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==Overview==
==Overview==
From the early 1950s onward, Fredrickson specialized in the study of plasma lipoproteins, compounds of proteins and lipids which transport lipids in the blood. However, the study of lipids in the blood has started early in the 1900's. In 1949, Faraday Society in Birmingham organized the first symposium on lipoproteins and separated for the first time lipoproteins into alpha and beta types.  In 1950, LDL was first isolated.<ref name="dx.doi.org">{{Cite web | last = | first = | title = http://dx.doi.org/10.1021/ja01157a121 | url = http://dx.doi.org/10.1021/ja01157a121 | publisher = | date = | accessdate = 8 November 2013 }}</ref>  In 1973, Myant first hypothesized the role of LDL in the metabolism of [[cholesterol]].<ref name="pmid4354844">{{cite journal| author=Myant NB| title=Cholesterol metabolism. | journal=J Clin Pathol Suppl (Assoc Clin Pathol) | year= 1973 | volume= 5 | issue=  | pages= 1-4 | pmid=4354844 | doi= | pmc=PMC1436101 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4354844  }} </ref>
From the early 1950s onward, Fredrickson specialized in the study of plasma [[lipoprotein]]s, compounds of [[protein]]s and [[lipid]]s which transport lipids in the blood. However, the study of [[lipid]]s in the blood has started early in the 1900's. In 1949, Faraday Society in Birmingham organized the first symposium on [[lipoprotein]]s and separated for the first time lipoproteins into alpha and beta types.  In 1950, LDL was first isolated.<ref name="dx.doi.org">{{Cite web | last = | first = | title = http://dx.doi.org/10.1021/ja01157a121 | url = http://dx.doi.org/10.1021/ja01157a121 | publisher = | date = | accessdate = 8 November 2013 }}</ref>  In 1973, Myant first hypothesized the role of LDL in the metabolism of [[cholesterol]].<ref name="pmid4354844">{{cite journal| author=Myant NB| title=Cholesterol metabolism. | journal=J Clin Pathol Suppl (Assoc Clin Pathol) | year= 1973 | volume= 5 | issue=  | pages= 1-4 | pmid=4354844 | doi= | pmc=PMC1436101 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4354844  }} </ref>


==Historical Perspective==
==Historical Perspective==
* In 1949, a new method for quantitative measurement of LDL and other lipoproteins using ultracentrifuge was developed.<ref name="GOFMAN-1949">{{Cite journal | last1 = GOFMAN | first1 = JW. | last2 = LINDGREN | first2 = FT. | last3 = ELLIOTT | first3 = H. | title = Ultracentrifugal studies of lipoproteins of human serum. | journal = J Biol Chem | volume = 179 | issue = 2 | pages = 973-9 | month = Jun | year = 1949 | doi = | PMID = 18150027 }}</ref>
* In 1949, a new method for quantitative measurement of LDL and other [[lipoprotein]]s using ultracentrifuge was developed.<ref name="GOFMAN-1949">{{Cite journal | last1 = GOFMAN | first1 = JW. | last2 = LINDGREN | first2 = FT. | last3 = ELLIOTT | first3 = H. | title = Ultracentrifugal studies of lipoproteins of human serum. | journal = J Biol Chem | volume = 179 | issue = 2 | pages = 973-9 | month = Jun | year = 1949 | doi = | PMID = 18150027 }}</ref>


* In 1950, LDL was first isolated.<ref name="dx.doi.org">{{Cite web | last = | first = | title = http://dx.doi.org/10.1021/ja01157a121 | url = http://dx.doi.org/10.1021/ja01157a121 | publisher = | date = | accessdate = 8 November 2013 }}</ref>
* In 1950, LDL was first isolated.<ref name="dx.doi.org">{{Cite web | last = | first = | title = http://dx.doi.org/10.1021/ja01157a121 | url = http://dx.doi.org/10.1021/ja01157a121 | publisher = | date = | accessdate = 8 November 2013 }}</ref>


* In 1963, another lipoprotein, Lp(a), was discovered as a complex particle in human plasma in an immunochemical study.<ref name="BERG-1963">{{Cite journal | last1 = BERG | first1 = K. | title = A NEW SERUM TYPE SYSTEM IN MAN--THE LP SYSTEM. | journal = Acta Pathol Microbiol Scand | volume = 59 | issue = | pages = 369-82 | month = | year = 1963 | doi = | PMID = 14064818 }}</ref>
* In 1963, another [[lipoprotein]], Lp(a), was discovered as a complex particle in human plasma in an immunochemical study.<ref name="BERG-1963">{{Cite journal | last1 = BERG | first1 = K. | title = A NEW SERUM TYPE SYSTEM IN MAN--THE LP SYSTEM. | journal = Acta Pathol Microbiol Scand | volume = 59 | issue = | pages = 369-82 | month = | year = 1963 | doi = | PMID = 14064818 }}</ref>


* In 1973, Myant first hypothesized the role of LDL in the metabolism of [[cholesterol]].<ref name="pmid4354844">{{cite journal| author=Myant NB| title=Cholesterol metabolism. | journal=J Clin Pathol Suppl (Assoc Clin Pathol) | year= 1973 | volume= 5 | issue=  | pages= 1-4 | pmid=4354844 | doi= | pmc=PMC1436101 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4354844  }} </ref>
* In 1973, Myant first hypothesized the role of LDL in the metabolism of [[cholesterol]].<ref name="pmid4354844">{{cite journal| author=Myant NB| title=Cholesterol metabolism. | journal=J Clin Pathol Suppl (Assoc Clin Pathol) | year= 1973 | volume= 5 | issue=  | pages= 1-4 | pmid=4354844 | doi= | pmc=PMC1436101 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4354844  }} </ref>

Revision as of 22:53, 28 September 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Rim Halaby, M.D. [3]

Overview

From the early 1950s onward, Fredrickson specialized in the study of plasma lipoproteins, compounds of proteins and lipids which transport lipids in the blood. However, the study of lipids in the blood has started early in the 1900's. In 1949, Faraday Society in Birmingham organized the first symposium on lipoproteins and separated for the first time lipoproteins into alpha and beta types. In 1950, LDL was first isolated.[1] In 1973, Myant first hypothesized the role of LDL in the metabolism of cholesterol.[2]

Historical Perspective

  • In 1949, a new method for quantitative measurement of LDL and other lipoproteins using ultracentrifuge was developed.[3]
  • In 1950, LDL was first isolated.[1]
  • In 1963, another lipoprotein, Lp(a), was discovered as a complex particle in human plasma in an immunochemical study.[4]
  • In 1973, Myant first hypothesized the role of LDL in the metabolism of cholesterol.[2]
  • In 1979, the Lipid Research Clinics Coronary Primary Prevention Trial (LRC-CPPT) demonstrated that reductions in total cholesterol and LDL were associated with reduction in CHD risk. It was reported that a 25% reduction in cholesterol or a 35% reduction in LDL cholesterol resulted in a 49% decrease in CHD risk.[5][6]

References

  1. ↑ 1.0 1.1 "http://dx.doi.org/10.1021/ja01157a121". Retrieved 8 November 2013. External link in |title= (help)
  2. ↑ 2.0 2.1 Myant NB (1973). "Cholesterol metabolism". J Clin Pathol Suppl (Assoc Clin Pathol). 5: 1–4. PMC 1436101. PMID 4354844.
  3. ↑ GOFMAN, JW.; LINDGREN, FT.; ELLIOTT, H. (1949). "Ultracentrifugal studies of lipoproteins of human serum". J Biol Chem. 179 (2): 973–9. PMID 18150027. Unknown parameter |month= ignored (help)
  4. ↑ BERG, K. (1963). "A NEW SERUM TYPE SYSTEM IN MAN--THE LP SYSTEM". Acta Pathol Microbiol Scand. 59: 369–82. PMID 14064818.
  5. ↑ "Plasma lipid distributions in selected North American populations: the Lipid Research Clinics Program Prevalence Study. The Lipid Research Clinics Program Epidemiology Committee". Circulation. 60 (2): 427–39. 1979. PMID 312704. Unknown parameter |month= ignored (help)
  6. ↑ "The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease". JAMA. 251 (3): 351–64. 1984. PMID 6361299. Unknown parameter |month= ignored (help)



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