Mycobacterium abscessus natural history, complications and prognosis: Difference between revisions
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* Bronchopulmonary infection<ref name="pmid22290346">{{cite journal| author=Nessar R, Cambau E, Reyrat JM, Murray A, Gicquel B| title=Mycobacterium abscessus: a new antibiotic nightmare. | journal=J Antimicrob Chemother | year= 2012 | volume= 67 | issue= 4 | pages= 810-8 | pmid=22290346 | doi=10.1093/jac/dkr578 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22290346 }} </ref> | * Bronchopulmonary infection<ref name="pmid22290346">{{cite journal| author=Nessar R, Cambau E, Reyrat JM, Murray A, Gicquel B| title=Mycobacterium abscessus: a new antibiotic nightmare. | journal=J Antimicrob Chemother | year= 2012 | volume= 67 | issue= 4 | pages= 810-8 | pmid=22290346 | doi=10.1093/jac/dkr578 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22290346 }} </ref> | ||
* Disseminated infection in non-[[AIDS]] immunocompromised patients<ref name="pmid22290346">{{cite journal| author=Nessar R, Cambau E, Reyrat JM, Murray A, Gicquel B| title=Mycobacterium abscessus: a new antibiotic nightmare. | journal=J Antimicrob Chemother | year= 2012 | volume= 67 | issue= 4 | pages= 810-8 | pmid=22290346 | doi=10.1093/jac/dkr578 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22290346 }} </ref> | * Disseminated infection in non-[[AIDS]] immunocompromised patients<ref name="pmid22290346">{{cite journal| author=Nessar R, Cambau E, Reyrat JM, Murray A, Gicquel B| title=Mycobacterium abscessus: a new antibiotic nightmare. | journal=J Antimicrob Chemother | year= 2012 | volume= 67 | issue= 4 | pages= 810-8 | pmid=22290346 | doi=10.1093/jac/dkr578 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22290346 }} </ref> | ||
* M. abscessus hand-and-foot disease<ref name="pmid16054324">{{cite journal| author=Dytoc MT, Honish L, Shandro C, Ting PT, Chui L, Fiorillo L et al.| title=Clinical, microbiological, and epidemiological findings of an outbreak of Mycobacterium abscessus hand-and-foot disease. | journal=Diagn Microbiol Infect Dis | year= 2005 | volume= 53 | issue= 1 | pages= 39-45 | pmid=16054324 | doi=10.1016/j.diagmicrobio.2005.03.010 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16054324 }} </ref><ref name="pmid24758202">{{cite journal| author=Sinagra JL, Kanitz EE, Cerocchi C, Cota C, Fantetti O, Prignano G et al.| title=Mycobacterium abscessus hand-and-foot disease in children: rare or emerging disease? | journal=Pediatr Dermatol | year= 2014 | volume= 31 | issue= 3 | pages= 292-7 | pmid=24758202 | doi=10.1111/pde.12333 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24758202 }} </ref> | |||
* Other rare infections | * Other rare infections | ||
** Vertebral [[osteomyelitis]]<ref name="pmid23925676">{{cite journal| author=Garcia DC, Sandoval-Sus J, Razzaq K, Young L| title=Vertebral osteomyelitis caused by Mycobacterium abscessus. | journal=BMJ Case Rep | year= 2013 | volume= 2013 | issue= | pages= | pmid=23925676 | doi=10.1136/bcr-2013-009597 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23925676 }} </ref> | ** Vertebral [[osteomyelitis]]<ref name="pmid23925676">{{cite journal| author=Garcia DC, Sandoval-Sus J, Razzaq K, Young L| title=Vertebral osteomyelitis caused by Mycobacterium abscessus. | journal=BMJ Case Rep | year= 2013 | volume= 2013 | issue= | pages= | pmid=23925676 | doi=10.1136/bcr-2013-009597 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23925676 }} </ref> | ||
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===Skin and Soft Tissue Infection=== | ===Skin and Soft Tissue Infection=== | ||
Minor infections with mycobacterium abscessus can resolve either spontaneously or following surgical debridement. In the absence of therapy, abscesses that occur after injection of the organism may last up to 8 to 12 months until they resolve spontaneously.<ref name="pmid17277290">{{cite journal| author=Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F et al.| title=An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. | journal=Am J Respir Crit Care Med | year= 2007 | volume= 175 | issue= 4 | pages= 367-416 | pmid=17277290 | doi=10.1164/rccm.200604-571ST | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17277290 }} </ref> | Minor infections with mycobacterium abscessus can resolve either spontaneously or following surgical debridement. In the absence of therapy, abscesses that occur after injection of the organism may last up to 8 to 12 months until they resolve spontaneously.<ref name="pmid17277290">{{cite journal| author=Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F et al.| title=An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. | journal=Am J Respir Crit Care Med | year= 2007 | volume= 175 | issue= 4 | pages= 367-416 | pmid=17277290 | doi=10.1164/rccm.200604-571ST | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17277290 }} </ref> | ||
M. abscessus hand-and-foot disease has been described in the pediatric population with wading and public pool exposure.<ref name="pmid16054324">{{cite journal| author=Dytoc MT, Honish L, Shandro C, Ting PT, Chui L, Fiorillo L et al.| title=Clinical, microbiological, and epidemiological findings of an outbreak of Mycobacterium abscessus hand-and-foot disease. | journal=Diagn Microbiol Infect Dis | year= 2005 | volume= 53 | issue= 1 | pages= 39-45 | pmid=16054324 | doi=10.1016/j.diagmicrobio.2005.03.010 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16054324 }} </ref><ref name="pmid24758202">{{cite journal| author=Sinagra JL, Kanitz EE, Cerocchi C, Cota C, Fantetti O, Prignano G et al.| title=Mycobacterium abscessus hand-and-foot disease in children: rare or emerging disease? | journal=Pediatr Dermatol | year= 2014 | volume= 31 | issue= 3 | pages= 292-7 | pmid=24758202 | doi=10.1111/pde.12333 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24758202 }} </ref> The disease is characterized by self limited tender, erythematous, pustules, papules, and abscesses in the hands and feet.<ref name="pmid16054324">{{cite journal| author=Dytoc MT, Honish L, Shandro C, Ting PT, Chui L, Fiorillo L et al.| title=Clinical, microbiological, and epidemiological findings of an outbreak of Mycobacterium abscessus hand-and-foot disease. | journal=Diagn Microbiol Infect Dis | year= 2005 | volume= 53 | issue= 1 | pages= 39-45 | pmid=16054324 | doi=10.1016/j.diagmicrobio.2005.03.010 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16054324 }} </ref><ref name="pmid24758202">{{cite journal| author=Sinagra JL, Kanitz EE, Cerocchi C, Cota C, Fantetti O, Prignano G et al.| title=Mycobacterium abscessus hand-and-foot disease in children: rare or emerging disease? | journal=Pediatr Dermatol | year= 2014 | volume= 31 | issue= 3 | pages= 292-7 | pmid=24758202 | doi=10.1111/pde.12333 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24758202 }} </ref> | |||
===Pulmonary Infection=== | ===Pulmonary Infection=== | ||
Revision as of 18:57, 23 July 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]
Overview
Natural History, Complications and Prognosis
Infection with Mycobacterium abscessus can lead to:
- Skin and soft tissue infection
- Open wound infection
- Sternal wound infection[1]
- Bronchopulmonary infection[2]
- Disseminated infection in non-AIDS immunocompromised patients[2]
- M. abscessus hand-and-foot disease[3][4]
- Other rare infections
- Vertebral osteomyelitis[5]
- Abdominal infection[6]
- Lymphadenitis[7]
Skin and Soft Tissue Infection
Minor infections with mycobacterium abscessus can resolve either spontaneously or following surgical debridement. In the absence of therapy, abscesses that occur after injection of the organism may last up to 8 to 12 months until they resolve spontaneously.[7]
M. abscessus hand-and-foot disease has been described in the pediatric population with wading and public pool exposure.[3][4] The disease is characterized by self limited tender, erythematous, pustules, papules, and abscesses in the hands and feet.[3][4]
Pulmonary Infection
Mycobacterium abscessus is the most common non tuberculosis mycobacterial infection in cystic fibrosis.[8] Chronic infection with Mycobacterium abscessus is associated with a decline in lung function among patients with cystic fibrosis.[9] The most commonly reported symptom is cough. Constitutional symptoms increase as the disease progresses. The only effective long-term therapy for Mycobacterium abscessus was reported to be surgical resection of the localized disease.[10] Death may occur in these patients (mortality in ~14% of patients) due to respiratory failure secondary to the progressive lung disease.[10]
When pulmonary mycobacterium abscessus infection occurs in the absence of any predisposing conditions, the course of the disease is slowly progressive and indolent. Whereas, when the pulmonary infection is associated with underlying predisposing factors, such as gastrointestinal or pulmonary conditions, the disease is rapidly progressive and fulminant.[10]
Surgical resection and multidrug antibiotic therapy is associated with a higher chance of a successful treatment.
References
- ↑ Hoffman PC, Fraser DW, Robicsek F, O'Bar PR, Mauney CU (1981). "Two outbreaks of sternal wound infection due to organisms of the Mycobacterium fortuitum complex". J Infect Dis. 143 (4): 533–42. PMID 7240799.
- ↑ 2.0 2.1 Nessar R, Cambau E, Reyrat JM, Murray A, Gicquel B (2012). "Mycobacterium abscessus: a new antibiotic nightmare". J Antimicrob Chemother. 67 (4): 810–8. doi:10.1093/jac/dkr578. PMID 22290346.
- ↑ 3.0 3.1 3.2 Dytoc MT, Honish L, Shandro C, Ting PT, Chui L, Fiorillo L; et al. (2005). "Clinical, microbiological, and epidemiological findings of an outbreak of Mycobacterium abscessus hand-and-foot disease". Diagn Microbiol Infect Dis. 53 (1): 39–45. doi:10.1016/j.diagmicrobio.2005.03.010. PMID 16054324.
- ↑ 4.0 4.1 4.2 Sinagra JL, Kanitz EE, Cerocchi C, Cota C, Fantetti O, Prignano G; et al. (2014). "Mycobacterium abscessus hand-and-foot disease in children: rare or emerging disease?". Pediatr Dermatol. 31 (3): 292–7. doi:10.1111/pde.12333. PMID 24758202.
- ↑ Garcia DC, Sandoval-Sus J, Razzaq K, Young L (2013). "Vertebral osteomyelitis caused by Mycobacterium abscessus". BMJ Case Rep. 2013. doi:10.1136/bcr-2013-009597. PMID 23925676.
- ↑ Ding LW, Lai CC, Lee LN, Hsueh PR (2006). "Abdominal nontuberculous mycobacterial infection in a university hospital in Taiwan from 1997 to 2003". J Formos Med Assoc. 105 (5): 370–6. doi:10.1016/S0929-6646(09)60132-7. PMID 16638646.
- ↑ 7.0 7.1 Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F; et al. (2007). "An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases". Am J Respir Crit Care Med. 175 (4): 367–416. doi:10.1164/rccm.200604-571ST. PMID 17277290.
- ↑ Sermet-Gaudelus I, Le Bourgeois M, Pierre-Audigier C, Offredo C, Guillemot D, Halley S; et al. (2003). "Mycobacterium abscessus and children with cystic fibrosis". Emerg Infect Dis. 9 (12): 1587–91. doi:10.3201/eid0912.020774. PMC 3034322. PMID 14720400.
- ↑ Esther CR, Esserman DA, Gilligan P, Kerr A, Noone PG (2010). "Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis". J Cyst Fibros. 9 (2): 117–23. doi:10.1016/j.jcf.2009.12.001. PMC 3837580. PMID 20071249.
- ↑ 10.0 10.1 10.2 Griffith DE, Girard WM, Wallace RJ (1993). "Clinical features of pulmonary disease caused by rapidly growing mycobacteria. An analysis of 154 patients". Am Rev Respir Dis. 147 (5): 1271–8. doi:10.1164/ajrccm/147.5.1271. PMID 8484642.