Mycobacterium abscessus: Difference between revisions
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==Overview== | ==Overview== | ||
Mycobacterium abscessus is a rapidly growing [[mycobacterium]] that is a common water contaminant. It was until recently (1992) thought to be a subspecies of [[Mycobacterium chelonae]]. ''M. abcessus'' can cause chronic lung disease, post-traumatic wound infections, and disseminated cutaneous diseases, mostly in patients with suppressed immune systems. | Mycobacterium abscessus is a rapidly growing [[mycobacterium]] that is a common water contaminant. It was until recently (1992) thought to be a subspecies of [[Mycobacterium chelonae]]. ''M. abcessus'' can cause chronic lung disease, post-traumatic wound infections, and disseminated cutaneous diseases, mostly in patients with suppressed immune systems. | ||
==Historical Perspective== | |||
''Mycobacterium abscessus'' was first isolated from gluteal abscesses in a 62-year-old patient who had injured her knee as a child and had a disseminated infection 48 years later. The species ''M. bolletii'', named after the late microbiologist and taxonomist [[Claude Bollet]], was described in 2006. In current taxonomy, ''M. bolletii'' and ''M. massiliense'' (named for Massilia, the ancient Greek and Roman name for Marseille, where the organism was isolated) have been incorporated into ''M. abscessus'' subsp. ''bolletii''. <ref> Etymologia: Mycobacterium abscessus subsp. bolletii. Emerg Infect Dis [Internet]. 2014 Mar [February 20, 2014]. http://dx.doi.org/10.3201/eid2003.ET2003 </ref> | |||
==Pathophysiology== | ==Pathophysiology== | ||
Revision as of 23:23, 22 July 2014
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| Mycobacterium abscessus Kusonoki and Ezaki 1992 ATCC 19977 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: M. abcessus
Overview
Mycobacterium abscessus is a rapidly growing mycobacterium that is a common water contaminant. It was until recently (1992) thought to be a subspecies of Mycobacterium chelonae. M. abcessus can cause chronic lung disease, post-traumatic wound infections, and disseminated cutaneous diseases, mostly in patients with suppressed immune systems.
Historical Perspective
Mycobacterium abscessus was first isolated from gluteal abscesses in a 62-year-old patient who had injured her knee as a child and had a disseminated infection 48 years later. The species M. bolletii, named after the late microbiologist and taxonomist Claude Bollet, was described in 2006. In current taxonomy, M. bolletii and M. massiliense (named for Massilia, the ancient Greek and Roman name for Marseille, where the organism was isolated) have been incorporated into M. abscessus subsp. bolletii. [1]
Pathophysiology
Microscopy
- Gram-positive, nonmotile and acid-fast rods (1.0-2.5µm x 0.5µm).
Colony characteristics
- Colonies on Löwenstein-Jensen media may occur as smooth as well as rough, white or greyish and nonphotochromogenic.
Physiology
- Growth at 28°C and 37°C after 7 days but not at 43°C.
- On MacConkey agar at 28°C and even 37°C.
- Tolerance to 5% NaCl and 500mg/l hydroxylamine (Ogawa egg medium) and 0.2% picrate (Sauton agar medium).
- Positive degradation of p-aminosalicylate.
- Production of arylsulfatase but not of nitrate reductase and Tween 80 hydrolase.
- Negative iron uptake test. No utilisation of fructose, glucose, oxalate and citrate as sole carbon sources.
Differential characteristics
- M. abscessus and M. chelonae can be distinguished from M. fortuitum or M. peregrinum by their failure to reduce nitrate and to take up iron.
- Tolerance to 5% NaCl in Löwenstein-Jensen media tolerance to 0.2% picrate in Sauton agar and non-utilisation of citrate as a sole carbon source are characteristics that distinguish M. abscessus from M. chelonae.
- M. abscessus and M. chelonae sequevar I share an identical sequence in the 54-510 region of 16S rRNA, However, both species can be differentiated by their hsp65 or ITS sequences
Strains
ATCC 19977 = CCUG 20993 = CIP 104536 = DSM 44196 = JCM 13569 = NCTC 13031
Genetics
A draft genome sequence of M. abscessus subsp. bolletii BDT was completed in 2012.[2] More than 25 different strains of this subspecies, including pathogenic isolates, have had their genomes sequenced.[3]
Risk Factors
The infection tends to occur in patients with chronic lung disease, post-traumatic wound infections, post-tympanostomy tube otitis media, and as a disseminated cutaneous diseases in patients of immune suppression.
References
- ↑ Etymologia: Mycobacterium abscessus subsp. bolletii. Emerg Infect Dis [Internet]. 2014 Mar [February 20, 2014]. http://dx.doi.org/10.3201/eid2003.ET2003
- ↑ Choi, G.-E.; Cho, Y.-J.; Koh, W.-J.; Chun, J.; Cho, S.-N.; Shin, S. J. (24 April 2012). "Draft Genome Sequence of Mycobacterium abscessus subsp. bolletii BDT". Journal of Bacteriology. 194 (10): 2756–2757. doi:10.1128/JB.00354-12.
- ↑ Davidson, Rebecca M. (December 2013). "Phylogenomics of Brazilian epidemic isolates of Mycobacterium abscessus subsp. bolletii reveals relationships of global outbreak strains". Infection, Genetics and Evolution. 20: 292–297. doi:10.1016/j.meegid.2013.09.012. Unknown parameter
|coauthors=ignored (help)
- Kusunoki,S.,T. Ezaki. 1992. Proposal of Mycobacterium peregrinum sp. nov., nom. rev., and elevation of Mycobacterium chelonae subsp. abscessus (Kubica et al.) to species status: Mycobacterium abscessus comb. nov. Int. J. Syst. Bacteriol. 42, 240-245.