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==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
==Genotyping== | ===Genotyping=== | ||
The use of [[genotyping]] as a [[diagnostic test]] is gaining acceptance among different countries. The association of [[HDV]] [[genotype]] 1 with a higher degree of [[liver disease]], and with a worst response to treatment with pegylated [[IFN]] justify the importance of this test.<ref name="pmid16697726">{{cite journal| author=Su CW, Huang YH, Huo TI, Shih HH, Sheen IJ, Chen SW et al.| title=Genotypes and viremia of hepatitis B and D viruses are associated with outcomes of chronic hepatitis D patients. | journal=Gastroenterology | year= 2006 | volume= 130 | issue= 6 | pages= 1625-35 | pmid=16697726 | doi=10.1053/j.gastro.2006.01.035 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16697726 }} </ref> | The use of [[genotyping]] as a [[diagnostic test]] is gaining acceptance among different countries. The association of [[HDV]] [[genotype]] 1 with a higher degree of [[liver disease]], and with a worst response to treatment with pegylated [[IFN]] justify the importance of this test.<ref name="pmid16697726">{{cite journal| author=Su CW, Huang YH, Huo TI, Shih HH, Sheen IJ, Chen SW et al.| title=Genotypes and viremia of hepatitis B and D viruses are associated with outcomes of chronic hepatitis D patients. | journal=Gastroenterology | year= 2006 | volume= 130 | issue= 6 | pages= 1625-35 | pmid=16697726 | doi=10.1053/j.gastro.2006.01.035 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16697726 }} </ref> | ||
[[HDV]] [[genotyping]] is not indicated in North America and Europe as a diagnostic tool, not only because [[genotype]] 1 is the most common type in these regions, but also because the different [[genotype]]s have responded well to common [[antiviral]] treatments.<ref name="pmid23242761">{{cite journal| author=Heidrich B, Manns MP, Wedemeyer H| title=Treatment options for hepatitis delta virus infection. | journal=Curr Infect Dis Rep | year= 2013 | volume= 15 | issue= 1 | pages= 31-8 | pmid=23242761 | doi=10.1007/s11908-012-0307-z | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23242761 }} </ref> | [[HDV]] [[genotyping]] is not indicated in North America and Europe as a diagnostic tool, not only because [[genotype]] 1 is the most common type in these regions, but also because the different [[genotype]]s have responded well to common [[antiviral]] treatments.<ref name="pmid23242761">{{cite journal| author=Heidrich B, Manns MP, Wedemeyer H| title=Treatment options for hepatitis delta virus infection. | journal=Curr Infect Dis Rep | year= 2013 | volume= 15 | issue= 1 | pages= 31-8 | pmid=23242761 | doi=10.1007/s11908-012-0307-z | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23242761 }} </ref> | ||
===Endoscopy=== | ===Endoscopy=== | ||
*Patients with [[liver cirrhosis]] should be evaluated for the presence of [[esophageal varices]].<ref name="pmid23242761">{{cite journal| author=Heidrich B, Manns MP, Wedemeyer H| title=Treatment options for hepatitis delta virus infection. | journal=Curr Infect Dis Rep | year= 2013 | volume= 15 | issue= 1 | pages= 31-8 | pmid=23242761 | doi=10.1007/s11908-012-0307-z | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23242761 }} </ref><ref name="pmid19840253">{{cite journal| author=Zachou K, Yurdaydin C, Drebber U, Dalekos GN, Erhardt A, Cakaloglu Y et al.| title=Quantitative HBsAg and HDV-RNA levels in chronic delta hepatitis. | journal=Liver Int | year= 2010 | volume= 30 | issue= 3 | pages= 430-7 | pmid=19840253 | doi=10.1111/j.1478-3231.2009.02140.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19840253 }} </ref> | *Patients with [[liver cirrhosis]] should be evaluated for the presence of [[esophageal varices]].<ref name="pmid23242761">{{cite journal| author=Heidrich B, Manns MP, Wedemeyer H| title=Treatment options for hepatitis delta virus infection. | journal=Curr Infect Dis Rep | year= 2013 | volume= 15 | issue= 1 | pages= 31-8 | pmid=23242761 | doi=10.1007/s11908-012-0307-z | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23242761 }} </ref><ref name="pmid19840253">{{cite journal| author=Zachou K, Yurdaydin C, Drebber U, Dalekos GN, Erhardt A, Cakaloglu Y et al.| title=Quantitative HBsAg and HDV-RNA levels in chronic delta hepatitis. | journal=Liver Int | year= 2010 | volume= 30 | issue= 3 | pages= 430-7 | pmid=19840253 | doi=10.1111/j.1478-3231.2009.02140.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19840253 }} </ref> | ||
Revision as of 22:04, 10 August 2014
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Hepatitis D |
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Hepatitis D other diagnostic studies On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Varun Kumar, M.B.B.S. [2]; João André Alves Silva, M.D. [3] Jolanta Marszalek, M.D. [4]
Overview
Other Diagnostic Studies
Genotyping
The use of genotyping as a diagnostic test is gaining acceptance among different countries. The association of HDV genotype 1 with a higher degree of liver disease, and with a worst response to treatment with pegylated IFN justify the importance of this test.[1]
HDV genotyping is not indicated in North America and Europe as a diagnostic tool, not only because genotype 1 is the most common type in these regions, but also because the different genotypes have responded well to common antiviral treatments.[2]
Endoscopy
- Patients with liver cirrhosis should be evaluated for the presence of esophageal varices.[2][3]
References
- ↑ Su CW, Huang YH, Huo TI, Shih HH, Sheen IJ, Chen SW; et al. (2006). "Genotypes and viremia of hepatitis B and D viruses are associated with outcomes of chronic hepatitis D patients". Gastroenterology. 130 (6): 1625–35. doi:10.1053/j.gastro.2006.01.035. PMID 16697726.
- ↑ 2.0 2.1 Heidrich B, Manns MP, Wedemeyer H (2013). "Treatment options for hepatitis delta virus infection". Curr Infect Dis Rep. 15 (1): 31–8. doi:10.1007/s11908-012-0307-z. PMID 23242761.
- ↑ Zachou K, Yurdaydin C, Drebber U, Dalekos GN, Erhardt A, Cakaloglu Y; et al. (2010). "Quantitative HBsAg and HDV-RNA levels in chronic delta hepatitis". Liver Int. 30 (3): 430–7. doi:10.1111/j.1478-3231.2009.02140.x. PMID 19840253.