicology|Nonclinical Toxicology]]''' | ||
'''| [[ | '''| [[Rosuvastatin clinical studies|Clinical Studies]]''' | ||
'''| [[ | '''| [[Rosuvastatin how supplied storage and handling|How Supplied/Storage and Handling]]''' | ||
'''| [[Rosuvastatin patient counseling information|Patient Counseling Information]]''' | |||
'''| [[Rosuvastatin labels and packages|Labels and Packages]]''' | |||
==Mechanism of Action== | ==Mechanism of Action== | ||
CRESTOR is a selective and competitive inhibitor of [[HMG-CoA]] reductase, the rate-limiting enzyme that converts 3‑hydroxy‑3‑methylglutaryl coenzyme A to mevalonate, a precursor of [[cholesterol]]. In vivo studies in animals, and in vitro studies in cultured animal and human cells have shown rosuvastatin to have a high uptake into, and selectivity for, action in the liver, the target organ for [[cholesterol]] lowering. In in vivo and in vitro studies, rosuvastatin produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell-surface to enhance uptake and catabolism of LDL. Second, rosuvastatin inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles. | |||
==Interaction with Alcohol== | |||
CRESTOR should be used with caution in patients who consume substantial quantities of alcohol and/or have a history of chronic liver disease.Chronic alcohol liver disease is known to increase rosuvastatin exposure. | |||
==References== | ==References== | ||
{{Reflist|2}} | |||
{{ | {{Statins}} | ||
[[Category: | [[Category:Statins]] | ||
[[Category: | [[Category:AstraZeneca]] | ||
[[Category: | [[Category:Carboxylic acids]] | ||
[[Category: | [[Category:Sulfonamides]] | ||
[[Category:Pyrimidines]] | |||
[[Category:Organofluorides]] | |||
[[Category:Cardiovasular drugs]] | |||
[[Category:Drugs]] |
Revision as of 14:02, 30 June 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
For patient information about Rosuvastatin, click here.
Synonyms / Brand Names: CRESTOR®
Overview
Rosuvastatin is a member of the drug class of statins, used to treat hypercholesterolemia and related conditions, and to prevent cardiovascular disease. It is currently being marketed by the pharmaceutical company AstraZeneca as Crestor.
Category
Statins,Diols,Carboxylic acids,Sulfonamides,Pyrimidines,Organofluorides,Cardiovasular drugs.
FDA Package Insert
Indications and Usage | Dosage and Administration | Dosage Forms and Strengths | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Use in Specific Populations | Overdosage | Description | Clinical Pharmacology | Nonclinical Toxicology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages
Mechanism of Action
CRESTOR is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3‑hydroxy‑3‑methylglutaryl coenzyme A to mevalonate, a precursor of cholesterol. In vivo studies in animals, and in vitro studies in cultured animal and human cells have shown rosuvastatin to have a high uptake into, and selectivity for, action in the liver, the target organ for cholesterol lowering. In in vivo and in vitro studies, rosuvastatin produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell-surface to enhance uptake and catabolism of LDL. Second, rosuvastatin inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.
Interaction with Alcohol
CRESTOR should be used with caution in patients who consume substantial quantities of alcohol and/or have a history of chronic liver disease.Chronic alcohol liver disease is known to increase rosuvastatin exposure.