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{{DrugProjectFormSinglePage
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Gerald Chi
{{Lidocaine}}


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{{CMG}}; {{AE}} {{AZ}}


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'''''For patient information about Lidocaine Transdermal Patch, click <u>[[Lidocaine (patient information)|here]]'''''</u>.


'''''For patient information about Lidocaine Viscous (lye' doe kane), click <u>[[Lidocaine (patient information)|here]]'''''</u>.


{{SB}} XYLOCAINE


|aOrAn=
==Overview==
'''Lidocaine''' '''xylocaine''', or '''lignocaine''' (former [[British Approved Name|BAN]] is a common [[local anesthetic]] and [[antiarrhythmic agent|antiarrhythmic]] drug. Lidocaine is used [[topical]]ly to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery.


a
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Anesthetic and Antiarrythmic


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'''| [[Lidocaine indications and usage|Indications and Usage]]'''
'''| [[Lidocaine dosage and administration|Dosage and Administration]]'''
'''| [[Lidocaine contraindications|Contraindications]]'''
'''| [[Lidocaine warnings|Warnings and Precautions]]'''
'''| [[Lidocaine adverse reactions|Adverse Reactions]]'''
'''| [[Lidocaine drug interactions|Drug Interactions]]'''
'''| [[Lidocaine use in specific populations|Use in Specific Populations]]'''
'''| [[Lidocaine overdosage|Overdosage]]'''
'''| [[Lidocaine description|Description]]'''
'''| [[Lidocaine clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Lidocaine nonclinical toxicology|Nonclinical Toxicology]]'''
'''| [[Lidocaine clinical studies|Clinical Studies]]'''
'''| [[Lidocaine how supplied storage and handling|How Supplied/Storage and Handling]]'''
'''| [[Lidocaine patient counseling information|Patient Counseling Information]]'''
'''| [[Lidocaine labels and packages|Labels and Packages]]'''


==Mechanism of Action==
Lidocaine alters signal conduction in [[neuron]]s by blocking the fast [[sodium channel|voltage gated sodium (Na<sup>+</sup>) channels]] in the neuronal cell membrane that are responsible for signal propagation.<ref name="novartis">{{cite journal |doi=10.1002/0470846682.ch14 |chapter=Molecular Mechanisms of Gating and Drug Block of Sodium Channels |title=Sodium Channels and Neuronal Hyperexcitability |series=Novartis Foundation Symposia |year=2001 |last1=Carterall |first1=William A. |isbn=9780470846681 |volume=241 |pages=206}}</ref> With sufficient blockage the membrane of the postsynaptic neuron will not depolarize and will thus fail to transmit an [[action potential]]. This creates the [[anaesthetic]] effect by not merely preventing pain signals from propagating to the brain but by stopping them before they begin. Careful titration allows for a high degree of selectivity in the blockage of sensory neurons, whereas higher concentrations will also affect other modalities of neuron signaling.


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==References==


{{Reflist|2}}


 
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Revision as of 19:58, 10 July 2014


Lidocaine
XYLOCAINE® FDA Package Insert
Indications and Usage
Dosage and Administration
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
How Supplied/Storage and Handling
Labels and Packages
Clinical Trials on Lidocaine
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]

For patient information about Lidocaine Transdermal Patch, click here.

For patient information about Lidocaine Viscous (lye' doe kane), click here.

Synonyms / Brand Names: XYLOCAINE

Overview

Lidocaine xylocaine, or lignocaine (former BAN is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery.

Category

Anesthetic and Antiarrythmic

FDA Package Insert[1]

| Indications and Usage | Dosage and Administration | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Use in Specific Populations | Overdosage | Description | Clinical Pharmacology | Nonclinical Toxicology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages

Mechanism of Action

Lidocaine alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation.[2] With sufficient blockage the membrane of the postsynaptic neuron will not depolarize and will thus fail to transmit an action potential. This creates the anaesthetic effect by not merely preventing pain signals from propagating to the brain but by stopping them before they begin. Careful titration allows for a high degree of selectivity in the blockage of sensory neurons, whereas higher concentrations will also affect other modalities of neuron signaling.

References

  1. ↑ "XYLOCAINE (LIDOCAINE HYDROCHLORIDE) INJECTION [ASTRAZENECA LP]".
  2. ↑ Carterall, William A. (2001). "Sodium Channels and Neuronal Hyperexcitability". Novartis Foundation Symposia. 241: 206. doi:10.1002/0470846682.ch14. ISBN 9780470846681. |chapter= ignored (help)
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