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Revision as of 12:51, 11 July 2014

Bisoprolol
ZEBETA^® FDA Package Insert
Indications and Usage
Dosage and Administration
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
Clinical Studies
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
Clinical Trials on Bisoprolol
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]

For patient information about Bisoprolol, click here.

Synonyms / Brand Names: ZEBETA^®

Overview

Bisoprolol is a drug belonging to the group of beta blockers, a class of drugs used primarily in cardiovascular diseases. More specifically, it is a selective type β1 adrenergic receptor blocker ^[1].

FDA Package Insert

ZEBETA (bisoprolol fumarate) tablet

Mechanism of Action

The mechanism of action of its antihypertensive effects has not been completely established. Factors which may be involved include:

Decreased cardiac output,
Inhibition of renin release by the kidneys,
Diminution of tonic sympathetic outflow from the vasomotor centers in the brain.

References

↑ FASS (Swedish official drug catalog) (labeling as "Selektiv beta1-blockerare" = selective beta1-blocker)

[1] FASS (Swedish official drug catalog) (labeling as "Selektiv beta1-blockerare" = selective beta1-blocker)

[1]

@@ Line 1: / Line 1: @@
 __NOTOC__
+{{Bisoprolol}}
-{{Betaxolol}}
 {{CMG}}; {{AE}} {{SS}}
-'''''For patient information about Betaxolol, click [[Betaxolol (patient information)|here]]'''''
+'''''For patient information about Bisoprolol, click [[Bisoprolol (patient information)|here]].'''''
-{{SB}} BETOPTIC<sup>®</sup>
+{{SB}} ZEBETA<sup>®</sup>
 ==Overview==
-'''Betaxolol''' (trade names '''Betoptic''', '''Betoptic S''', '''Lokren''', '''Kerlone''') is a selective [[beta blocker|beta<sub>1</sub> receptor blocker]] used in the treatment of [[hypertension]] and [[glaucoma]]. Being selective for beta<sub>1</sub> receptors, it typically has fewer systemic[[adverse drug reaction|side effect]]s than non-selective beta-blockers, for example, not causing [[bronchospasm]] (mediated by beta<sub>2</sub>receptors) as [[timolol]] may.  Betaxolol also shows greater affininty for beta<sub>1</sub> receptors than [[metoprolol]]. In addition to its effect on the heart, betaxolol reduces the pressure within the eye ([[intraocular pressure]]). This effect is thought to be caused by reducing the production of the liquid (which is called the [[aqueous humor]]) within the eye. The precise mechanism of this effect is not known. The reduction in intraocular pressure reduces the risk of damage to the [[optic nerve]] and loss of vision in patients with elevated intraocular pressure due to [[glaucoma]].
-Betaxolol was approved by the U.S. [[Food and Drug Administration]] (FDA) for ocular use as a 0.5% solution ('''Betoptic''') in 1985 and as a 0.25% solution ('''Betoptic S''') in 1989.
+'''Bisoprolol''' is a drug belonging to the group of [[beta blocker]]s, a class of drugs used primarily in [[cardiovascular disease]]s. More specifically, it is a selective type β1 [[adrenergic receptor]] blocker <ref>[http://www.fass.se/LIF/produktfakta/artikel_produkt.jsp?NplID=20040326000029&DocTypeID=7&UserTypeID=2 FASS (Swedish official drug catalog) (labeling as "Selektiv beta1-blockerare" = selective beta1-blocker)]</ref>.
 ==Category==
-Cardiovascular Drugs:Beta blockers
+Beta blockers
 ==FDA Package Insert==
-'''| [[Betaxolol indications and usage|Indications and Usage]]'''
+====ZEBETA (bisoprolol fumarate) tablet====
-'''| [[Betaxolol dosage and administration|Dosage and Administration]]'''
-'''| [[Betaxolol contraindications|Contraindications]]'''
+'''  [[Bisoprolol indications and usage|Indications and Usage]]'''
-'''| [[Betaxolol warnings and precautions|Warnings and Precautions]]'''
+'''| [[Bisoprolol dosage and administration|Dosage and Administration]]'''
-'''| [[Betaxolol adverse reactions|Adverse Reactions]]'''
+'''| [[Bisoprolol contraindications|Contraindications]]'''
-'''| [[Betaxolol drug interactions|Drug Interactions]]'''
+'''| [[Bisoprolol warnings and precautions|Warnings and Precautions]]'''
-'''| [[Betaxolol use in specific populations|Use in Specific Populations]]'''
+'''| [[Bisoprolol adverse reactions|Adverse Reactions]]'''
-'''| [[Betaxolol overdosage|Overdosage]]'''
+'''| [[Bisoprolol drug interactions|Drug Interactions]]'''
-'''| [[Betaxolol description|Description]]'''
+'''| [[Bisoprolol use in specific populations|Use in Specific Populations]]'''
-'''| [[Betaxolol clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[Bisoprolol overdosage|Overdosage]]'''
-'''| [[Betaxolol nonclinical toxicology|Nonclinical Toxicology]]'''
+'''| [[Bisoprolol description|Description]]'''
-'''| [[Betaxolol clinical studies|Clinical Studies]]'''
+'''| [[Bisoprolol clinical pharmacology|Clinical Pharmacology]]'''
-'''| [[Betaxolol how supplied storage and handling|How Supplied/Storage and Handling]]'''
+'''| [[Bisoprolol nonclinical toxicology|Nonclinical Toxicology]]'''
+'''| [[Bisoprolol clinical studies|Clinical Studies]]'''
+'''| [[Bisoprolol how supplied storage and handling|How Supplied/Storage and Handling]]'''
+'''| [[Bisoprolol patient counseling information|Patient Counseling Information]]'''
+'''| [[Bisoprolol labels and packages|Labels and Packages]]'''
 ==Mechanism of Action==
-The mechanism of action has not been definitively established. Possible factors that may be involved include: (1) decreased heart rate, (2) decreased myocardial contractility, (3) diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers, (4) suppression of renin activity and (5) vasodilation and decreased peripheral vascular resistance.
+The mechanism of action of its antihypertensive effects has not been completely established. Factors which may be involved include:
+*Decreased cardiac output,
+*Inhibition of renin release by the kidneys,
+*Diminution of tonic sympathetic outflow from the vasomotor centers in the brain.
 ==References==
 {{Reflist|2}}
 [[Category:Beta blockers]]
 [[Category:Cardiovascular Drugs]]
 [[Category:Drugs]]
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