Clopamide: Difference between revisions

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Evidence Based Medicine
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Clinical Trials
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List of terms related to Clopamide

Clopamide
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	C03BA03 (WHO) ;
Identifiers
	IUPAC name 4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-; benzamide;
CAS Number	636-54-4 ;
PubChem CID	2804;
ChemSpider	2702 ;
UNII	17S83WON0I;
KEGG	D02460 ;
ChEMBL	ChEMBL1361347;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C14H20ClN3O3S
Molar mass	345.846 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C(NN1C(CCCC1C)C)c2ccc(Cl)c(c2)S(=O)(=O)N;
	InChI InChI=1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21) ; Key:LBXHRAWDUMTPSE-UHFFFAOYSA-N ;
(verify)

VisualWikitext

Revision as of 01:08, 25 July 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Clopamide (trade name Brinaldix) is a piperidine diuretic.^[1]

Mechanism of Action

Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the proximal convoluted tubule (PCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.

References

↑ PMID 3621784 (PMID 3621784)
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[1] PMID 3621784 (PMID 3621784)
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[1]

@@ Line 1: / Line 1: @@
-{{drugbox |
+{{Drugbox
+| verifiedrevid = 447611902
 | IUPAC_name = 4-chloro-''N''-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-<br>benzamide
-| image = Clopamide.svg
+| image = Clopamide.png
+| image2 = Clopamide ball-and-stick.png
+<!--Clinical data-->
+| tradename =
+| Drugs.com = {{drugs.com|international|clopamide}}
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
+| pregnancy_US = <!-- A / B            / C / D / X -->
+| pregnancy_category =
+| legal_AU = <!-- Unscheduled / S2 / S3 / S4  / S8 -->
+| legal_UK = <!-- GSL         / P       / POM / CD -->
+| legal_US = <!-- OTC                   / Rx-only  -->
+| legal_status =
+| routes_of_administration =
+<!--Pharmacokinetic data-->
+| bioavailability =
+| protein_bound =
+| metabolism =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|correct|??}}
 | CAS_number = 636-54-4
 | ATC_prefix = C03
 | ATC_suffix = BA03
 | PubChem = 2804
-| DrugBank =
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
-| C=14 | H=20 | Cl=1 | N=3 | O=3 | S=1
+| DrugBank =
+| ChEMBL = 1361347
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 2702
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = 17S83WON0I
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D02460
+<!--Chemical data-->
+| C=14 | H=20 | Cl=1 | N=3 | O=3 | S=1
 | molecular_weight = 345.846 g/mol
-| bioavailability =
+| smiles = O=C(NN1C(CCCC1C)C)c2ccc(Cl)c(c2)S(=O)(=O)N
-| protein_bound =
+| InChI = 1/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)
-| metabolism =
+| InChIKey = LBXHRAWDUMTPSE-UHFFFAOYAR
-| elimination_half-life =
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
-| excretion =
+| StdInChI = 1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)
-| pregnancy_AU =  <!-- A / B1 / B2 / B3 / C / D / X -->
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
-| pregnancy_US =  <!-- A / B            / C / D / X -->
+| StdInChIKey = LBXHRAWDUMTPSE-UHFFFAOYSA-N
-| pregnancy_category =
-| legal_AU =      <!-- Unscheduled / S2 / S3 / S4  / S8 -->
-| legal_UK =      <!-- GSL         / P       / POM / CD -->
-| legal_US =      <!-- OTC                   / Rx-only  -->
-| legal_status =
-| routes_of_administration =
 }}
-'''Clopamide''' is a [[piperidine]] [[diuretic]].
+__NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
+'''Clopamide''' (trade name '''Brinaldix''') is a [[piperidine]] [[diuretic]].<ref>{{cite pmid|3621784}}</ref>
-{{drug-stub}}
+==Mechanism of Action==
+Clopamide is categorised as a [[thiazide-like diuretic]] and works in similar way as the [[thiazide]] diuretics do. It acts in the kidneys, at the [[proximal convoluted tubule]] (PCT) of the [[nephron]] where it inhibits the [[sodium-chloride symporter]]. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of [[sodium chloride]], causing an equi[[osmolar]] excretion of water along with sodium chloride.
+==References==
+{{reflist|2}}
-[[pl:Klopamid]]
 [[Category:Diuretics]]
-[[Category:Piperidines]]
+[[Category:Thiazides]]
+[[Category:Sulfonamides]]
+[[Category:Cardiovascular Drugs]]
+[[Category:Drug]]
-Mechanism of Action of Clopamide: Clopamide is categorised as a thiazide like drug and works in similar way as the thiazide diuretics do. It acts at the Proximal Convoluted tubule site of the nephron where it inhibits the sodium-chloride cotransporter. Clopamide selectively binds at the chloride binding site of the sodium chloride cotransporter in the PCT cells on the luminal side and thus intereferes with the reabsorption of NaCl and thus causing an equiosmolar excretion of water along with NaCl.

Clopamide: Difference between revisions

Revision as of 01:08, 25 July 2014

Overview

Mechanism of Action

References

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