Pinacidil: Difference between revisions
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==Overview== | ==Overview== | ||
'''Pinacidil''' is a | '''Pinacidil''' is a cyanoguanidine drug that opens [[ATP-sensitive potassium channel]]s producing peripheral [[vasodilatation]] of [[arteriole]]s.<ref name="pmid7473155">{{cite journal | author = Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, Haller H | title = Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells | journal = J. Pharmacol. Exp. Ther. | volume = 275 | issue = 2 | pages = 681–92 | year = 1995 | pmid = 7473155 | doi = | url = http://jpet.aspetjournals.org/cgi/content/abstract/275/2/681 | issn = }}</ref> It reduces [[blood pressure]] and peripheral resistance and produces fluid retention.<ref name="isbn0-85369-342-0">{{cite book | author = Reynolds, James Blair; Martindale, William L. | title = The extra pharmacopoeia | publisher = Royal Pharmaceutical Society | location = London | year = 1996 | edition = 31st | pages = 2739 pages | isbn = 0-85369-342-0 | oclc = | doi = }}</ref> | ||
==References== | ==References== | ||
Revision as of 00:26, 25 July 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles.[1] It reduces blood pressure and peripheral resistance and produces fluid retention.[2]
References
- ↑ Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, Haller H (1995). "Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells". J. Pharmacol. Exp. Ther. 275 (2): 681–92. PMID 7473155.
- ↑ Reynolds, James Blair; Martindale, William L. (1996). The extra pharmacopoeia (31st ed.). London: Royal Pharmaceutical Society. pp. 2739 pages. ISBN 0-85369-342-0.
External links
- Pinacidil at the US National Library of Medicine Medical Subject Headings (MeSH)