WBR0465

Author	[[PageAuthor::Rim Halaby, M.D. [1]]]
Exam Type	ExamType::USMLE Step 1
Main Category	MainCategory::Microbiology
Sub Category	SubCategory::Genitourinary
Prompt	[[Prompt::A 60-year-old female presents to the physician’s office with post-coital bleeding. Following appropriate work-up, the pathology identified in this patient is similar to the image shown below. physician explains to the patient that her condition is caused by a sexually transmitted virus. The Which of the following characteristics appropriately describes the virus implicated in this patient's pathology? ]]
Answer A	AnswerA::Double-stranded, non-enveloped DNA virus
Answer A Explanation	AnswerAExp::Human papilloma virus (HPV) is a double-stranded, non-enveloped DNA virus
Answer B	AnswerB::Double-stranded, enveloped DNA virus
Answer B Explanation	AnswerBExp::HPV is a non-enveloped virus
Answer C	AnswerC::Single-stranded, non-enveloped DNA virus
Answer C Explanation	AnswerCExp::HPV is a double-stranded virus.
Answer D	AnswerD::Single-stranded, enveloped RNA virus.
Answer D Explanation	AnswerDExp::HPV is a double-stranded, non-enveloped DNA virus.
Answer E	AnswerE::Double-stranded, non-enveloped RNA virus
Answer E Explanation	AnswerEExp::HPV is a DNA virus
Right Answer	RightAnswer::A
Explanation	[[Explanation::The patient is presenting with an abnormal pap-smear that shows koilocytes. Koilocytes are abnormal cells that have been infected by human papilloma virus (HPV). The image shown above shows a normal cervical cell on the left, and a koilocyte defined as an HPV-infected cell, on the right side that is characterized by large nuclei with perinuclear halo. HPV infection is a sexually transmitted infection (STI). The virus is a double-stranded non-envolved DNA virus. Among the most important HPV types are HPV types 16, 18, 31, 33, and 45 which predispose to cervical cancer; and 6, 11, 42, 43, and 44 which cause genital warts. Educational Objective: Koilocytes, defined as enlarged nuclei with perinuclear halo, are infected cells with HPV. HPV is a sexually transmitted virus that has at least a 100 types described, some of which predispose to cervical cancer and some cause genital warts. Educational Objective: References: ]]
Approved	Approved::No
Keyword	WBRKeyword::double, WBRKeyword::stranded, WBRKeyword::double stranded, WBRKeyword::DNA, WBRKeyword::non enveloped, WBRKeyword::non-enveloped, WBRKeyword::non, WBRKeyword::enveloped, WBRKeyword::HPV, WBRKeyword::human, WBRKeyword::papilloma, WBRKeyword::virus, WBRKeyword::human papilloma virus, WBRKeyword::genital, WBRKeyword::warts, WBRKeyword::genital warts, WBRKeyword::cervical, WBRKeyword::cancer, WBRKeyword::risk, WBRKeyword::factor, WBRKeyword::sexual, WBRKeyword::partner, WBRKeyword::multiple
Linked Question	Linked::
Order in Linked Questions	LinkedOrder::