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	Polymorphous light eruption;
ICD-10	L56.4
ICD-9	692.72
DiseasesDB	10327
eMedicine	derm/342

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Revision as of 12:16, 26 September 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Overview

Polymorphous light eruption (PLE), or polymorphic light eruption, is a skin complaint caused by sunlight. Symptoms include skin irritations, which may be itchy or painful, and are sometimes confused with hives. These irritations appear upon exposure to sunlight—sometimes as little as 15 minutes of exposure to the sun can bring onset of the condition—and may last from 1 to 7 days. Generally, PLE resolves without treatment; also, PLE irritations generally leave no scar. The cases of this condition are most common between the spring and autumn months in the northern hemisphere.

Typically, 10-20% of the population are affected. It is more common in females than in males. The condition can affect all ethnic groups and research suggests that 20% of patients have a family history of the complaint. Those suffering from PMLE usually do so by age 30.

The cause of PLE is not yet understood. It is thought to be due to a type IV delayed-type hypersensitivity reaction.

Diagnosis

Physical Examination

Skin

Trunk

Polymorphic light eruption. Adapted from Dermatology Atlas.^[1]
Polymorphic light eruption. Adapted from Dermatology Atlas.^[1]
Polymorphic light eruption. Adapted from Dermatology Atlas.^[1]
Polymorphic light eruption. Adapted from Dermatology Atlas.^[1]
Polymorphic light eruption. Adapted from Dermatology Atlas.^[1]
Polymorphic light eruption. Adapted from Dermatology Atlas.^[1]
Polymorphic light eruption. Adapted from Dermatology Atlas.^[1]

Ear

Polymorphic light eruption. Adapted from Dermatology Atlas.^[1]
Polymorphic light eruption. Adapted from Dermatology Atlas.^[1]

Experimental treatments

As of 2008 a company in Australia named Clinuvel Pharmaceuticals Limited is performing clinical trials with a melanocyte-stimulating hormone named melanotan (which they refer to as CUV1647) for polymorphous light eruption.^[2]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 "Dermatology Atlas".
↑ http://www.clinuvel.com/en/faqs/

External links

Template:SIB

Template:WikiDoc Sources

[Dermatology_Atlas-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 "Dermatology Atlas".

[Clinuvel-2] ttp://www.clinuvel.com/en/faqs/

[1]

[2]

@@ Line 27: / Line 27: @@
 ===Physical Examination===
 ====Skin====
+=====Trunk=====
 <gallery>
 Image:Polymorphic light eruption01.jpg|Polymorphic light eruption. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/  Adapted from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>
@@ Line 41: / Line 42: @@
 Image:Polymorphic light eruption06.jpg|Polymorphic light eruption. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/  Adapted from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>
 Image:Polymorphic light eruption07.jpg|Polymorphic light eruption. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/  Adapted from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>
+</gallery>
+=====Ear=====
+<gallery>
 Image:Polymorphic light eruption08.jpg|Polymorphic light eruption. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/  Adapted from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>
 Image:Polymorphic light eruption09.jpg|Polymorphic light eruption. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/  Adapted from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>
 </gallery>

v t e Diseases of the skin and subcutaneous tissue (integumentary system) (L, 680-709)
Infections	Template:Navbox subgroup
Bullous disorders	acantholysis (Pemphigus, Transient acantholytic dermatosis) · Pemphigoid (Bullous, Cicatricial, Gestational) · Dermatitis herpetiformis
Inflammatory	Template:Navbox subgroup
Radiation-related disorders	Sunburn · actinic rays (Actinic keratosis, Actinic cheilitis) · Polymorphous light eruption (Acne aestivalis) · Radiodermatitis · Erythema ab igne
Pigmentation disorder	hypopigmentation (Albinism, Vitiligo) · hyperpigmentation (Melasma, Freckle, Café au lait spot, Lentigo/Liver spot, Acanthosis nigricans, Acral acanthotic anomaly)
Other skin	keratosis/hyperkeratosis (Seborrheic keratosis, Callus) · other epidermal thickening (Ichthyosis acquisita, Palmoplantar keratoderma) skin ulcer (Pyoderma gangrenosum, Bedsore) Cutaneous Markers of Internal Malignancy (Florid cutaneous papillomatosis, acanthosis nigricans, sign of Leser-Trelat) atrophic (Lichen sclerosus, Acrodermatitis chronica atrophicans) necrobiosis (Granuloma annulare, Necrobiosis lipoidica) · other granuloma (Granuloma faciale, Pyogenic granuloma) cutaneous vasculitis (Livedoid vasculitis, Erythema elevatum diutinum)
Connective tissues	collagen disease: Keloid localized connective tissue disorders: Lupus erythematosus (Discoid lupus erythematosus, Subacute cutaneous lupus erythematosus) · Scleroderma/Morphea · Linear scleroderma · Calcinosis cutis · Sclerodactyly · Ainhum
see also congenital, neoplasia

Polymorphous light eruption
ICD-10	L56.4
ICD-9	692.72
DiseasesDB	10327
eMedicine	derm/342