Malaria laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
The [[diagnosis]] of [[malaria]] should be complemented by laboratory tests, which may reveal: [[anemia]] with decreased [[hemoglobin]], [[hematocrit]], [[haptoglobin]] and | The [[diagnosis]] of [[malaria]] should be complemented by laboratory tests, which may reveal: [[anemia]] with decreased [[hemoglobin]], [[hematocrit]], [[haptoglobin]] and microcitosis; and [[leukocyte]] count, which may be elevated or decreased. Biochemistry may reveal [[hypoglycemia]], elevated [[creatinine]] and [[LDH]]; [[acidosis]] expressed by an elevated [[lactate]] level and decreased [[bicarbonate]] level; and mild [[hyponatremia]] due to [[vomiting]] and [[diarrhea]]. In severe disease there may be some [[renal]] impairment, which will be expressed by [[proteinuria]] and [[hemoglobinuria]].<ref name=CDC>{{cite web | title = Malaria | url = http://www.cdc.gov/malaria/about/disease.html }}</ref><ref>{{cite book | last = Mandell | first = Gerald | title = Mandell, Douglas, and Bennett's principles and practice of infectious diseases | publisher = Churchill Livingstone/Elsevier | location = Philadelphia, PA | year = 2010 | isbn = 0443068399 }}</ref> | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Revision as of 20:37, 24 July 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
The diagnosis of malaria should be complemented by laboratory tests, which may reveal: anemia with decreased hemoglobin, hematocrit, haptoglobin and microcitosis; and leukocyte count, which may be elevated or decreased. Biochemistry may reveal hypoglycemia, elevated creatinine and LDH; acidosis expressed by an elevated lactate level and decreased bicarbonate level; and mild hyponatremia due to vomiting and diarrhea. In severe disease there may be some renal impairment, which will be expressed by proteinuria and hemoglobinuria.[1][2]
Laboratory Findings
Whenever possible, the diagnosis of malaria should be confirmed by laboratory tests.
The table below displays the nonspecific laboratory abnormalities associated with malaria:[1][3]
| Test | Findings |
|---|---|
| Complete Blood Count | Decreased Hemoglobin Decreased Hematocrit Microcytosis Decreased Haptoglobin |
| White blood cell count | Elevated or Decreased Leukocyte Count |
| Biochemistry | Hypoglycemia Elevated Creatinine Elevated LDH Possible Hyponatremia Acidosis: High Lactate; Low Bicarbonate |
| Coagulation | Thrombocytopenia |
| Urinalysis | Proteinuria Hemoglobinuria |
References
- ↑ 1.0 1.1 "Malaria".
- ↑ Mandell, Gerald (2010). Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Philadelphia, PA: Churchill Livingstone/Elsevier. ISBN 0443068399.
- ↑ Mandell, Gerald (2010). Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Philadelphia, PA: Churchill Livingstone/Elsevier. ISBN 0443068399.