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| | | #REDIRECT [[BICATULAMIDE]] |
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| '''''For patient information, click [[Bicalutamide (patient information)|here.]]''<br>
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| {{drugbox
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| | IUPAC_name = ''N''-[4-cyano-3-(trifluoromethyl)phenyl]- 3-(4-fluorophenyl)sulfonyl-2- hydroxy-2-methyl- propanamide
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| | image = Bicalutamide.svg
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| | image2 = bicalutamide.gif
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| | width2 = 150
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| | CAS_number = 90357-06-5
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| | ATC_prefix = L02
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| | ATC_suffix = BB03
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| | ATC_supplemental =
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| | PubChem = 56069
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| | DrugBank = APRD00042
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| | C = 18 | H = 14 | F = 4 | N = 2 | O = 4 | S = 1
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| | molecular_weight = 430.374 g/mol
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| | bioavailability = well absorbed
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| | protein_bound = 96%
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| | metabolism = [[Liver|hepatic]]
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| | elimination_half-life = 5.8 days
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| | pregnancy_US = X
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| | pregnancy_category =
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| | legal_status = Rx-only
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| | routes_of_administration = Oral
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| }}
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| <!-- FAIR USE of bicalutamide.gif: see image description page at http://en.wikipedia.org/wiki/Image:bicalutamide.gif for rationale -->
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| '''Bicalutamide''' (marketed as '''Casodex'''®, '''Cosudex'''®, '''Calutide'''®, '''Kalumid'''®) is an oral non-steroidal [[anti-androgen]] for [[prostate cancer]]. It was first launched in 1995 as a combination treatment (with surgical or medical [[orchiectomy|castration]]) for advanced prostate cancer and subsequently launched as monotherapy for the treatment of earlier stages of the disease.
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| It is marketed by [[AstraZeneca]] with the brand names '''Casodex''' and '''Cosudex'''.
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| Bicalutamide is recommended 50 mg once daily in combination with an [[LHRH analogue]] or surgical castration.
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| == Description ==
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| Bicalutamide is an oral non-steroidal anti-androgen with the empirical formula C<sub>18</sub>H<sub>14</sub>N<sub>2</sub>O<sub>4</sub>F<sub>4</sub>S and is an off-white powder that is practically insoluble in water.
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| == Indications and use ==
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| For the treatment of stage D2 metastatic prostate cancer in combination with a luteinizing hormone-releasing hormone analogue or as a monotherapy. Has been used in clinical trials for ovarian cancer.
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| == Contraindications and precautions ==
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| Bicalutamide is contra-indicated in females and children and must not be given to any patient who has shown a hypersensitivity reaction to its use.
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| == Adverse reactions ==
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| [[Adverse drug reaction|Adverse reaction]]s include reproductive system and breast disorders, breast tenderness, [[gynaecomastia]], hot flushes, gastrointestinal disorders, diarrhoea, nausea, hepatic changes (elevated levels of [[transaminase]]s, jaundice), [[asthenia]] and pruritus.
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| ==Pill Images==
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| {{TempDrugImages}}
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| {{PillImage|fileName=CASODEX_NDC_03100705.jpg|drugName=CASODEX|NDC=03100705|drugAuthor=AstraZeneca Pharmaceuticals LP|ingredients=BICALUTAMIDE[BICALUTAMIDE]|pillImprint=CDX50|dosageValue=50|dosageUnit=mg|pillColor=White|pillShape=Round|pillSize=7|pillScore=1}}
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| {{PillImage|fileName=Bicalutamide_NDC_03787017.jpg|drugName=Bicalutamide|NDC=03787017|drugAuthor=Mylan Pharmaceuticals Inc|ingredients=Bicalutamide[Bicalutamide]|pillImprint=M;C17|dosageValue=50|dosageUnit=mg|pillColor=White|pillShape=Round|pillSize=6|pillScore=1}}
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| {{PillImage|fileName=Bicalutamide_NDC_519910560.jpg|drugName=Bicalutamide|NDC=519910560|drugAuthor=Breckenridge Pharmaceutical, Inc.|ingredients=Bicalutamide[Bicalutamide]|pillImprint=BCM;50|dosageValue=50|dosageUnit=mg|pillColor=White|pillShape=Round|pillSize=7|pillScore=1}}
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| {{PillImage|fileName=Bicalutamide_NDC_604290226.jpg|drugName=Bicalutamide|NDC=604290226|drugAuthor=Golden State Medical Supply, Inc.|ingredients=Bicalutamide[Bicalutamide]|pillImprint=BCM;50|dosageValue=50|dosageUnit=mg|pillColor=White|pillShape=Round|pillSize=7|pillScore=1}}
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| {{PillImage|fileName=Bicalutamide_NDC_00930220.jpg|drugName=Bicalutamide|NDC=00930220|drugAuthor=Teva Pharmaceuticals USA Inc|ingredients=BICALUTAMIDE[BICALUTAMIDE]|pillImprint=93;220|dosageValue=50|dosageUnit=mg|pillColor=White|pillShape=Round|pillSize=7|pillScore=1}}
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| {{PillImage|fileName=Bicalutamide_NDC_167140571.jpg|drugName=Bicalutamide|NDC=167140571|drugAuthor=Northstar Rx LLC|ingredients=BICALUTAMIDE[BICALUTAMIDE]|pillImprint=B;50|dosageValue=50|dosageUnit=mg|pillColor=White|pillShape=Round|pillSize=7|pillScore=1}}
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| == External links ==
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| * [http://www.astrazeneca.com/productbrowse/5_82.aspx Casodex, Cosudex] (manufacturer's website)
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| * [http://www.meds-help.com/bicalutamide/ Bicalutamide] (patient information)
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| {{Sex hormones}}
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| [[Category:Antiandrogens]]
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| [[nl:Bicalutamide]]
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