Leprosy other diagnostic studies: Difference between revisions
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===Smear test=== | ===Smear test=== | ||
May be obtained from any [[skin lesion]], from the [[nasal mucosa]] and/or the [[ear lobe]]. This test has a [[sensitivity]] of 50% and a [[specificity]] of 100%. After collection of the | May be obtained from any [[skin lesion]], from the [[nasal mucosa]] and/or the [[ear lobe]]. This test has a [[sensitivity]] of 50% and a [[specificity]] of 100%. After collection of the specimen, in order to visualize the [[bacteria]], the ''Ziehl-Neelsen stain'' should be used.<ref name="EichelmannGonzález González2013">{{cite journal|last1=Eichelmann|first1=K.|last2=González González|first2=S.E.|last3=Salas-Alanis|first3=J.C.|last4=Ocampo-Candiani|first4=J.|title=Leprosy. An Update: Definition, Pathogenesis, Classification, Diagnosis, and Treatment|journal=Actas Dermo-Sifiliográficas (English Edition)|volume=104|issue=7|year=2013|pages=554–563|issn=15782190|doi=10.1016/j.adengl.2012.03.028}}</ref><ref name="pmid7570870">{{cite journal| author=Hatta M, van Beers SM, Madjid B, Djumadi A, de Wit MY, Klatser PR| title=Distribution and persistence of Mycobacterium leprae nasal carriage among a population in which leprosy is endemic in Indonesia. | journal=Trans R Soc Trop Med Hyg | year= 1995 | volume= 89 | issue= 4 | pages= 381-5 | pmid=7570870 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7570870 }} </ref><ref name="pmid20966523">{{cite journal| author=Aggarwal A, Pandey A| title=Inverse sampling to study disease burden of leprosy. | journal=Indian J Med Res | year= 2010 | volume= 132 | issue= | pages= 438-41 | pmid=20966523 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20966523 }} </ref><ref name="pmid9503866">{{cite journal| author=Ramaprasad P, Fernando A, Madhale S, Rao JR, Edward VK, Samson PD et al.| title=Transmission and protection in leprosy: indications of the role of mucosal immunity. | journal=Lepr Rev | year= 1997 | volume= 68 | issue= 4 | pages= 301-15 | pmid=9503866 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9503866 }} </ref> | ||
===Skin Biopsy=== | ===Skin Biopsy=== | ||
Revision as of 05:47, 6 July 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Although there are no laboratory studies to help in the diagnosis of leprosy, other studies
Other Diagnostic Studies
Smear test
May be obtained from any skin lesion, from the nasal mucosa and/or the ear lobe. This test has a sensitivity of 50% and a specificity of 100%. After collection of the specimen, in order to visualize the bacteria, the Ziehl-Neelsen stain should be used.[1][2][3][4]
Skin Biopsy
Lepromin Test
Serology
Polymerase Chain Reaction
References
- ↑ Eichelmann, K.; González González, S.E.; Salas-Alanis, J.C.; Ocampo-Candiani, J. (2013). "Leprosy. An Update: Definition, Pathogenesis, Classification, Diagnosis, and Treatment". Actas Dermo-Sifiliográficas (English Edition). 104 (7): 554–563. doi:10.1016/j.adengl.2012.03.028. ISSN 1578-2190.
- ↑ Hatta M, van Beers SM, Madjid B, Djumadi A, de Wit MY, Klatser PR (1995). "Distribution and persistence of Mycobacterium leprae nasal carriage among a population in which leprosy is endemic in Indonesia". Trans R Soc Trop Med Hyg. 89 (4): 381–5. PMID 7570870.
- ↑ Aggarwal A, Pandey A (2010). "Inverse sampling to study disease burden of leprosy". Indian J Med Res. 132: 438–41. PMID 20966523.
- ↑ Ramaprasad P, Fernando A, Madhale S, Rao JR, Edward VK, Samson PD; et al. (1997). "Transmission and protection in leprosy: indications of the role of mucosal immunity". Lepr Rev. 68 (4): 301–15. PMID 9503866.