Enterovirus 68 future or investigational therapies: Difference between revisions
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===Antiviral Medication=== | ===Antiviral Medication=== | ||
* Pleconaril | * Pleconaril has shown benefit in patients with severe life-threatening enterovirus infections. This antiviral drug prevents the attachment of the virus to the host cell and integration of its RNA to the host DNA. <ref name="RotbartWebster2001">{{cite journal|last1=Rotbart|first1=H. A.|last2=Webster|first2=A. D.|title=Treatment of Potentially Life-Threatening Enterovirus Infections with Pleconaril|journal=Clinical Infectious Diseases|volume=32|issue=2|year=2001|pages=228–235|issn=1058-4838|doi=10.1086/318452}}</ref> | ||
* The table shown below describes the possible targets for antiviral treatment against enterovirus infections. | |||
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center | |||
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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Target}} | |||
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Antiviral Drugs}} | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Protease 2A or 3C | |||
| style="padding: 5px 5px; background: #F5F5F5;" |Rupintrivir, Br-UTP, AG7088 derivative | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |Capsid binders | |||
| style="padding: 5px 5px; background: #F5F5F5;" |Pleconaril, Pirodavirb, pyridazinyl oxime ethersb (BTA-39c), pyridyl imidazolidinonesc; NF-449c, V-073 | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |RNA replication | |||
| style="padding: 5px 5px; background: #F5F5F5;" |Enviroxime, TTP-8307, vinylacetylene analogs, GW5074c, Benzimidazoles, N(6)-benzyladenosine, metrifudil | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |RNA polymerase | |||
| style="padding: 5px 5px; background: #F5F5F5;" |2′C–Me-cytidine, 4′-azidocytidine, 2′C-ME-adenosine, ribavirin, DTriP-22c, aurintricarboxylic acid, gliotoxin, amiloride | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Proteins involved in replication & assembly | |||
| style="padding: 5px 5px; background: #F5F5F5;" |Brefeldin A, geldenamycin, 17AAG | |||
|- | |||
| style="padding: 5px 5px; background: #F5F5F5;"colspan="2"|<small> Adapted from "The enteroviruses: Problems in need of treatments"<ref name="Abzug2014">{{cite journal|last1=Abzug|first1=Mark J.|title=The enteroviruses: Problems in need of treatments|journal=Journal of Infection|volume=68|year=2014|pages=S108–S114|issn=01634453|doi=10.1016/j.jinf.2013.09.020}}</ref></small> | |||
|} | |||
==References== | ==References== | ||
Revision as of 18:17, 8 September 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]
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Overview
Future or Investigational Therapies
Immune globulin
- Studies in neonates with enterovirus infection suggest a possible benefit of the use of immune globulin in the treatment of this viral infection[1][2], however, more studies need to be done do confirm the benefit of this treatment.
- The development of IVIG with high levels of enterovirus antibody has shown benefit in in vitro and mouse models studies for enterovirus subtype 71, however, this has not been studied for subtype 68.[3]
Antiviral Medication
- Pleconaril has shown benefit in patients with severe life-threatening enterovirus infections. This antiviral drug prevents the attachment of the virus to the host cell and integration of its RNA to the host DNA. [4]
- The table shown below describes the possible targets for antiviral treatment against enterovirus infections.
| Target | Antiviral Drugs |
|---|---|
| Protease 2A or 3C | Rupintrivir, Br-UTP, AG7088 derivative |
| Capsid binders | Pleconaril, Pirodavirb, pyridazinyl oxime ethersb (BTA-39c), pyridyl imidazolidinonesc; NF-449c, V-073 |
| RNA replication | Enviroxime, TTP-8307, vinylacetylene analogs, GW5074c, Benzimidazoles, N(6)-benzyladenosine, metrifudil |
| RNA polymerase | 2′C–Me-cytidine, 4′-azidocytidine, 2′C-ME-adenosine, ribavirin, DTriP-22c, aurintricarboxylic acid, gliotoxin, amiloride |
| Proteins involved in replication & assembly | Brefeldin A, geldenamycin, 17AAG |
| Adapted from "The enteroviruses: Problems in need of treatments"[5] | |
References
- ↑ Marc Tebruegge & Nigel Curtis (2009). "Enterovirus infections in neonates". Seminars in fetal & neonatal medicine. 14 (4): 222–227. doi:10.1016/j.siny.2009.02.002. PMID 19303380. Unknown parameter
|month=ignored (help) - ↑ M. J. Abzug, H. L. Keyserling, M. L. Lee, M. J. Levin & H. A. Rotbart (1995). "Neonatal enterovirus infection: virology, serology, and effects of intravenous immune globulin". Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 20 (5): 1201–1206. PMID 7620000. Unknown parameter
|month=ignored (help) - ↑ Rui-Yuan Cao, Jian-Feng Han, Tao Jiang, Xue Tian, Man Yu, Yong-Qiang Deng, E.-De Qin & Cheng-Feng Qin (2011). "In vitro and in vivo characterization of a new enterovirus type 71-specific human intravenous immunoglobulin manufactured from selected plasma donors". Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 51 (4): 246–249. doi:10.1016/j.jcv.2011.05.002. PMID 21641277. Unknown parameter
|month=ignored (help) - ↑ Rotbart, H. A.; Webster, A. D. (2001). "Treatment of Potentially Life-Threatening Enterovirus Infections with Pleconaril". Clinical Infectious Diseases. 32 (2): 228–235. doi:10.1086/318452. ISSN 1058-4838.
- ↑ Abzug, Mark J. (2014). "The enteroviruses: Problems in need of treatments". Journal of Infection. 68: S108–S114. doi:10.1016/j.jinf.2013.09.020. ISSN 0163-4453.