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==Overview==
==Overview==
[[Hepatitis A virus]] was first identified in 1973. The [[incidence]] of [[hepatitis A]] varies among eras, countries and even cities within the same country. In recent years it has been noted a shift in [[prevalence]], what was once a disease more prevalent in children, is today predominant in adults. In the prevaccine era, the majority of U.S. cases of hepatitis A resulted from person-to-person [[transmission]] of [[HAV]] during communitywide outbreaks. With the licensure of inactivated hepatitis A vaccines by the Food and Drug Administration (FDA) during 1995-1996, hepatitis A became a disease that was not only common but also vaccine-preventable.
[[Hepatitis A virus]] was first identified in 1973. The [[incidence]] of [[hepatitis A]] varies among eras, countries and even cities within the same country.


==Historical Perspective==
==Historical Perspective==
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The [[incidence]] of [[hepatitis A]] varies among eras, countries and even cities within the same country. In recent years it has been noted a shift in prevalence, what was once a disease more prevalent in children, is today predominant in adults.
The [[incidence]] of [[hepatitis A]] varies among eras, countries and even cities within the same country. In recent years it has been noted a shift in prevalence, what was once a disease more prevalent in children, is today predominant in adults.


The measurement of anti-[[HAV]] [[antibodies]] is the best definition of the disease's true [[epidemiology]].
The resistance of the [[virus]] allows it to survive in urban sewage. Accordingly, [[outbreaks]] of the disease occur in overcrowded areas where there is poor sanitation. Improvements made throughout the years have decreased the [[incidence]] of the [[infection]] in new infants, which has led to an increasing number of adults with [[hepatitis A]]. [[Hepatitis A]] [[epidemiology]] in the United States has changed with licensure of [[hepatitis A]] [[vaccine]] and implementation of national ACIP recommendations for its use.


The resistance of the [[virus]] allows it to survive in urban sewage. Accordingly, [[outbreaks]] of the disease occur in overcrowded areas where there is poor sanitation. Improvements made throughout the years have decreased the [[incidence]] of the [[infection]] in new infants, which has led to an increasing number of adults with [[hepatitis A]]. [[Hepatitis A]] [[epidemiology]] in the United States has changed with licensure of [[hepatitis A]] [[vaccine]] and implementation of national ACIP recommendations for its use.
During 1995-1996, the Food and Drug Administration (FDA) approved the inactivated hepatitis A vaccines. Consequently, [[hepatitis A]] became a disease that was not only common but also vaccine-preventable.


Today [[transmission]] of the [[virus]] through blood is rare, however, some risk groups such as IV drug users and their care takers are still [[infected]] by this route.<ref name="pmid7876643    [">{{cite journal| author=Melnick JL| title=History and epidemiology of hepatitis A virus. | journal=J Infect Dis | year= 1995 | volume= 171 Suppl 1 | issue=  | pages= S2-8 | pmid=7876643    [ | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7876643  }} </ref>
Today [[transmission]] of the [[virus]] through [[blood]] is rare, however, some risk groups such as IV drug users and their care takers are still [[infected]] by this route.<ref name="pmid7876643    [">{{cite journal| author=Melnick JL| title=History and epidemiology of hepatitis A virus. | journal=J Infect Dis | year= 1995 | volume= 171 Suppl 1 | issue=  | pages= S2-8 | pmid=7876643    [ | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7876643  }} </ref>


==References==
==References==

Revision as of 21:41, 29 July 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Hepatitis A virus was first identified in 1973. The incidence of hepatitis A varies among eras, countries and even cities within the same country.

Historical Perspective

Hepatitis A virus was first identified in 1973. It was classified as a separate disease from other types of hepatitis during World War II. However, its true prevalence and route of transmission would only be recognized later.[1]

The incidence of hepatitis A varies among eras, countries and even cities within the same country. In recent years it has been noted a shift in prevalence, what was once a disease more prevalent in children, is today predominant in adults.

The resistance of the virus allows it to survive in urban sewage. Accordingly, outbreaks of the disease occur in overcrowded areas where there is poor sanitation. Improvements made throughout the years have decreased the incidence of the infection in new infants, which has led to an increasing number of adults with hepatitis A. Hepatitis A epidemiology in the United States has changed with licensure of hepatitis A vaccine and implementation of national ACIP recommendations for its use.

During 1995-1996, the Food and Drug Administration (FDA) approved the inactivated hepatitis A vaccines. Consequently, hepatitis A became a disease that was not only common but also vaccine-preventable.

Today transmission of the virus through blood is rare, however, some risk groups such as IV drug users and their care takers are still infected by this route.[1]

References

  1. 1.0 1.1 Melnick JL (1995). "History and epidemiology of hepatitis A virus". J Infect Dis. 171 Suppl 1: S2–8. PMID [ 7876643 [ Check |pmid= value (help).

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