Aprindine: Difference between revisions

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Aprindine
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	C01BB04 (WHO) ;
Identifiers
	IUPAC name {3-[2,3-dihydro-1H-inden-2-yl(phenyl)amino]propyl}diethylamine;
CAS Number	37640-71-4;
PubChem CID	2218;
DrugBank	DB01429 ;
ChemSpider	2132 ;
UNII	5Y48085P9Q;
KEGG	D02969 ;
ChEMBL	ChEMBL1213033 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C22H30N2
Molar mass	322.487 g/mol
3D model (JSmol)	Interactive image;
	SMILES c1cccc3c1CC(N(c2ccccc2)CCCN(CC)CC)C3;
	InChI InChI=1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3 ; Key:NZLBHDRPUJLHCE-UHFFFAOYSA-N ;
(verify)

VisualWikitext

Latest revision as of 22:10, 23 July 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Aprindine is a Class 1b antiarrhythmic agent.^[1]

In one study, it delayed atrial fibrillation more than digoxin did.^[2]

It has shown effectiveness when given orally.^[3]

References

↑ Sato R, Hisatome I, Tanaka Y; et al. (September 1991). "Aprindine blocks the sodium current in guinea-pig ventricular myocytes". Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. doi:10.1007/bf00183008. PMID 1660104.
↑ Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). "Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation" (^{[dead link]}). Circ. J. 66 (6): 553–6. doi:10.1253/circj.66.553. PMID 12074271.
↑ Reid PR, Greene HL, Varghese PJ (December 1977). "Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome". Br Heart J. 39 (12): 1353–60. doi:10.1136/hrt.39.12.1353. PMC 483421. PMID 603737.

Template:Antiarrhythmic agents

[pmid1660104-1] Sato R, Hisatome I, Tanaka Y; et al. (September 1991). "Aprindine blocks the sodium current in guinea-pig ventricular myocytes". Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. doi:10.1007/bf00183008. PMID 1660104.

[pmid12074271-2] Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). "Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation" (^{[dead link]}). Circ. J. 66 (6): 553–6. doi:10.1253/circj.66.553. PMID 12074271.

[pmid603737-3] Reid PR, Greene HL, Varghese PJ (December 1977). "Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome". Br Heart J. 39 (12): 1353–60. doi:10.1136/hrt.39.12.1353. PMC 483421. PMID 603737.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-{{drugbox |
+{{Drugbox
-| IUPAC_name = ''N''<nowiki>'</nowiki>-(2,3-dihydro-1''H''-inden-2-yl)-''N'',''N''-diethyl-''N''<nowiki>'</nowiki>-<br>phenyl-propane-1,3-diamine
+| verifiedrevid = 443395414
+| IUPAC_name = {3-[2,3-dihydro-1''H''-inden-2-yl(phenyl)amino]propyl}diethylamine
 | image = Aprindine_svg.png
+<!--Clinical data-->
+| tradename =
+| Drugs.com = {{drugs.com|international|aprindine}}
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
+| pregnancy_US = <!-- A / B            / C / D / X -->
+| pregnancy_category =
+| legal_AU = <!-- Unscheduled / S2 / S3 / S4  / S8 -->
+| legal_UK = <!-- GSL         / P       / POM / CD -->
+| legal_US = <!-- OTC                   / Rx-only  -->
+| legal_status =
+| routes_of_administration =
+<!--Pharmacokinetic data-->
+| bioavailability =
+| protein_bound =
+| metabolism =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CASNo_Ref = {{cascite|correct|CAS}}
 | CAS_number = 37640-71-4
 | ATC_prefix = C01
 | ATC_suffix = BB04
 | PubChem = 2218
-| DrugBank =
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
-| C = 22 | H = 30 | N = 2
+| DrugBank = DB01429
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 2132
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = 5Y48085P9Q
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D02969
+| ChEMBL_Ref = {{ebicite|correct|EBI}}
+| ChEMBL = 1213033
+<!--Chemical data-->
+| C=22 | H=30 | N=2
 | molecular_weight = 322.487 g/mol
-| bioavailability =
+| smiles = c1cccc3c1CC(N(c2ccccc2)CCCN(CC)CC)C3
-| protein_bound =
+| InChI = 1/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3
-| metabolism =
+| InChIKey = NZLBHDRPUJLHCE-UHFFFAOYAO
-| elimination_half-life =
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
-| excretion =
+| StdInChI = 1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3
-| pregnancy_AU =  <!-- A / B1 / B2 / B3 / C / D / X -->
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
-| pregnancy_US =  <!-- A / B            / C / D / X -->
+| StdInChIKey = NZLBHDRPUJLHCE-UHFFFAOYSA-N
-| pregnancy_category =
-| legal_AU =      <!-- Unscheduled / S2 / S3 / S4  / S8 -->
-| legal_UK =      <!-- GSL         / P       / POM / CD -->
-| legal_US =      <!-- OTC                   / Rx-only  -->
-| legal_status =
-| routes_of_administration =
 }}
 __NOTOC__
+{{SI}}
 {{CMG}}
+==Overview==
+'''Aprindine''' is a Class 1b [[antiarrhythmic agent]].<ref name="pmid1660104">{{cite journal |author=Sato R, Hisatome I, Tanaka Y, ''et al.'' |title=Aprindine blocks the sodium current in guinea-pig ventricular myocytes |journal=Naunyn Schmiedebergs Arch. Pharmacol. |volume=344 |issue=3 |pages=331–6 |date=September 1991 |pmid=1660104 |doi= 10.1007/bf00183008|url=}}</ref>
+In one study, it delayed [[atrial fibrillation]] more than [[digoxin]] did.<ref name="pmid12074271">{{cite journal |author=Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H |title=Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation |journal=Circ. J. |volume=66 |issue=6 |pages=553–6 |date=June 2002 |pmid=12074271 |doi= 10.1253/circj.66.553|url=http://joi.jlc.jst.go.jp/JST.JSTAGE/circj/66.553?from=PubMed |format={{dead link|date=May 2010}}}}</ref>
+It has shown effectiveness when given orally.<ref name="pmid603737">{{cite journal |author=Reid PR, Greene HL, Varghese PJ |title=Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome |journal=Br Heart J |volume=39 |issue=12 |pages=1353–60 |date=December 1977 |pmid=603737 |pmc=483421 |doi= 10.1136/hrt.39.12.1353|url=http://heart.bmj.com/cgi/pmidlookup?view=long&pmid=603737}}</ref>
+==References==
+{{reflist|2}}
-==Overview==
-'''Aprindine''' is a Class 1b [[antiarrhythmic agent]].
 {{Antiarrhythmic agents}}
 [[Category:Antiarrhythmic agents]]
-[[Category:Drugs]]
+[[Category:Cardiovascular Drugs]]
-{{WikiDoc Help Menu}}
+[[Category:Drug]]
-{{WikiDoc Sources}}

Aprindine: Difference between revisions

Latest revision as of 22:10, 23 July 2014

Overview

References

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