Langerhans cell histiocytosis physical examination

Langerhans cell histiocytosis Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Langerhans cell histiocytosis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Chest X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Langerhans cell histiocytosis physical examination On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Langerhans cell histiocytosis physical examination All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Langerhans cell histiocytosis physical examination
on Langerhans cell histiocytosis physical examination
Langerhans cell histiocytosis physical examination in the news
Blogs on Langerhans cell histiocytosis physical examination
Directions to Hospitals Treating Langerhans cell histiocytosis
Risk calculators and risk factors for Langerhans cell histiocytosis physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.

Physical Findings

Organs involved:

• Bone: Most frequent in both unifocal and disseminated disease presenting as painful swelling. Skull, long bone of upper extremity, flat bones are affected in descending order. Infiltration in hands and feet is unusual. Osteolytic lesions can lead to pathological fractures.
• Skin: Commonly present as rash which varies between scaly erythematous lesions to red papules pronounced in intertriginous areas. Up to 80% of LS would have extensive eruptions on the scalp.
• Bone marrow : Pancytopenia with super added infection usually implies poor prognosis. Anemia can be due to number of factors and not necessarily implies bone marrow infiltration.
• Lymph node: cervical commonest. enlargement of the liver in 20%, spleen in 30% and lymph nodes in 50% of HSC.
• Endocrine glands:Hypothalamic pituitary axis commonly involved. Diabetes insipidus most common. Anterior pituitary hormone deficiency is usually permanent.
• Lungs:
• Less frequently GIT, CNS.

Skin

Hand

• 
  Langerhans cell histiocytosis. Adapted from Dermatology Atlas.
• 
  Langerhans cell histiocytosis. Adapted from Dermatology Atlas.
• 
  Langerhans cell histiocytosis. Adapted from Dermatology Atlas.

References

Template:WikiDoc Sources