Cisatracurium: Difference between revisions
Gerald Chi (talk | contribs) mNo edit summary |
Gerald Chi (talk | contribs) mNo edit summary |
||
| Line 25: | Line 25: | ||
| routes_of_administration = IV only | | routes_of_administration = IV only | ||
}} | }} | ||
__NOTOC__ | |||
{{SI}} | |||
{{CMG}} | |||
==Overview== | |||
'''Cisatracurium''' (usually as '''cisatracurium besilate''', trade name '''Nimbex''') is a [[neuromuscular-blocking drug]]. It is one of the ten [[isomers]] of [[atracurium]]. Its active [[metabolites]] contain less [[laudanosine]] which cause [[hypotension]], central nervous system excitement, and seizures than that of atracurium. It is considered an intermediate-acting agent in terms of duration of action. | '''Cisatracurium''' (usually as '''cisatracurium besilate''', trade name '''Nimbex''') is a [[neuromuscular-blocking drug]]. It is one of the ten [[isomers]] of [[atracurium]]. Its active [[metabolites]] contain less [[laudanosine]] which cause [[hypotension]], central nervous system excitement, and seizures than that of atracurium. It is considered an intermediate-acting agent in terms of duration of action. | ||
| Line 37: | Line 43: | ||
* {{cite journal | author = Melloni C, Devivo P, Launo C, Mastronardi P, Novelli G, Romano E | title = Cisatracurium versus vecuronium: a comparative, double blind, randomized, multicenter study in adult patients under propofol/fentanyl/N2O anesthesia. | journal = Minerva Anestesiol | volume = 72 | issue = 5 | pages = 299-308 | year = 2006 | id = PMID 16675938}} | * {{cite journal | author = Melloni C, Devivo P, Launo C, Mastronardi P, Novelli G, Romano E | title = Cisatracurium versus vecuronium: a comparative, double blind, randomized, multicenter study in adult patients under propofol/fentanyl/N2O anesthesia. | journal = Minerva Anestesiol | volume = 72 | issue = 5 | pages = 299-308 | year = 2006 | id = PMID 16675938}} | ||
* {{cite journal | author = Serra C, Oliveira A | title = Cisatracurium: myographical and electrophysiological studies in the isolated rat muscle. | journal = Fundam Clin Pharmacol | volume = 20 | issue = 3 | pages = 291-8 | year = 2006 | id = PMID 16671964}} | * {{cite journal | author = Serra C, Oliveira A | title = Cisatracurium: myographical and electrophysiological studies in the isolated rat muscle. | journal = Fundam Clin Pharmacol | volume = 20 | issue = 3 | pages = 291-8 | year = 2006 | id = PMID 16671964}} | ||
[[Category:Muscle relaxants]] | [[Category:Muscle relaxants]] | ||
[[Category:Quaternary ammonium compounds]] | [[Category:Quaternary ammonium compounds]] | ||
Revision as of 22:05, 1 July 2014
| File:Cisatracurium.svg | |
| Clinical data | |
|---|---|
| Pregnancy category |
|
| Routes of administration | IV only |
| ATC code | |
| Pharmacokinetic data | |
| Bioavailability | N/A - IV use only |
| Protein binding | Unknown due to rapid degradation |
| Metabolism | 80% Hoffman elmination/ Hepatic |
| Elimination half-life | 20-29 minutes |
| Excretion | 10-15% unchanged |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C53H72N2O12+2 |
| Molar mass | 929.145 g/mol |
|
WikiDoc Resources for Cisatracurium |
|
Articles |
|---|
|
Most recent articles on Cisatracurium Most cited articles on Cisatracurium |
|
Media |
|
Powerpoint slides on Cisatracurium |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Cisatracurium at Clinical Trials.gov Trial results on Cisatracurium Clinical Trials on Cisatracurium at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Cisatracurium NICE Guidance on Cisatracurium
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Cisatracurium Discussion groups on Cisatracurium Patient Handouts on Cisatracurium Directions to Hospitals Treating Cisatracurium Risk calculators and risk factors for Cisatracurium
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Cisatracurium |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Cisatracurium (usually as cisatracurium besilate, trade name Nimbex) is a neuromuscular-blocking drug. It is one of the ten isomers of atracurium. Its active metabolites contain less laudanosine which cause hypotension, central nervous system excitement, and seizures than that of atracurium. It is considered an intermediate-acting agent in terms of duration of action.
Structure
It is a benzyl-isoquinolinium agent in the quaternary ammonium compound family.
Metabolism
80% is metabolized to laudanosine via Hoffman Elimination (which is dependent on the pH and the temperature of the plasma) and 20% is metabolized hepatically or excreted renally. Since Hoffman elimination is organ-independent, the use of cisatracurium may pose less risk in patients with liver or renal disease than other neuromuscular blockers. 10-15% of the dose is excreted unchanged in the urine.
External links
- Esmaoglu A, Akin A, Mizrak A, Turk Y, Boyaci A (2006). "Addition of cisatracurium to lidocaine for intravenous regional anesthesia". J Clin Anesth. 18 (3): 194–7. PMID 16731321.
- Melloni C, Devivo P, Launo C, Mastronardi P, Novelli G, Romano E (2006). "Cisatracurium versus vecuronium: a comparative, double blind, randomized, multicenter study in adult patients under propofol/fentanyl/N2O anesthesia". Minerva Anestesiol. 72 (5): 299–308. PMID 16675938.
- Serra C, Oliveira A (2006). "Cisatracurium: myographical and electrophysiological studies in the isolated rat muscle". Fundam Clin Pharmacol. 20 (3): 291–8. PMID 16671964.
- Pages with script errors
- Pages with broken file links
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- CS1 maint: Multiple names: authors list
- Muscle relaxants
- Quaternary ammonium compounds