Hepatitis E laboratory tests: Difference between revisions
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Throughout the course of infection, serologic markers will vary according to the stage of the disease:<ref name="pmid23013075">{{cite journal| author=Hoofnagle JH, Nelson KE, Purcell RH| title=Hepatitis E. | journal=N Engl J Med | year= 2012 | volume= 367 | issue= 13 | pages= 1237-44 | pmid=23013075 | doi=10.1056/NEJMra1204512 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23013075 }} </ref> | Throughout the course of infection, serologic markers will vary according to the stage of the disease:<ref name="pmid23013075">{{cite journal| author=Hoofnagle JH, Nelson KE, Purcell RH| title=Hepatitis E. | journal=N Engl J Med | year= 2012 | volume= 367 | issue= 13 | pages= 1237-44 | pmid=23013075 | doi=10.1056/NEJMra1204512 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23013075 }} </ref> | ||
* '''Incubation period''' | * '''Incubation period''' | ||
:*Rise of [[viremia]] | |||
:*Detection of [[HEV]] in stool | |||
* '''Symptom onset''' | * '''Symptom onset''' | ||
:*[[IgM]] and [[IgG]] antibody detection | |||
:*Elevations on serum [[aminotransferase]] and [[symptom]] onset | |||
:*[[HEV]] detected in stool | |||
* '''Recovery''' | * '''Recovery''' | ||
:*[[Viral clearance]] | |||
:*Increase of [[IgG]] titers | |||
:*Decrease of [[IgM]] levels | |||
:*[[HEV]] detected in stool during the initial period of recovery | |||
Revision as of 12:10, 26 August 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Varun Kumar, M.B.B.S. [2] João André Alves Silva, M.D. [3]
Overview
Laboratory Findings
Every patient with acute or chronic hepatitis, which cannot be explained by other causes, should be tested for hepatitis E.[1] Unfortunately, the different available assays show different specificity and sensitivity.[2]
Throughout the course of infection, serologic markers will vary according to the stage of the disease:[2]
- Incubation period
- Symptom onset
- IgM and IgG antibody detection
- Elevations on serum aminotransferase and symptom onset
- HEV detected in stool
- Recovery
The following tests are done to identify and monitor liver damage from hepatitis B:
- Albumin level
- Liver function tests
- Prothrombin time
- Antibody test
Since cases of hepatitis E are not clinically distinguishable from other types of acute viral hepatitis, diagnosis is made by blood tests which detect elevated antibody levels of specific antibodies to hepatitis E in the body or by reverse transcriptase polymerase chain reaction (RT-PCR). Unfortunately, such tests are not widely available.
Hepatitis E should be suspected in outbreaks of waterborne hepatitis occurring in developing countries, especially if the disease is more severe in pregnant women, or if hepatitis A has been excluded. If laboratory tests are not available, epidemiologic evidence can help in establishing a diagnosis.
References
- ↑ Wedemeyer H, Pischke S, Manns MP (2012). "Pathogenesis and treatment of hepatitis e virus infection". Gastroenterology. 142 (6): 1388–1397.e1. doi:10.1053/j.gastro.2012.02.014. PMID 22537448.
- ↑ 2.0 2.1 Hoofnagle JH, Nelson KE, Purcell RH (2012). "Hepatitis E." N Engl J Med. 367 (13): 1237–44. doi:10.1056/NEJMra1204512. PMID 23013075.