Fenoldopam: Difference between revisions

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__NOTOC__
{{DrugProjectFormSinglePage
{{Fenoldopam}}
|authorTag=
{{CMG}}; {{AE}} {{SS}}


'''''For patient information about Fenoldopam, click [[Fenoldopam (patient information)|here]].'''''
Gerald Chi


{{SB}} CORLOPAM<sup>®</sup>
<!--Overview-->


==Overview==
|genericName=


'''Fenoldopam mesylate''' ('''Corlopam''') is a [[drug]] and [[Synthetic chemical|synthetic]] [[benzazepine]] [[chemical derivative|derivative]] which acts as a [[binding selectivity|selective]] [[D1 receptor|D<sub>1</sub> receptor]] [[partial agonist]].<ref>{{cite journal |author=Grenader A, Healy DP |title=Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells |journal=J. Pharmacol. Exp. Ther. |volume=258 |issue=1 |pages=193–8 |date=July 1991 |pmid=1677038 |doi= |url=}}</ref> Fenoldopam is used as an [[antihypertensive]] agent.<ref name="pmid17000789">{{cite journal |author=Oliver WC, Nuttall GA, Cherry KJ, Decker PA, Bower T, Ereth MH |title=A comparison of fenoldopam with dopamine and sodium nitroprusside in patients undergoing cross-clamping of the abdominal aorta |journal=Anesth. Analg. |volume=103 |issue=4 |pages=833–40 |date=October 2006 |pmid=17000789 |doi=10.1213/01.ane.0000237273.79553.9e |url=http://www.anesthesia-analgesia.org/cgi/pmidlookup?view=long&pmid=17000789}}</ref> It was approved by the [[Food and Drug Administration]] (FDA) in September 1997.<ref>http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Label_ApprovalHistory  accessed November 14, 2011</ref>
==Category==


Benzazepines;D1-receptor agonists;Phenols;Organochlorides;Cardiovascular Drugs


====CORLOPAM (fenoldopam mesylate) injection, solution ====
|aOrAn=


'''  [[Fenoldopam indications and usage|Indications and Usage]]'''
a
'''| [[Fenoldopam dosage and administration|Dosage and Administration]]'''
'''| [[Fenoldopam dosage forms and strengths|Dosage Forms and Strengths]]'''
'''| [[Fenoldopam contraindications|Contraindications]]'''
'''| [[Fenoldopam warnings and precautions|Warnings and Precautions]]'''
'''| [[Fenoldopam adverse reactions|Adverse Reactions]]'''
'''| [[Fenoldopam drug interactions|Drug Interactions]]'''
'''| [[Fenoldopam use in specific populations|Use in Specific Populations]]'''
'''| [[Fenoldopam overdosage|Overdosage]]'''
'''| [[Fenoldopam description|Description]]'''
'''| [[Fenoldopam clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Fenoldopam nonclinical toxicology|Nonclinical Toxicology]]'''
'''| [[Fenoldopam clinical studies|Clinical Studies]]'''
'''| [[Fenoldopam how supplied storage and handling|How Supplied/Storage and Handling]]'''
'''| [[Fenoldopam patient counseling information|Patient Counseling Information]]'''
'''| [[Fenoldopam labels and packages|Labels and Packages]]'''


==Mechanism of Action==
|drugClass=


Fenoldopam is a rapid-acting vasodilator. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and β adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam is a racemic mixture with the R-isomer responsible for the biological activity. The R-isomer has approximately 250-fold higher affinity for D1-like receptors than does the S-isomer. In non-clinical studies, fenoldopam had no agonist effect on presynaptic D2-like dopamine receptors, or α- or β-adrenoceptors, nor did it affect angiotensin-converting enzyme activity. Fenoldopam may increase norepinephrine plasma concentration.


In animals, fenoldopam has vasodilating effects in coronary, renal, mesenteric and peripheral arteries. All vascular beds, however, do not respond uniformly to fenoldopam. Vasodilating effects have been demonstrated in renal efferent and afferent arterioles.
== References ==
{{Reflist|2}}


{{Sympatholytic antihypertensives}}
|indication=
{{Dopaminergics}}


[[Category:Benzazepines]]
 
[[Category:D1-receptor agonists]]
 
[[Category:Phenols]]
|hasBlackBoxWarning=
[[Category:Organochlorides]]
 
Yes
 
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<!--Category-->
 
[[Category:Cardiovascular Drugs]]
[[Category:Drug]]

Revision as of 00:38, 24 July 2014

Fenoldopam
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gerald Chi

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Black Box Warning

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Fenoldopam is a that is FDA approved for the {{{indicationType}}} of . There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Fenoldopam in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Fenoldopam in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Fenoldopam in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Fenoldopam in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Fenoldopam in pediatric patients.

Contraindications

  • Condition1

Warnings

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Fenoldopam in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Fenoldopam in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Fenoldopam in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Fenoldopam during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Fenoldopam with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Fenoldopam with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Fenoldopam with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Fenoldopam with respect to specific gender populations.

Race

There is no FDA guidance on the use of Fenoldopam with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Fenoldopam in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Fenoldopam in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Fenoldopam in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Fenoldopam in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Fenoldopam in the drug label.

Condition1
  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Fenoldopam in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Fenoldopam in the drug label.

Pharmacology

There is limited information regarding Fenoldopam Pharmacology in the drug label.

Mechanism of Action

Structure

File:Fenoldopam01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Fenoldopam in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Fenoldopam in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Fenoldopam in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Fenoldopam in the drug label.

Condition1
  • Description

How Supplied

Storage

There is limited information regarding Fenoldopam Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Fenoldopam |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Fenoldopam |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Fenoldopam in the drug label.

Precautions with Alcohol

  • Alcohol-Fenoldopam interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)


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